YNL096C / RPS7B

Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL096C / RPS7B

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-4.33|P-value:2.39E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:3.98|P-value:8.74E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.67|P-value:2.69E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.40|P-value:6.88E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.42|P-value:6.37E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-6.24|P-value:2.30E-9 ID:SGTC_679|Compound:0422-0091|FD-Score:3.43|P-value:6.15E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.96|P-value:9.44E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:3.43|P-value:6.19E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.35|P-value:8.02E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.29|P-value:9.66E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.45|P-value:6.00E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:4.70|P-value:4.69E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.41|P-value:1.61E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.35|P-value:7.98E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.36|P-value:7.84E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.54|P-value:4.27E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.74|P-value:2.26E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.52|P-value:4.52E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.92|P-value:1.17E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.20|P-value:3.73E-5 ID:SGTC_1633|Compound:st005664|FD-Score:5.71|P-value:3.84E-8 ID:SGTC_1781|Compound:st038725|FD-Score:4.12|P-value:5.24E-5 ID:SGTC_2116|Compound:5511452|FD-Score:4.85|P-value:2.50E-6 ID:SGTC_2204|Compound:7233102|FD-Score:3.28|P-value:9.95E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.46|P-value:5.58E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.34|P-value:8.25E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.19|P-value:3.89E-5 ID:SGTC_2395|Compound:5646831|FD-Score:5.32|P-value:2.73E-7 ID:SGTC_2429|Compound:5902844|FD-Score:4.07|P-value:6.37E-5 ID:SGTC_2430|Compound:5571206|FD-Score:-4.44|P-value:1.54E-5 ID:SGTC_2464|Compound:5717415|FD-Score:4.34|P-value:2.18E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.44|P-value:6.12E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.86|P-value:1.37E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.77|P-value:1.88E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.80|P-value:3.07E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.08|P-value:6.28E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.29|P-value:9.71E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.97|P-value:9.29E-5 ID:SGTC_2873|Compound:9040596|FD-Score:4.79|P-value:3.21E-6 ID:SGTC_3042|Compound:9091578|FD-Score:-4.72|P-value:4.60E-6 ID:SGTC_3204|Compound:9114183|FD-Score:-3.98|P-value:9.33E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.33|P-value:2.39E-5 ID:SGTC_174|Compound:3553-0389|FD-Score:3.98|P-value:8.74E-5 ID:SGTC_251|Compound:melphalan|FD-Score:3.67|P-value:2.69E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:3.40|P-value:6.88E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.42|P-value:6.37E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-6.24|P-value:2.30E-9 ID:SGTC_679|Compound:0422-0091|FD-Score:3.43|P-value:6.15E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.96|P-value:9.44E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:3.43|P-value:6.19E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.35|P-value:8.02E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.29|P-value:9.66E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:-3.45|P-value:6.00E-4 ID:SGTC_993|Compound:3909-8757|FD-Score:4.70|P-value:4.69E-6 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.41|P-value:1.61E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.35|P-value:7.98E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.36|P-value:7.84E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.54|P-value:4.27E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:-3.74|P-value:2.26E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.52|P-value:4.52E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:-3.92|P-value:1.17E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.20|P-value:3.73E-5 ID:SGTC_1633|Compound:st005664|FD-Score:5.71|P-value:3.84E-8 ID:SGTC_1781|Compound:st038725|FD-Score:4.12|P-value:5.24E-5 ID:SGTC_2116|Compound:5511452|FD-Score:4.85|P-value:2.50E-6 ID:SGTC_2204|Compound:7233102|FD-Score:3.28|P-value:9.95E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.46|P-value:5.58E-4 ID:SGTC_2293|Compound:7624732|FD-Score:3.34|P-value:8.25E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.19|P-value:3.89E-5 ID:SGTC_2395|Compound:5646831|FD-Score:5.32|P-value:2.73E-7 ID:SGTC_2429|Compound:5902844|FD-Score:4.07|P-value:6.37E-5 ID:SGTC_2430|Compound:5571206|FD-Score:-4.44|P-value:1.54E-5 ID:SGTC_2464|Compound:5717415|FD-Score:4.34|P-value:2.18E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:-3.44|P-value:6.12E-4 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.86|P-value:1.37E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.77|P-value:1.88E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.80|P-value:3.07E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.08|P-value:6.28E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.29|P-value:9.71E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.97|P-value:9.29E-5 ID:SGTC_2873|Compound:9040596|FD-Score:4.79|P-value:3.21E-6 ID:SGTC_3042|Compound:9091578|FD-Score:-4.72|P-value:4.60E-6 ID:SGTC_3204|Compound:9114183|FD-Score:-3.98|P-value:9.33E-5

Top fitness defect scores for YNL096C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1633 st005664 5.71 67.9 µM 3.84E-8 7 5.74E-9
2 SGTC_2395 5646831 5.32 180.2 µM 2.73E-7 10 5.22E-8
3 SGTC_2116 5511452 4.85 16.9 µM 2.50E-6 6 6.30E-7
4 SGTC_2578 7,8-dihydroxyflavone 4.80 64.4 µM 3.07E-6 18 7.92E-7
5 SGTC_2873 9040596 4.79 71.4 µM 3.21E-6 25 8.33E-7
6 SGTC_993 3909-8757 4.70 62.7 µM 4.69E-6 10 1.27E-6
7 SGTC_1051 3253-3903 4.41 78.0 µM 1.61E-5 15 5.09E-6
8 SGTC_2464 5717415 4.34 7.7 µM 2.18E-5 9 7.16E-6
9 SGTC_1625 st003711 4.20 30.1 µM 3.73E-5 calcium & mitochondrial duress 30 1.31E-5
10 SGTC_2302 7771753 4.19 200.0 µM 3.89E-5 37 1.37E-5
11 SGTC_1781 st038725 4.12 66.3 µM 5.24E-5 NEO1 94 1.92E-5
12 SGTC_2429 5902844 4.07 64.4 µM 6.37E-5 21 2.38E-5
13 SGTC_174 3553-0389 3.98 74.3 µM 8.74E-5 21 3.40E-5
14 SGTC_2688 kanamycin b 3.97 96.7 µM 9.29E-5 calcium & mitochondrial duress 363 3.64E-5
15 SGTC_708 3448-5400 3.96 146.0 µM 9.44E-5 42 3.70E-5
16 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 3.86 66.7 µM 1.37E-4 28 5.64E-5
17 SGTC_2572 astragaloside iv 3.77 100.0 µM 1.88E-4 32 8.02E-5
18 SGTC_251 melphalan 3.67 456.5 µM 2.69E-4 DNA damage response 37 1.20E-4
19 SGTC_1366 1683-0113 3.54 21.9 µM 4.27E-4 19 2.01E-4
20 SGTC_1408 3909-7976 3.52 48.8 µM 4.52E-4 Golgi 37 2.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.132 1.52E-14 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.132 1.58E-14 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.123 7.36E-13 YKR057W RPS21A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.107 6.12E-10 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.106 7.59E-10 YOR295W UAF30 hom Subunit of UAF (upstream activation factor); UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
0.105 9.05E-10 YCL058C FYV5 hom Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
0.104 1.40E-9 YMR230W RPS10B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication
0.101 4.08E-9 YDR156W RPA14 hom RNA polymerase I subunit A14
0.101 4.78E-9 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.099 7.95E-9 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.099 9.91E-9 YOR067C ALG8 hom Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p
0.097 1.59E-8 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.095 3.56E-8 YGL236C MTO1 hom Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
0.094 5.19E-8 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.093 5.89E-8 YPL239W YAR1 hom Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with free Rps3p in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock