YNL111C / CYB5

Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL111C / CYB5

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:7.05|P-value:5.79E-9 ID:SGTC_36|Compound:0335-0881|FD-Score:12.70|P-value:4.47E-25 ID:SGTC_64|Compound:000l-0018|FD-Score:26.10|P-value:2.21E-99 ID:SGTC_67|Compound:0335-0847|FD-Score:12.70|P-value:3.80E-25 ID:SGTC_86|Compound:0417-1630|FD-Score:18.90|P-value:6.17E-53 ID:SGTC_87|Compound:0100-0052|FD-Score:5.01|P-value:2.56E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:4.61|P-value:9.64E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:3.85|P-value:9.17E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.67|P-value:7.95E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.26|P-value:2.87E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.07|P-value:4.87E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:20.10|P-value:7.21E-60 ID:SGTC_158|Compound:k038-0087|FD-Score:11.70|P-value:1.43E-21 ID:SGTC_165|Compound:k038-0023|FD-Score:6.85|P-value:1.49E-8 ID:SGTC_176|Compound:1486-1328|FD-Score:6.06|P-value:4.84E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:6.36|P-value:1.34E-7 ID:SGTC_187|Compound:1488-2104|FD-Score:8.18|P-value:1.79E-11 ID:SGTC_197|Compound:4544-0043|FD-Score:5.78|P-value:1.46E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:15.30|P-value:2.54E-35 ID:SGTC_216|Compound:k038-0035|FD-Score:15.30|P-value:2.41E-35 ID:SGTC_260|Compound:nsc-65238|FD-Score:6.03|P-value:5.32E-7 ID:SGTC_340|Compound:k038-0059|FD-Score:5.99|P-value:6.36E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:4.98|P-value:2.77E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.83|P-value:9.71E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.07|P-value:5.01E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-4.34|P-value:2.21E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.50|P-value:1.37E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.43|P-value:1.72E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:7.61|P-value:3.80E-10 ID:SGTC_761|Compound:k216-0224|FD-Score:3.84|P-value:9.46E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.41|P-value:1.77E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:9.97|P-value:3.61E-16 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.67|P-value:7.96E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:4.65|P-value:8.59E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.32|P-value:2.39E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.84|P-value:9.53E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:7.00|P-value:7.62E-9 ID:SGTC_1323|Compound:1348-1351|FD-Score:-4.21|P-value:3.22E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.21|P-value:3.31E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-5.40|P-value:6.07E-6 ID:SGTC_1396|Compound:3511-0007|FD-Score:-4.18|P-value:3.59E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.18|P-value:3.61E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:8.91|P-value:2.90E-13 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.07|P-value:2.09E-5 ID:SGTC_1687|Compound:st020778|FD-Score:7.22|P-value:2.59E-9 ID:SGTC_1694|Compound:st024011|FD-Score:3.89|P-value:8.22E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.02|P-value:2.45E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-4.14|P-value:3.97E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.18|P-value:3.66E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.52|P-value:6.56E-8 ID:SGTC_1976|Compound:st070609|FD-Score:-3.85|P-value:9.09E-4 ID:SGTC_2028|Compound:5153890|FD-Score:5.08|P-value:1.97E-5 ID:SGTC_2033|Compound:5192550|FD-Score:4.27|P-value:2.80E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.91|P-value:7.73E-4 ID:SGTC_2144|Compound:5628481|FD-Score:6.26|P-value:2.04E-7 ID:SGTC_2149|Compound:5554786|FD-Score:4.23|P-value:3.09E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.86|P-value:8.93E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.84|P-value:4.52E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.97|P-value:2.89E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.90|P-value:8.13E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-6.39|P-value:1.14E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.74|P-value:1.89E-10 