YNL094W / APP1

Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL094W / APP1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.24|P-value:7.44E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.19|P-value:8.85E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:4.20|P-value:1.75E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.98|P-value:4.34E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.67|P-value:1.55E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.32|P-value:5.61E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.69|P-value:1.40E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.59|P-value:2.09E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:5.51|P-value:2.47E-8 ID:SGTC_815|Compound:1582-0027|FD-Score:3.90|P-value:6.11E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.37|P-value:4.67E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.07|P-value:3.05E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:3.90|P-value:6.07E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.78|P-value:5.42E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.30|P-value:5.97E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.41|P-value:4.06E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:5.45|P-value:3.45E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.82|P-value:4.48E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:5.76|P-value:5.67E-9 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.70|P-value:1.35E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.53|P-value:2.61E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.36|P-value:4.85E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.32|P-value:5.66E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.49|P-value:3.02E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.39|P-value:4.40E-4 ID:SGTC_1916|Compound:st067606|FD-Score:4.85|P-value:8.22E-7 ID:SGTC_1954|Compound:st077032|FD-Score:-3.16|P-value:5.83E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.31|P-value:5.84E-4 ID:SGTC_2058|Compound:5236698|FD-Score:4.53|P-value:3.96E-6 ID:SGTC_2167|Compound:5876490|FD-Score:-3.68|P-value:8.27E-5 ID:SGTC_2244|Compound:6635614|FD-Score:4.20|P-value:1.72E-5 ID:SGTC_2300|Compound:7976697|FD-Score:3.25|P-value:7.10E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.00|P-value:9.96E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.42|P-value:6.43E-6 ID:SGTC_2468|Compound:5987765|FD-Score:3.59|P-value:2.09E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.39|P-value:4.44E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-5.88|P-value:1.09E-9 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.17|P-value:1.01E-5 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.46|P-value:3.45E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.19|P-value:8.75E-4 ID:SGTC_2746|Compound:daunorubicin|FD-Score:-3.04|P-value:8.87E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.46|P-value:3.43E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.61|P-value:1.94E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.09|P-value:7.40E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.19|P-value:5.15E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.90|P-value:6.27E-7 ID:SGTC_2981|Compound:9013952|FD-Score:-4.42|P-value:3.16E-6 ID:SGTC_2983|Compound:9022671|FD-Score:-3.19|P-value:5.26E-4 ID:SGTC_3017|Compound:9080681|FD-Score:4.62|P-value:2.56E-6 ID:SGTC_3204|Compound:9114183|FD-Score:-9.94|P-value:4.35E-24 ID:SGTC_3209|Compound:9113616|FD-Score:-4.06|P-value:1.62E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.67|P-value:1.53E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.80|P-value:1.05E-6 ID:SGTC_3263|Compound:9137018|FD-Score:5.14|P-value:1.86E-7 ID:SGTC_3265|Compound:9137266|FD-Score:3.84|P-value:7.92E-5 ID:SGTC_3268|Compound:9137683|FD-Score:4.02|P-value:3.78E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-3.49|P-value:1.71E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.24|P-value:7.44E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.19|P-value:8.85E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:4.20|P-value:1.75E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:3.98|P-value:4.34E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.67|P-value:1.55E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.32|P-value:5.61E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.69|P-value:1.40E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.59|P-value:2.09E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:5.51|P-value:2.47E-8 ID:SGTC_815|Compound:1582-0027|FD-Score:3.90|P-value:6.11E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.37|P-value:4.67E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.07|P-value:3.05E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:3.90|P-value:6.07E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.78|P-value:5.42E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.30|P-value:5.97E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.41|P-value:4.06E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:5.45|P-value:3.45E-8 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.82|P-value:4.48E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:5.76|P-value:5.67E-9 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.70|P-value:1.35E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.53|P-value:2.61E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.36|P-value:4.85E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.32|P-value:5.66E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.49|P-value:3.02E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.39|P-value:4.40E-4 ID:SGTC_1916|Compound:st067606|FD-Score:4.85|P-value:8.22E-7 ID:SGTC_1954|Compound:st077032|FD-Score:-3.16|P-value:5.83E-4 ID:SGTC_1986|Compound:st071812|FD-Score:3.31|P-value:5.84E-4 ID:SGTC_2058|Compound:5236698|FD-Score:4.53|P-value:3.96E-6 ID:SGTC_2167|Compound:5876490|FD-Score:-3.68|P-value:8.27E-5 ID:SGTC_2244|Compound:6635614|FD-Score:4.20|P-value:1.72E-5 ID:SGTC_2300|Compound:7976697|FD-Score:3.25|P-value:7.10E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.00|P-value:9.96E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.42|P-value:6.43E-6 ID:SGTC_2468|Compound:5987765|FD-Score:3.59|P-value:2.09E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.39|P-value:4.44E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-5.88|P-value:1.09E-9 ID:SGTC_2533|Compound:agelasine|FD-Score:-4.17|P-value:1.01E-5 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.46|P-value:3.45E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:3.19|P-value:8.75E-4 ID:SGTC_2746|Compound:daunorubicin|FD-Score:-3.04|P-value:8.87E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.46|P-value:3.43E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.61|P-value:1.94E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.09|P-value:7.40E-4 ID:SGTC_2933|Compound:9026794|FD-Score:-3.19|P-value:5.15E-4 ID:SGTC_2938|Compound:9059746|FD-Score:4.90|P-value:6.27E-7 ID:SGTC_2981|Compound:9013952|FD-Score:-4.42|P-value:3.16E-6 ID:SGTC_2983|Compound:9022671|FD-Score:-3.19|P-value:5.26E-4 ID:SGTC_3017|Compound:9080681|FD-Score:4.62|P-value:2.56E-6 ID:SGTC_3204|Compound:9114183|FD-Score:-9.94|P-value:4.35E-24 ID:SGTC_3209|Compound:9113616|FD-Score:-4.06|P-value:1.62E-5 ID:SGTC_3212|Compound:9128307|FD-Score:3.67|P-value:1.53E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.80|P-value:1.05E-6 ID:SGTC_3263|Compound:9137018|FD-Score:5.14|P-value:1.86E-7 ID:SGTC_3265|Compound:9137266|FD-Score:3.84|P-value:7.92E-5 ID:SGTC_3268|Compound:9137683|FD-Score:4.02|P-value:3.78E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-3.49|P-value:1.71E-4

Top fitness defect scores for YNL094W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1150 3909-7983 5.76 10.9 µM 5.67E-9 3 4.15E-9
2 SGTC_814 3342-0569 5.51 96.0 µM 2.47E-8 5 1.82E-8
3 SGTC_1121 fusaric acid 5.45 630.5 nM 3.45E-8 14 2.55E-8
4 SGTC_3263 9137018 5.14 49.5 µM 1.86E-7 4 1.39E-7
5 SGTC_2938 9059746 4.90 27.3 µM 6.27E-7 fatty acid desaturase (OLE1) 22 4.72E-7
6 SGTC_1916 st067606 4.85 49.2 µM 8.22E-7 18 6.19E-7
7 SGTC_3217 9129673 4.80 49.5 µM 1.05E-6 13 7.95E-7
8 SGTC_3017 9080681 4.62 49.5 µM 2.56E-6 9 1.94E-6
9 SGTC_2058 5236698 4.53 133.0 µM 3.96E-6 16 3.01E-6
10 SGTC_2394 5221648 4.42 200.0 µM 6.43E-6 15 4.92E-6
11 SGTC_2244 6635614 4.20 200.0 µM 1.72E-5 3 1.33E-5
12 SGTC_307 1501-1223 4.20 22.3 µM 1.75E-5 9 1.35E-5
13 SGTC_934 2950-0684 4.07 338.0 µM 3.05E-5 19 2.37E-5
14 SGTC_3268 9137683 4.02 49.5 µM 3.78E-5 9 2.94E-5
15 SGTC_310 1273-0058 3.98 1.1 µM 4.34E-5 mitochondrial stress 245 3.38E-5
16 SGTC_957 1187-1561 3.90 14.1 µM 6.07E-5 20 4.73E-5
17 SGTC_815 1582-0027 3.90 36.9 µM 6.11E-5 29 4.77E-5
18 SGTC_3265 9137266 3.84 49.5 µM 7.92E-5 9 6.20E-5
19 SGTC_1204 4049-0315 3.70 18.3 µM 1.35E-4 40 1.06E-4
20 SGTC_659 k018-0002 3.69 107.0 µM 1.40E-4 23 1.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.168 1.55E-22 YDR181C SAS4 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p
0.130 4.07E-14 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.122 1.10E-12 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.122 1.42E-12 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.120 2.59E-12 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.116 1.43E-11 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.110 1.78E-10 YLR079W SIC1 hom Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
0.106 7.43E-10 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.104 1.31E-9 YML068W ITT1 hom Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
0.100 5.67E-9 YPL191C_p YPL191C_p hom Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.099 8.06E-9 YMR305C SCW10 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
0.097 1.93E-8 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.095 3.60E-8 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.093 6.07E-8 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.089 2.23E-7 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress