YNL086W_p / SNN1

Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL086W / SNN1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:6.21|P-value:2.62E-12 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.61|P-value:2.94E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:2.96|P-value:5.05E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.50|P-value:5.12E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:2.90|P-value:6.42E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.23|P-value:1.59E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.87|P-value:3.02E-8 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-2.96|P-value:4.88E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.00|P-value:4.23E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.34|P-value:9.79E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:2.91|P-value:6.18E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:6.41|P-value:5.03E-13 ID:SGTC_566|Compound:0958-0068|FD-Score:3.27|P-value:1.43E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:2.79|P-value:9.71E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.40|P-value:7.49E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.32|P-value:1.13E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:2.96|P-value:5.11E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-4.08|P-value:2.75E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.77|P-value:1.38E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:5.42|P-value:8.60E-10 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.29|P-value:1.29E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:2.79|P-value:9.69E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.39|P-value:5.46E-7 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.24|P-value:1.51E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-2.84|P-value:7.76E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.00|P-value:4.13E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.34|P-value:1.03E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.65|P-value:1.17E-7 ID:SGTC_1800|Compound:st050079|FD-Score:2.85|P-value:7.69E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-2.98|P-value:4.56E-4 ID:SGTC_1898|Compound:st060199|FD-Score:2.96|P-value:5.12E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.63|P-value:1.33E-7 ID:SGTC_2168|Compound:5727979|FD-Score:-2.96|P-value:4.78E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-3.42|P-value:6.88E-5 ID:SGTC_2237|Compound:6667747|FD-Score:2.79|P-value:9.54E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.18|P-value:2.01E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:2.79|P-value:9.62E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-2.85|P-value:7.51E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.51|P-value:4.78E-5 ID:SGTC_2412|Compound:st077135|FD-Score:2.98|P-value:4.74E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.83|P-value:1.05E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.06|P-value:3.43E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.32|P-value:1.06E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-4.35|P-value:6.47E-7 ID:SGTC_3207|Compound:9114163|FD-Score:2.95|P-value:5.22E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.19|P-value:1.94E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:6.21|P-value:2.62E-12 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.61|P-value:2.94E-5 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:2.96|P-value:5.05E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.50|P-value:5.12E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:2.90|P-value:6.42E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:-3.23|P-value:1.59E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:4.87|P-value:3.02E-8 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-2.96|P-value:4.88E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.00|P-value:4.23E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:-3.34|P-value:9.79E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:2.91|P-value:6.18E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:6.41|P-value:5.03E-13 ID:SGTC_566|Compound:0958-0068|FD-Score:3.27|P-value:1.43E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:2.79|P-value:9.71E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:-3.40|P-value:7.49E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:3.32|P-value:1.13E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:2.96|P-value:5.11E-4 ID:SGTC_984|Compound:1492-0255|FD-Score:-4.08|P-value:2.75E-6 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.77|P-value:1.38E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:5.42|P-value:8.60E-10 ID:SGTC_1235|Compound:benzylparaben|FD-Score:3.29|P-value:1.29E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:2.79|P-value:9.69E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.39|P-value:5.46E-7 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.24|P-value:1.51E-4 ID:SGTC_1603|Compound:st002045|FD-Score:-2.84|P-value:7.76E-4 ID:SGTC_1604|Compound:st002052|FD-Score:-3.00|P-value:4.13E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.34|P-value:1.03E-4 ID:SGTC_1712|Compound:st032288|FD-Score:4.65|P-value:1.17E-7 ID:SGTC_1800|Compound:st050079|FD-Score:2.85|P-value:7.69E-4 ID:SGTC_1819|Compound:st053448|FD-Score:-2.98|P-value:4.56E-4 ID:SGTC_1898|Compound:st060199|FD-Score:2.96|P-value:5.12E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.63|P-value:1.33E-7 ID:SGTC_2168|Compound:5727979|FD-Score:-2.96|P-value:4.78E-4 ID:SGTC_2173|Compound:5763948|FD-Score:-3.42|P-value:6.88E-5 ID:SGTC_2237|Compound:6667747|FD-Score:2.79|P-value:9.54E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-3.18|P-value:2.01E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:2.79|P-value:9.62E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-2.85|P-value:7.51E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.51|P-value:4.78E-5 ID:SGTC_2412|Compound:st077135|FD-Score:2.98|P-value:4.74E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.83|P-value:1.05E-5 ID:SGTC_2896|Compound:9052656|FD-Score:3.06|P-value:3.43E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.32|P-value:1.06E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-4.35|P-value:6.47E-7 ID:SGTC_3207|Compound:9114163|FD-Score:2.95|P-value:5.22E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.19|P-value:1.94E-4

Top fitness defect scores for YNL086W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_558 k064-0027 6.41 21.3 µM 5.03E-13 DNA damage response 6 7.13E-11
2 SGTC_65 0798-0905 6.21 35.0 µM 2.62E-12 calcium & mitochondrial duress 28 2.73E-10
3 SGTC_1194 1488-0194 5.42 225.0 µM 8.60E-10 11 3.02E-8
4 SGTC_373 0844-0104 4.87 25.9 µM 3.02E-8 ERAD & cell cycle 30 5.46E-7
5 SGTC_1712 st032288 4.65 53.4 µM 1.17E-7 calcium & mitochondrial duress 134 1.65E-6
6 SGTC_2021 4019055 4.63 173.0 µM 1.33E-7 endomembrane recycling 81 1.83E-6
7 SGTC_1495 4469-0029 4.39 237.0 µM 5.46E-7 90 5.77E-6
8 SGTC_2688 kanamycin b 3.83 96.7 µM 1.05E-5 calcium & mitochondrial duress 393 6.45E-5
9 SGTC_1132 3456-3614 3.77 2.5 µM 1.38E-5 tubulin folding & SWR complex 61 8.04E-5
10 SGTC_2390 9097792 3.51 176.6 µM 4.78E-5 27 2.23E-4
11 SGTC_308 4092-1169 3.50 104.0 µM 5.12E-5 plasma membrane duress 66 2.36E-4
12 SGTC_1673 st016611 3.34 27.3 µM 1.03E-4 72 4.17E-4
13 SGTC_649 1123-0311 3.32 367.0 µM 1.13E-4 endomembrane recycling 109 4.50E-4
14 SGTC_1235 benzylparaben 3.29 21.5 µM 1.29E-4 27 5.02E-4
15 SGTC_566 0958-0068 3.27 16.5 µM 1.43E-4 RSC & ERG11 35 5.46E-4
16 SGTC_3313 9133968 3.19 57.0 µM 1.94E-4 23 7.02E-4
17 SGTC_2896 9052656 3.06 71.4 µM 3.43E-4 endomembrane recycling 200 0.00112
18 SGTC_2412 st077135 2.98 33.4 µM 4.74E-4 73 0.00146
19 SGTC_265 mycophenolic acid 2.96 32.9 µM 5.05E-4 RPP1 & pyrimidine depletion 69 0.00154
20 SGTC_881 0833-0569 2.96 170.0 µM 5.11E-4 79 0.00155

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 2.70E-45 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.231 7.44E-42 YLR408C_p BLS1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
0.221 1.91E-38 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.212 1.62E-35 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.190 1.15E-28 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.182 2.10E-26 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.179 1.33E-25 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.179 1.89E-25 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.172 1.49E-23 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.166 3.51E-22 YOL016C CMK2 hom Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication
0.166 3.90E-22 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.165 6.50E-22 YHL002W HSE1 hom Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
0.163 3.03E-21 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.161 5.06E-21 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.157 7.33E-20 YCL021W-A_p YCL021W-A_p hom Putative protein of unknown function