ID:SGTC_2706|Compound:st078239|FD-Score:3.97|P-value:6.65E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.68|P-value:7.62E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:11.50|P-value:8.99E-21 ID:SGTC_2781|Compound:5567276|FD-Score:3.84|P-value:9.53E-4 ID:SGTC_2858|Compound:9025781|FD-Score:12.70|P-value:4.27E-25 ID:SGTC_2896|Compound:9052656|FD-Score:-4.43|P-value:1.65E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.91|P-value:7.79E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-4.95|P-value:3.06E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-5.36|P-value:7.23E-6 ID:SGTC_3065|Compound:9113888|FD-Score:5.43|P-value:5.57E-6 ID:SGTC_3076|Compound:9116187|FD-Score:3.84|P-value:9.60E-4 ID:SGTC_3155|Compound:9099265|FD-Score:4.06|P-value:5.08E-4 ID:SGTC_3246|Compound:9135460|FD-Score:5.05|P-value:2.18E-5 ID:SGTC_3277|Compound:9138724|FD-Score:5.04|P-value:2.32E-5 ID:SGTC_3303|Compound:9125618|FD-Score:4.01|P-value:5.86E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:7.05|P-value:5.79E-9 ID:SGTC_36|Compound:0335-0881|FD-Score:12.70|P-value:4.47E-25 ID:SGTC_64|Compound:000l-0018|FD-Score:26.10|P-value:2.21E-99 ID:SGTC_67|Compound:0335-0847|FD-Score:12.70|P-value:3.80E-25 ID:SGTC_86|Compound:0417-1630|FD-Score:18.90|P-value:6.17E-53 ID:SGTC_87|Compound:0100-0052|FD-Score:5.01|P-value:2.56E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:4.61|P-value:9.64E-5 ID:SGTC_114|Compound:0364-0001|FD-Score:3.85|P-value:9.17E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.67|P-value:7.95E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:4.26|P-value:2.87E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-4.07|P-value:4.87E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:20.10|P-value:7.21E-60 ID:SGTC_158|Compound:k038-0087|FD-Score:11.70|P-value:1.43E-21 ID:SGTC_165|Compound:k038-0023|FD-Score:6.85|P-value:1.49E-8 ID:SGTC_176|Compound:1486-1328|FD-Score:6.06|P-value:4.84E-7 ID:SGTC_177|Compound:1327-0068|FD-Score:6.36|P-value:1.34E-7 ID:SGTC_187|Compound:1488-2104|FD-Score:8.18|P-value:1.79E-11 ID:SGTC_197|Compound:4544-0043|FD-Score:5.78|P-value:1.46E-6 ID:SGTC_200|Compound:k038-0079|FD-Score:15.30|P-value:2.54E-35 ID:SGTC_216|Compound:k038-0035|FD-Score:15.30|P-value:2.41E-35 ID:SGTC_260|Compound:nsc-65238|FD-Score:6.03|P-value:5.32E-7 ID:SGTC_340|Compound:k038-0059|FD-Score:5.99|P-value:6.36E-7 ID:SGTC_367|Compound:0335-0881|FD-Score:4.98|P-value:2.77E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.83|P-value:9.71E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.07|P-value:5.01E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-4.34|P-value:2.21E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:4.50|P-value:1.37E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.43|P-value:1.72E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:7.61|P-value:3.80E-10 ID:SGTC_761|Compound:k216-0224|FD-Score:3.84|P-value:9.46E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.41|P-value:1.77E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:9.97|P-value:3.61E-16 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.67|P-value:7.96E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:4.65|P-value:8.59E-5 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:4.32|P-value:2.39E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.84|P-value:9.53E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:7.00|P-value:7.62E-9 ID:SGTC_1323|Compound:1348-1351|FD-Score:-4.21|P-value:3.22E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:4.21|P-value:3.31E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-5.40|P-value:6.07E-6 ID:SGTC_1396|Compound:3511-0007|FD-Score:-4.18|P-value:3.59E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:4.18|P-value:3.61E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:8.91|P-value:2.90E-13 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.07|P-value:2.09E-5 ID:SGTC_1687|Compound:st020778|FD-Score:7.22|P-value:2.59E-9 ID:SGTC_1694|Compound:st024011|FD-Score:3.89|P-value:8.22E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.02|P-value:2.45E-5 ID:SGTC_1750|Compound:st081859|FD-Score:-4.14|P-value:3.97E-4 ID:SGTC_1769|Compound:st044406|FD-Score:4.18|P-value:3.66E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:6.52|P-value:6.56E-8 ID:SGTC_1976|Compound:st070609|FD-Score:-3.85|P-value:9.09E-4 ID:SGTC_2028|Compound:5153890|FD-Score:5.08|P-value:1.97E-5 ID:SGTC_2033|Compound:5192550|FD-Score:4.27|P-value:2.80E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.91|P-value:7.73E-4 ID:SGTC_2144|Compound:5628481|FD-Score:6.26|P-value:2.04E-7 ID:SGTC_2149|Compound:5554786|FD-Score:4.23|P-value:3.09E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.86|P-value:8.93E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.84|P-value:4.52E-5 ID:SGTC_2322|Compound:7413319|FD-Score:4.97|P-value:2.89E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.90|P-value:8.13E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-6.39|P-value:1.14E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.74|P-value:1.89E-10 ID:SGTC_2706|Compound:st078239|FD-Score:3.97|P-value:6.65E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:4.68|P-value:7.62E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:11.50|P-value:8.99E-21 ID:SGTC_2781|Compound:5567276|FD-Score:3.84|P-value:9.53E-4 ID:SGTC_2858|Compound:9025781|FD-Score:12.70|P-value:4.27E-25 ID:SGTC_2896|Compound:9052656|FD-Score:-4.43|P-value:1.65E-4 ID:SGTC_2950|Compound:9072895|FD-Score:-3.91|P-value:7.79E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-4.95|P-value:3.06E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-5.36|P-value:7.23E-6 ID:SGTC_3065|Compound:9113888|FD-Score:5.43|P-value:5.57E-6 ID:SGTC_3076|Compound:9116187|FD-Score:3.84|P-value:9.60E-4 ID:SGTC_3155|Compound:9099265|FD-Score:4.06|P-value:5.08E-4 ID:SGTC_3246|Compound:9135460|FD-Score:5.05|P-value:2.18E-5 ID:SGTC_3277|Compound:9138724|FD-Score:5.04|P-value:2.32E-5 ID:SGTC_3303|Compound:9125618|FD-Score:4.01|P-value:5.86E-4

Top fitness defect scores for YNL111C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 26.10 272.1 µM 2.21E-99 ubiquinone biosynthesis & proteasome 4 1.33E-150
2 SGTC_142 0335-0849 20.10 62.7 µM 7.21E-60 ubiquinone biosynthesis & proteasome 5 2.60E-90
3 SGTC_86 0417-1630 18.90 471.9 µM 6.17E-53 ubiquinone biosynthesis & proteasome 5 9.77E-80
4 SGTC_216 k038-0035 15.30 28.4 µM 2.41E-35 ubiquinone biosynthesis & proteasome 1 6.48E-53
5 SGTC_200 k038-0079 15.30 37.5 µM 2.54E-35 ubiquinone biosynthesis & proteasome 1 7.05E-53
6 SGTC_67 0335-0847 12.70 266.0 µM 3.80E-25 ubiquinone biosynthesis & proteasome 14 2.23E-37
7 SGTC_2858 9025781 12.70 9.0 µM 4.27E-25 sphingolipid biosynthesis & PDR1 14 2.66E-37
8 SGTC_36 0335-0881 12.70 14.2 µM 4.47E-25 ubiquinone biosynthesis & proteasome 13 2.85E-37
9 SGTC_158 k038-0087 11.70 26.4 µM 1.43E-21 ubiquinone biosynthesis & proteasome 23 6.20E-32
10 SGTC_2752 diclazuril 11.50 33.1 µM 8.99E-21 18 1.01E-30
11 SGTC_794 k038-0031 9.97 316.0 µM 3.61E-16 ubiquinone biosynthesis & proteasome 19 1.02E-23
12 SGTC_1495 4469-0029 8.91 237.0 µM 2.90E-13 19 2.64E-19
13 SGTC_187 1488-2104 8.18 32.7 µM 1.79E-11 calcium & mitochondrial duress 8 1.38E-16
14 SGTC_2688 kanamycin b 7.74 96.7 µM 1.89E-10 calcium & mitochondrial duress 75 4.90E-15
15 SGTC_598 3937-0236 7.61 20.2 µM 3.80E-10 ERG2 6 1.41E-14
16 SGTC_1687 st020778 7.22 55.4 µM 2.59E-9 84 2.58E-13
17 SGTC_8 0354-0001 7.05 70.0 µM 5.79E-9 18 8.72E-13
18 SGTC_1304 1165-0502 7.00 251.0 µM 7.62E-9 21 1.32E-12
19 SGTC_165 k038-0023 6.85 64.4 µM 1.49E-8 ubiquinone biosynthesis & proteasome 14 3.65E-12
20 SGTC_1877 wortmannin 6.52 25.0 µM 6.56E-8 41 3.42E-11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.521 5.92E-233 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.513 9.46E-224 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.503 2.15E-214 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.493 3.28E-205 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.492 3.28E-204 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.484 1.15E-196 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.480 5.77E-193 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.477 2.36E-190 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.463 1.51E-177 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.457 1.04E-172 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.451 1.40E-167 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.445 4.99E-163 YPR065W ROX1 hom Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.445 1.37E-162 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.436 1.64E-155 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.429 2.04E-150 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene