HIPHOP chemogenomics database
YNL113W / RPC19 
RNA polymerase subunit AC19, common to RNA polymerases I and III
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YNL113W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.104 | 1.80E-9 | YKL102C_d | YKL102C_d | hom | Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site |
| 0.102 | 2.98E-9 | YDR398W | UTP5 | het | Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit |
| 0.097 | 2.17E-8 | YIL127C_p | RRT14_p | hom | Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis |
| 0.094 | 5.13E-8 | YJL108C | PRM10 | hom | Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation |
| 0.089 | 2.52E-7 | YOR210W | RPB10 | het | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
| 0.086 | 5.33E-7 | YKR017C | HEL1 | hom | RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU) |
| 0.086 | 6.84E-7 | YPR137W | RRP9 | het | Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein |
| 0.081 | 2.43E-6 | YER091C | MET6 | hom | Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs |
| 0.079 | 4.11E-6 | YLR198C_d | YLR198C_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W |
| 0.078 | 6.64E-6 | YPL092W | SSU1 | hom | Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein |
| 0.077 | 8.10E-6 | YLL048C | YBT1 | hom | Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters |
| 0.076 | 9.38E-6 | YGR168C_p | YGR168C_p | hom | Putative protein of unknown function; YGR168C is not an essential gene |
| 0.076 | 1.04E-5 | YJL024C | APS3 | hom | Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress |
| 0.075 | 1.25E-5 | YPL178W | CBC2 | hom | Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif |
| 0.075 | 1.30E-5 | YAL058W | CNE1 | hom | Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast |