HIPHOP chemogenomics database

YNL081C / SWS2

Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL081C / SWS2

Click on Significant Values for Screen Details

Top fitness defect scores for YNL081C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_310	1273-0058	22.10	1.1 µM	6.73E-75	mitochondrial stress	1	7.91E-109
2	SGTC_275	trichlorophene	13.20	5.7 µM	4.13E-28	mitochondrial stress	15	2.44E-40
3	SGTC_236	1509-0011	11.80	5.3 µM	7.35E-23		154	1.16E-32
4	SGTC_173	1273-0061	11.30	2.7 µM	6.51E-21	mitochondrial stress	31	8.18E-30
5	SGTC_2016	5121758	11.00	140.0 µM	7.06E-20	redox potentiating	2	2.66E-28
6	SGTC_2022	5136654	8.74	200.0 µM	2.80E-13		3	1.16E-18
7	SGTC_2250	alverine citrate	8.23	130.0 µM	5.78E-12		17	9.54E-17
8	SGTC_70	0141-0289	8.05	43.3 µM	1.57E-11	mitochondrial stress	40	4.10E-16
9	SGTC_63	0099-0242	7.93	26.7 µM	3.04E-11	mitochondrial stress	11	1.07E-15
10	SGTC_2232	chlorophetanol	7.11	41.5 µM	2.33E-9	TRP & mitochondrial translation	26	5.97E-13
11	SGTC_10	0279-0212	6.67	42.6 µM	1.91E-8	TRP & mitochondrial translation	20	1.28E-11
12	SGTC_1623	st003709	6.08	20.3 µM	2.72E-7	calcium & mitochondrial duress	13	6.05E-10
13	SGTC_1155	4088-0394	5.70	48.2 µM	1.33E-6		2	6.07E-9
14	SGTC_2570	licareol	5.65	100.0 µM	1.60E-6		6	7.93E-9
15	SGTC_1742	st038235	5.55	28.9 µM	2.39E-6	mitochondrial stress	59	1.41E-8
16	SGTC_2020	4017018	5.38	200.0 µM	4.68E-6		3	3.76E-8
17	SGTC_2023	5144124	5.31	124.0 µM	6.15E-6		4	5.57E-8
18	SGTC_314	1671-0008	5.21	2.7 µM	8.99E-6		17	9.66E-8
19	SGTC_2533	agelasine	5.17	13.7 µM	1.04E-5	ERG2	19	1.19E-7
20	SGTC_2526	patulin	5.12	37.6 µM	1.24E-5		45	1.54E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.512	8.01E-224	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.496	1.13E-207	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.479	2.39E-192	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.472	4.32E-185	YLR260W	LCB5	hom	Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.467	9.88E-182	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.462	1.21E-176	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.453	3.30E-169	YGR165W	MRPS35	hom	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.452	8.98E-169	YNL005C	MRP7	hom	Mitochondrial ribosomal protein of the large subunit
0.448	3.23E-165	YMR072W	ABF2	hom	Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.446	1.69E-163	YPL183W-A	RTC6	hom	Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.433	2.11E-153	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.432	1.83E-152	YPR100W	MRPL51	hom	Mitochondrial ribosomal protein of the large subunit
0.429	4.94E-150	YLR069C	MEF1	hom	Mitochondrial elongation factor involved in translational elongation
0.427	9.38E-149	YKL138C	MRPL31	hom	Mitochondrial ribosomal protein of the large subunit
0.427	2.58E-148	YMR098C	ATP25	hom	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene