YNL106C / INP52

Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL106C / INP52

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:-3.79|P-value:3.20E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:2.94|P-value:2.64E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-2.70|P-value:6.39E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:2.81|P-value:4.80E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.11|P-value:1.28E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.20|P-value:8.28E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:2.95|P-value:2.57E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:2.79|P-value:5.10E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.98|P-value:1.35E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:-2.67|P-value:7.03E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:-2.68|P-value:6.96E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-4.35|P-value:1.11E-7 ID:SGTC_933|Compound:2914-0560|FD-Score:2.79|P-value:5.08E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.80|P-value:5.02E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:2.99|P-value:2.14E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:2.78|P-value:5.26E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.39|P-value:1.08E-7 ID:SGTC_1305|Compound:1181-0477|FD-Score:2.90|P-value:3.21E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.78|P-value:4.25E-6 ID:SGTC_1526|Compound:st051518|FD-Score:-2.94|P-value:2.23E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.12|P-value:9.82E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.35|P-value:3.90E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-2.82|P-value:3.77E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.19|P-value:8.63E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-2.99|P-value:1.78E-4 ID:SGTC_2341|Compound:7987486|FD-Score:2.97|P-value:2.31E-4 ID:SGTC_2347|Compound:9049783|FD-Score:2.90|P-value:3.23E-4 ID:SGTC_2456|Compound:5770359|FD-Score:2.83|P-value:4.36E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.06|P-value:1.58E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.30|P-value:1.68E-73 ID:SGTC_2584|Compound:androsterone|FD-Score:9.63|P-value:2.39E-30 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-4.31|P-value:1.46E-7 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.72|P-value:6.98E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.06|P-value:1.31E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.63|P-value:7.77E-6 ID:SGTC_2814|Compound:7977482|FD-Score:4.14|P-value:5.25E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-4.00|P-value:9.18E-7 ID:SGTC_2954|Compound:9074818|FD-Score:2.67|P-value:8.57E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.28|P-value:4.60E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.16|P-value:9.70E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.79|P-value:3.20E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:2.94|P-value:2.64E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-2.70|P-value:6.39E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:2.81|P-value:4.80E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.11|P-value:1.28E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:3.20|P-value:8.28E-5 ID:SGTC_705|Compound:1124-0212|FD-Score:2.95|P-value:2.57E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:2.79|P-value:5.10E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:3.98|P-value:1.35E-6 ID:SGTC_801|Compound:0866-0028|FD-Score:-2.67|P-value:7.03E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:-2.68|P-value:6.96E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-4.35|P-value:1.11E-7 ID:SGTC_933|Compound:2914-0560|FD-Score:2.79|P-value:5.08E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.80|P-value:5.02E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:2.99|P-value:2.14E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:2.78|P-value:5.26E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:4.39|P-value:1.08E-7 ID:SGTC_1305|Compound:1181-0477|FD-Score:2.90|P-value:3.21E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:3.78|P-value:4.25E-6 ID:SGTC_1526|Compound:st051518|FD-Score:-2.94|P-value:2.23E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-3.12|P-value:9.82E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.35|P-value:3.90E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-2.82|P-value:3.77E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.19|P-value:8.63E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-2.99|P-value:1.78E-4 ID:SGTC_2341|Compound:7987486|FD-Score:2.97|P-value:2.31E-4 ID:SGTC_2347|Compound:9049783|FD-Score:2.90|P-value:3.23E-4 ID:SGTC_2456|Compound:5770359|FD-Score:2.83|P-value:4.36E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.06|P-value:1.58E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:15.30|P-value:1.68E-73 ID:SGTC_2584|Compound:androsterone|FD-Score:9.63|P-value:2.39E-30 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-4.31|P-value:1.46E-7 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.72|P-value:6.98E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.06|P-value:1.31E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.63|P-value:7.77E-6 ID:SGTC_2814|Compound:7977482|FD-Score:4.14|P-value:5.25E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-4.00|P-value:9.18E-7 ID:SGTC_2954|Compound:9074818|FD-Score:2.67|P-value:8.57E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.28|P-value:4.60E-5 ID:SGTC_3304|Compound:9125678|FD-Score:3.16|P-value:9.70E-5

Top fitness defect scores for YNL106C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 15.30 100.0 µM 1.68E-73 redox potentiating 15 4.58E-53
2 SGTC_2584 androsterone 9.63 48.7 µM 2.39E-30 cell wall 18 3.04E-22
3 SGTC_1268 0828-0275 4.39 2.5 µM 1.08E-7 13 5.54E-6
4 SGTC_2814 7977482 4.14 43.0 µM 5.25E-7 42 1.74E-5
5 SGTC_773 4358-1457 3.98 44.6 µM 1.35E-6 42 3.47E-5
6 SGTC_1467 k284-1082 3.78 293.0 µM 4.25E-6 22 7.95E-5
7 SGTC_1725 st036284 3.35 20.6 µM 3.90E-5 57 4.00E-4
8 SGTC_686 1319-0111 3.20 510.0 µM 8.28E-5 60S ribosome export 53 6.92E-4
9 SGTC_2126 5251174 3.19 33.9 µM 8.63E-5 75 7.14E-4
10 SGTC_3304 9125678 3.16 46.1 µM 9.70E-5 86 7.77E-4
11 SGTC_676 falcarinol 3.11 140.0 µM 1.28E-4 93 9.49E-4
12 SGTC_2521 angolensin 3.06 13.4 µM 1.58E-4 41 0.00111
13 SGTC_935 2996-0153 2.99 430.0 µM 2.14E-4 PDR1 62 0.00139
14 SGTC_2341 7987486 2.97 176.7 µM 2.31E-4 62 0.00147
15 SGTC_705 1124-0212 2.95 310.0 µM 2.57E-4 57 0.00159
16 SGTC_138 0850-0259 2.94 40.9 µM 2.64E-4 cell wall 282 0.00162
17 SGTC_1305 1181-0477 2.90 144.0 µM 3.21E-4 59 0.00187
18 SGTC_2347 9049783 2.90 174.8 µM 3.23E-4 95 0.00187
19 SGTC_2456 5770359 2.83 74.5 µM 4.36E-4 65 0.00234
20 SGTC_551 k048-0028 2.81 34.9 µM 4.80E-4 74 0.00251

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.422 1.59E-144 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.415 1.69E-139 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.404 8.48E-132 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.393 5.44E-124 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.373 2.58E-111 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.366 1.46E-106 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.365 2.58E-106 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.364 1.81E-105 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.358 1.38E-101 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.346 1.26E-94 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.345 4.37E-94 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.325 2.08E-83 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.325 4.47E-83 YOL013C HRD1 hom Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
0.323 2.53E-82 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.322 7.14E-82 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication