YNL128W / TEP1

PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL128W / TEP1

Click on Significant Values for Screen Details ID:SGTC_195|Compound:4234-0266|FD-Score:2.96|P-value:7.47E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.18|P-value:3.36E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.85|P-value:1.80E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.00|P-value:6.47E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.56|P-value:6.67E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:2.98|P-value:6.95E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.41|P-value:1.27E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:2.99|P-value:6.67E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.32|P-value:1.83E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:8.40|P-value:1.06E-19 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.06|P-value:5.06E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:-3.22|P-value:2.85E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:-3.43|P-value:1.19E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:-3.02|P-value:6.09E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.21|P-value:2.79E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.34|P-value:1.66E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.00|P-value:6.30E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:2.93|P-value:8.41E-4 ID:SGTC_1640|Compound:st009078|FD-Score:4.30|P-value:1.96E-6 ID:SGTC_1654|Compound:st012436|FD-Score:3.47|P-value:9.88E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.79|P-value:2.52E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.27|P-value:2.20E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.37|P-value:1.54E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.08|P-value:4.76E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-4.63|P-value:3.47E-7 ID:SGTC_1988|Compound:st071872|FD-Score:3.08|P-value:4.73E-4 ID:SGTC_1989|Compound:st071868|FD-Score:4.06|P-value:6.49E-6 ID:SGTC_2178|Compound:5812956|FD-Score:-3.30|P-value:2.06E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.53|P-value:7.47E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.36|P-value:1.57E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.14|P-value:4.35E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.26|P-value:2.46E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.55|P-value:7.23E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.61|P-value:5.50E-5 ID:SGTC_2699|Compound:st077704|FD-Score:4.60|P-value:3.96E-7 ID:SGTC_2703|Compound:st077852|FD-Score:-4.81|P-value:1.28E-7 ID:SGTC_2706|Compound:st078239|FD-Score:3.30|P-value:1.94E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.28|P-value:2.26E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.23|P-value:2.76E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-4.38|P-value:1.35E-6 ID:SGTC_2859|Compound:9028643|FD-Score:3.93|P-value:1.24E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-5.83|P-value:2.04E-10 ID:SGTC_2991|Compound:9074669|FD-Score:5.02|P-value:3.67E-8 ID:SGTC_2996|Compound:9066192|FD-Score:3.17|P-value:3.30E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.05|P-value:5.23E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.25|P-value:2.40E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.16|P-value:3.39E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-2.92|P-value:8.76E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.30|P-value:1.99E-4 ID:SGTC_195|Compound:4234-0266|FD-Score:2.96|P-value:7.47E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:-3.18|P-value:3.36E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.85|P-value:1.80E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.00|P-value:6.47E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.56|P-value:6.67E-5 ID:SGTC_627|Compound:1391-0720|FD-Score:2.98|P-value:6.95E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.41|P-value:1.27E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:2.99|P-value:6.67E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:3.32|P-value:1.83E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:8.40|P-value:1.06E-19 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.06|P-value:5.06E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:-3.22|P-value:2.85E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:-3.43|P-value:1.19E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:-3.02|P-value:6.09E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.21|P-value:2.79E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.34|P-value:1.66E-4 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.00|P-value:6.30E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:2.93|P-value:8.41E-4 ID:SGTC_1640|Compound:st009078|FD-Score:4.30|P-value:1.96E-6 ID:SGTC_1654|Compound:st012436|FD-Score:3.47|P-value:9.88E-5 ID:SGTC_1745|Compound:st081495|FD-Score:-3.79|P-value:2.52E-5 ID:SGTC_1779|Compound:st039427|FD-Score:3.27|P-value:2.20E-4 ID:SGTC_1898|Compound:st060199|FD-Score:-3.37|P-value:1.54E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.08|P-value:4.76E-4 ID:SGTC_1977|Compound:st070720|FD-Score:-4.63|P-value:3.47E-7 ID:SGTC_1988|Compound:st071872|FD-Score:3.08|P-value:4.73E-4 ID:SGTC_1989|Compound:st071868|FD-Score:4.06|P-value:6.49E-6 ID:SGTC_2178|Compound:5812956|FD-Score:-3.30|P-value:2.06E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.53|P-value:7.47E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.36|P-value:1.57E-4 ID:SGTC_2663|Compound:amphotericin b|FD-Score:4.14|P-value:4.35E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.26|P-value:2.46E-4 ID:SGTC_2691|Compound:st077356|FD-Score:-3.55|P-value:7.23E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.61|P-value:5.50E-5 ID:SGTC_2699|Compound:st077704|FD-Score:4.60|P-value:3.96E-7 ID:SGTC_2703|Compound:st077852|FD-Score:-4.81|P-value:1.28E-7 ID:SGTC_2706|Compound:st078239|FD-Score:3.30|P-value:1.94E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-3.28|P-value:2.26E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.23|P-value:2.76E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-4.38|P-value:1.35E-6 ID:SGTC_2859|Compound:9028643|FD-Score:3.93|P-value:1.24E-5 ID:SGTC_2943|Compound:9068529|FD-Score:-5.83|P-value:2.04E-10 ID:SGTC_2991|Compound:9074669|FD-Score:5.02|P-value:3.67E-8 ID:SGTC_2996|Compound:9066192|FD-Score:3.17|P-value:3.30E-4 ID:SGTC_3153|Compound:9100258|FD-Score:3.05|P-value:5.23E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.25|P-value:2.40E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.16|P-value:3.39E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-2.92|P-value:8.76E-4 ID:SGTC_3332|Compound:9141069|FD-Score:3.30|P-value:1.99E-4

Top fitness defect scores for YNL128W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1294 1000-1494 8.40 117.0 µM 1.06E-19 13 2.32E-17
2 SGTC_2991 9074669 5.02 71.4 µM 3.67E-8 azole & statin 32 2.65E-7
3 SGTC_2699 st077704 4.60 54.6 µM 3.96E-7 endomembrane recycling 35 2.11E-6
4 SGTC_1640 st009078 4.30 66.4 µM 1.96E-6 6 8.54E-6
5 SGTC_2663 amphotericin b 4.14 100.0 µM 4.35E-6 10 1.71E-5
6 SGTC_1989 st071868 4.06 50.2 µM 6.49E-6 11 2.43E-5
7 SGTC_2859 9028643 3.93 45.5 µM 1.24E-5 14 4.29E-5
8 SGTC_385 1494-0393 3.85 12.4 µM 1.80E-5 27 5.93E-5
9 SGTC_580 1123-0028 3.56 41.0 µM 6.67E-5 DNA damage response 52 1.87E-4
10 SGTC_2308 7584454 3.53 197.6 µM 7.47E-5 37 2.06E-4
11 SGTC_1654 st012436 3.47 41.8 µM 9.88E-5 27 2.63E-4
12 SGTC_1124 fisetin 3.41 1.2 µM 1.27E-4 56 3.28E-4
13 SGTC_2564 betulinic acid 3.36 100.0 µM 1.57E-4 56 3.95E-4
14 SGTC_1433 4060-0023 3.34 7.6 µM 1.66E-4 tubulin folding & SWR complex 32 4.14E-4
15 SGTC_1166 k206-0078 3.32 225.0 µM 1.83E-4 43 4.53E-4
16 SGTC_2706 st078239 3.30 82.5 µM 1.94E-4 33 4.75E-4
17 SGTC_3332 9141069 3.30 11.2 µM 1.99E-4 36 4.86E-4
18 SGTC_1779 st039427 3.27 55.0 µM 2.20E-4 53 5.30E-4
19 SGTC_3209 9113616 3.25 49.5 µM 2.40E-4 61 5.73E-4
20 SGTC_1432 4049-0298 3.21 68.4 µM 2.79E-4 25 6.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.297 2.97E-69 YDL207W GLE1 het Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
0.187 8.71E-28 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.160 1.02E-20 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.152 6.87E-19 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.124 6.52E-13 YOR066W MSA1 hom Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
0.115 2.33E-11 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.104 1.69E-9 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.103 2.47E-9 YPR174C YPR174C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication
0.100 6.12E-9 YLL023C POM33 hom Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress
0.098 1.29E-8 YIL097W FYV10 hom Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin
0.097 1.94E-8 YBL055C YBL055C hom 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
0.091 1.17E-7 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.091 1.17E-7 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.090 1.66E-7 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family
0.086 6.67E-7 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene