YNL115C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL115C / YNL115C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:10.40|P-value:2.43E-28 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.30|P-value:2.34E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:2.95|P-value:8.98E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:2.95|P-value:8.87E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.41|P-value:1.51E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.12|P-value:4.71E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.48|P-value:1.14E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.60|P-value:6.74E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.83|P-value:2.50E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.99|P-value:6.16E-8 ID:SGTC_746|Compound:1095-0025|FD-Score:7.87|P-value:3.83E-17 ID:SGTC_768|Compound:0384-0033|FD-Score:3.70|P-value:4.46E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.24|P-value:2.98E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.85|P-value:2.33E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.45|P-value:1.30E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.36|P-value:1.88E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.66|P-value:5.41E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.50|P-value:1.04E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.57|P-value:6.34E-7 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.30|P-value:2.34E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.44|P-value:1.33E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.05|P-value:6.18E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.00|P-value:7.48E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-2.92|P-value:9.87E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.20|P-value:3.50E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.17|P-value:4.00E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.79|P-value:3.03E-5 ID:SGTC_1987|Compound:st072290|FD-Score:3.84|P-value:2.42E-5 ID:SGTC_1992|Compound:st073643|FD-Score:-3.42|P-value:1.48E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.64|P-value:5.91E-5 ID:SGTC_2050|Compound:5263056|FD-Score:3.57|P-value:7.85E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:2.95|P-value:8.77E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.37|P-value:1.76E-4 ID:SGTC_2219|Compound:9098279|FD-Score:3.00|P-value:7.40E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-3.04|P-value:6.36E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.58|P-value:7.35E-5 ID:SGTC_2327|Compound:6189656|FD-Score:3.37|P-value:1.79E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.08|P-value:5.47E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-4.10|P-value:7.16E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.92|P-value:1.62E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.92|P-value:9.92E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.86|P-value:2.18E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.10|P-value:5.19E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.02|P-value:6.83E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.29|P-value:2.46E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.84|P-value:2.41E-5 ID:SGTC_3037|Compound:9091026|FD-Score:2.98|P-value:8.03E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-4.01|P-value:1.08E-5 ID:SGTC_3210|Compound:9128157|FD-Score:3.13|P-value:4.56E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:10.40|P-value:2.43E-28 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.30|P-value:2.34E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:2.95|P-value:8.98E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:2.95|P-value:8.87E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.41|P-value:1.51E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.12|P-value:4.71E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.48|P-value:1.14E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:3.60|P-value:6.74E-5 ID:SGTC_658|Compound:3253-0951|FD-Score:3.83|P-value:2.50E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.99|P-value:6.16E-8 ID:SGTC_746|Compound:1095-0025|FD-Score:7.87|P-value:3.83E-17 ID:SGTC_768|Compound:0384-0033|FD-Score:3.70|P-value:4.46E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.24|P-value:2.98E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.85|P-value:2.33E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.45|P-value:1.30E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:3.36|P-value:1.88E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.66|P-value:5.41E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.50|P-value:1.04E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:-4.57|P-value:6.34E-7 ID:SGTC_1385|Compound:3091-4834|FD-Score:3.30|P-value:2.34E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.44|P-value:1.33E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.05|P-value:6.18E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.00|P-value:7.48E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-2.92|P-value:9.87E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.20|P-value:3.50E-4 ID:SGTC_1822|Compound:st052468|FD-Score:-3.17|P-value:4.00E-4 ID:SGTC_1909|Compound:st060837|FD-Score:3.79|P-value:3.03E-5 ID:SGTC_1987|Compound:st072290|FD-Score:3.84|P-value:2.42E-5 ID:SGTC_1992|Compound:st073643|FD-Score:-3.42|P-value:1.48E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.64|P-value:5.91E-5 ID:SGTC_2050|Compound:5263056|FD-Score:3.57|P-value:7.85E-5 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:2.95|P-value:8.77E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.37|P-value:1.76E-4 ID:SGTC_2219|Compound:9098279|FD-Score:3.00|P-value:7.40E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-3.04|P-value:6.36E-4 ID:SGTC_2322|Compound:7413319|FD-Score:3.58|P-value:7.35E-5 ID:SGTC_2327|Compound:6189656|FD-Score:3.37|P-value:1.79E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.08|P-value:5.47E-4 ID:SGTC_2416|Compound:tofa|FD-Score:-4.10|P-value:7.16E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.92|P-value:1.62E-5 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:2.92|P-value:9.92E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.86|P-value:2.18E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.10|P-value:5.19E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.02|P-value:6.83E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.29|P-value:2.46E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.84|P-value:2.41E-5 ID:SGTC_3037|Compound:9091026|FD-Score:2.98|P-value:8.03E-4 ID:SGTC_3098|Compound:9119039|FD-Score:-4.01|P-value:1.08E-5 ID:SGTC_3210|Compound:9128157|FD-Score:3.13|P-value:4.56E-4

Top fitness defect scores for YNL115C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 10.40 9.0 µM 2.43E-28 cell wall 72 1.77E-25
2 SGTC_746 1095-0025 7.87 46.6 µM 3.83E-17 RSC & ERG11 2 1.75E-15
3 SGTC_742 0kpi-0133 4.99 140.0 µM 6.16E-8 ERG2 8 2.96E-7
4 SGTC_2688 kanamycin b 3.86 96.7 µM 2.18E-5 calcium & mitochondrial duress 386 5.68E-5
5 SGTC_874 0599-0792 3.85 117.0 µM 2.33E-5 30 6.02E-5
6 SGTC_2985 9022375 3.84 71.4 µM 2.41E-5 RPP1 & pyrimidine depletion 34 6.20E-5
7 SGTC_1987 st072290 3.84 61.9 µM 2.42E-5 17 6.22E-5
8 SGTC_658 3253-0951 3.83 102.0 µM 2.50E-5 calcium & mitochondrial duress 65 6.41E-5
9 SGTC_1909 st060837 3.79 51.5 µM 3.03E-5 61 7.63E-5
10 SGTC_768 0384-0033 3.70 77.3 µM 4.46E-5 fatty acid desaturase (OLE1) 92 1.08E-4
11 SGTC_1308 1187-1617 3.66 41.4 µM 5.41E-5 fatty acid desaturase (OLE1) 52 1.28E-4
12 SGTC_1994 st072947 3.64 40.9 µM 5.91E-5 26 1.39E-4
13 SGTC_649 1123-0311 3.60 367.0 µM 6.74E-5 endomembrane recycling 87 1.56E-4
14 SGTC_2322 7413319 3.58 38.2 µM 7.35E-5 ERAD & cell cycle 181 1.69E-4
15 SGTC_2050 5263056 3.57 171.0 µM 7.85E-5 fatty acid desaturase (OLE1) 60 1.79E-4
16 SGTC_1319 1306-0155 3.50 43.7 µM 1.04E-4 39 2.30E-4
17 SGTC_534 k292-0788 3.48 63.4 µM 1.14E-4 mitochondrial processes 46 2.49E-4
18 SGTC_908 3448-7491 3.45 47.7 µM 1.30E-4 mitochondrial stress 156 2.81E-4
19 SGTC_1392 3455-1037 3.44 33.9 µM 1.33E-4 29 2.87E-4
20 SGTC_457 grayanotoxin iii 3.41 135.0 µM 1.51E-4 102 3.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.283 1.15E-62 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.281 4.36E-62 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.264 1.80E-54 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.252 8.00E-50 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
0.244 1.10E-46 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.241 1.13E-45 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.232 2.57E-42 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.228 5.83E-41 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.227 1.39E-40 YIL148W RPL40A hom Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.225 1.06E-39 YML021C UNG1 hom Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
0.221 1.71E-38 YOR179C SYC1 hom Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication
0.220 6.97E-38 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.218 1.91E-37 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.216 1.03E-36 YBR286W APE3 hom Vacuolar aminopeptidase Y, processed to mature form by Prb1p
0.214 3.65E-36 YBR291C CTP1 hom Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family