HIPHOP chemogenomics database

YNL097C-B_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL097C-B / YNL097C-B

Click on Significant Values for Screen Details

Top fitness defect scores for YNL097C-B deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_359	0081-0058	5.65	15.9 µM	4.19E-10	60S ribosome export	11	8.23E-9
2	SGTC_1134	3477-0009	5.51	42.5 µM	1.04E-9		13	1.78E-8
3	SGTC_1131	3454-3128	4.77	32.3 µM	1.08E-7		18	9.43E-7
4	SGTC_3165	9101544	4.54	49.5 µM	3.91E-7		6	2.82E-6
5	SGTC_2078	5212016	4.28	200.0 µM	1.58E-6	60S ribosome export	10	9.27E-6
6	SGTC_757	1066-0008	3.96	322.0 µM	8.01E-6	Golgi	18	3.72E-5
7	SGTC_1006	4099-6547	3.89	255.0 µM	1.13E-5		22	5.01E-5
8	SGTC_3102	9121669	3.89	49.5 µM	1.16E-5		11	5.09E-5
9	SGTC_2704	st078022	3.87	71.1 µM	1.22E-5		14	5.34E-5
10	SGTC_1314	1222-0010	3.80	41.1 µM	1.74E-5		14	7.20E-5
11	SGTC_2768	sulfasalazine	3.71	50.2 µM	2.70E-5		23	1.05E-4
12	SGTC_835	0312-0010	3.56	67.2 µM	5.30E-5		20	1.87E-4
13	SGTC_2925	9010536	3.55	32.5 µM	5.51E-5	azole & statin	67	1.94E-4
14	SGTC_2762	leflunomide	3.53	42.1 µM	6.00E-5		47	2.08E-4
15	SGTC_753	1322-0200	3.49	289.0 µM	7.00E-5		35	2.37E-4
16	SGTC_741	4582-0002	3.45	126.0 µM	8.63E-5		25	2.84E-4
17	SGTC_1003	4049-0218	3.43	100.0 µM	9.45E-5		36	3.07E-4
18	SGTC_1929	genistein trimethyl ether	3.35	50.5 µM	1.30E-4		35	4.04E-4
19	SGTC_1127	asiatic acid	3.33	681.4 nM	1.43E-4		44	4.37E-4
20	SGTC_58	0957-0393	3.31	9.0 µM	1.52E-4	cell wall	451	4.60E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.212	1.64E-35	YMR041C	ARA2	hom	NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase
0.172	8.40E-24	YGR025W_d	YGR025W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.168	1.17E-22	YGL004C	RPN14	hom	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.164	1.53E-21	YML084W_d	YML084W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.161	6.61E-21	YMR034C_p	YMR034C_p	hom	Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.153	5.69E-19	YJL068C	YJL068C	hom	Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.151	1.53E-18	YGR008C	STF2	hom	Protein involved in resistance to dessication stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to the F0 sector of mitochondrial F1F0 ATPase in vitro and is proposed to modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress
0.151	1.68E-18	YER060W-A	FCY22	hom	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.149	3.84E-18	YOR283W	YOR283W	hom	Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene
0.147	1.18E-17	YHR035W_p	YHR035W_p	hom	Putative protein of unknown function; not an essential gene
0.145	3.82E-17	YGL181W	GTS1	hom	Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations
0.143	7.07E-17	YLR414C	PUN1	hom	Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.143	8.17E-17	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.142	1.45E-16	YBR085W	AAC3	hom	Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.139	5.59E-16	YJL211C_d	YJL211C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2