HIPHOP chemogenomics database

YNL083W / SAL1

ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL083W / SAL1

Click on Significant Values for Screen Details

Top fitness defect scores for YNL083W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_86	0417-1630	5.13	471.9 µM	7.45E-8	ubiquinone biosynthesis & proteasome	110	1.46E-7
2	SGTC_2799	7812892	4.73	81.8 µM	6.16E-7	superoxide	19	1.11E-6
3	SGTC_1895	st058434	4.40	18.3 µM	3.18E-6		12	5.32E-6
4	SGTC_1957	st077035	4.32	62.4 µM	4.71E-6		10	7.76E-6
5	SGTC_686	1319-0111	4.31	510.0 µM	4.87E-6	60S ribosome export	21	8.02E-6
6	SGTC_493	zm226600	4.24	134.0 µM	7.02E-6	mitochondrial processes	12	1.14E-5
7	SGTC_3331	9141060	4.19	2.0 µM	8.69E-6	cell wall	28	1.40E-5
8	SGTC_1891	st059073	4.19	26.2 µM	8.82E-6	TSC3-RPN4	18	1.42E-5
9	SGTC_781	4335-2806	4.14	94.4 µM	1.07E-5		14	1.70E-5
10	SGTC_142	0335-0849	4.01	62.7 µM	1.93E-5	ubiquinone biosynthesis & proteasome	123	3.00E-5
11	SGTC_158	k038-0087	4.00	26.4 µM	2.08E-5	ubiquinone biosynthesis & proteasome	133	3.22E-5
12	SGTC_1956	st077085	3.80	54.0 µM	4.77E-5		22	7.14E-5
13	SGTC_600	1495-0418	3.75	41.6 µM	6.01E-5	RPP1 & pyrimidine depletion	15	8.90E-5
14	SGTC_1454	4239-0054	3.73	42.6 µM	6.59E-5		42	9.73E-5
15	SGTC_2596	sinensetin	3.60	100.0 µM	1.10E-4		45	1.59E-4
16	SGTC_479	n-linoleoylglycine	3.48	10.0 µM	1.78E-4		19	2.52E-4
17	SGTC_1329	1447-1697	3.43	50.6 µM	2.11E-4		28	2.97E-4
18	SGTC_3320	9137005	3.28	35.1 µM	3.85E-4	endomembrane recycling	32	5.27E-4
19	SGTC_2615	purpurogallin-4-carboxylic acid	3.20	100.0 µM	5.12E-4	redox potentiating	104	6.93E-4
20	SGTC_2962	9082311	3.18	13.2 µM	5.53E-4		55	7.46E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.198	5.39E-31	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.182	1.93E-26	YPR064W_d	YPR064W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.178	2.88E-25	YNR041C	COQ2	hom	Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.173	4.80E-24	YML034C-A_d	YML034C-A_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.169	8.33E-23	YLR201C	COQ9	hom	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.168	1.65E-22	YOL008W	COQ10	hom	Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q₆ to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
0.167	2.31E-22	YLR202C_d	YLR202C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron
0.167	2.72E-22	YGL119W	COQ8	hom	Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.158	4.31E-20	YLR292C	SEC72	hom	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.155	1.57E-19	YCL014W	BUD3	hom	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.154	3.62E-19	YDR204W	COQ4	hom	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.150	2.35E-18	YML110C	COQ5	hom	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.148	5.59E-18	YNR042W_d	YNR042W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.147	1.20E-17	YPR065W	ROX1	hom	Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.144	5.29E-17	YGR255C	COQ6	hom	Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)