YNL129W / NRK1

Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL129W / NRK1

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.13|P-value:2.38E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.68|P-value:7.98E-8 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.10|P-value:2.59E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-4.86|P-value:2.53E-8 ID:SGTC_183|Compound:3914-0051|FD-Score:3.14|P-value:2.24E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-2.83|P-value:7.45E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.19|P-value:1.87E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.44|P-value:6.12E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.19|P-value:1.86E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.82|P-value:9.70E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.15|P-value:2.19E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.18|P-value:1.82E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.15|P-value:1.76E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.53|P-value:3.84E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.04|P-value:3.33E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-2.80|P-value:8.44E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.63|P-value:2.37E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.13|P-value:2.24E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.16|P-value:2.10E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.89|P-value:6.26E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.82|P-value:3.60E-8 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.09|P-value:2.70E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.47|P-value:5.22E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-2.93|P-value:5.05E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.46|P-value:5.55E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-2.84|P-value:7.16E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.13|P-value:2.38E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.68|P-value:7.98E-8 ID:SGTC_162|Compound:k030-0015|FD-Score:-3.10|P-value:2.59E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-4.86|P-value:2.53E-8 ID:SGTC_183|Compound:3914-0051|FD-Score:3.14|P-value:2.24E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:-2.83|P-value:7.45E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.19|P-value:1.87E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.44|P-value:6.12E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.19|P-value:1.86E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.82|P-value:9.70E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.15|P-value:2.19E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.18|P-value:1.82E-4 ID:SGTC_1399|Compound:3562-5772|FD-Score:4.15|P-value:1.76E-6 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.53|P-value:3.84E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.04|P-value:3.33E-4 ID:SGTC_1719|Compound:st032227|FD-Score:-2.80|P-value:8.44E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.63|P-value:2.37E-5 ID:SGTC_2018|Compound:5133068|FD-Score:-3.13|P-value:2.24E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.16|P-value:2.10E-4 ID:SGTC_2493|Compound:resveratrol|FD-Score:2.89|P-value:6.26E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:4.82|P-value:3.60E-8 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.09|P-value:2.70E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:3.47|P-value:5.22E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-2.93|P-value:5.05E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.46|P-value:5.55E-5 ID:SGTC_3317|Compound:9138495|FD-Score:-2.84|P-value:7.16E-4

Top fitness defect scores for YNL129W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2605 digitonin 4.82 300.0 nM 3.60E-8 10 7.20E-7
2 SGTC_1399 3562-5772 4.15 25.0 µM 1.76E-6 RPP1 & pyrimidine depletion 16 1.66E-5
3 SGTC_1246 0422-0085 3.82 105.0 µM 9.70E-6 34 6.58E-5
4 SGTC_2608 thymoquinone 3.47 42.7 µM 5.22E-5 29 2.57E-4
5 SGTC_3202 9113761 3.46 49.5 µM 5.55E-5 67 2.70E-4
6 SGTC_426 0988-0037 3.44 14.6 µM 6.12E-5 ERAD & cell cycle 55 2.92E-4
7 SGTC_1236 0330-0013 3.19 258.0 µM 1.86E-4 34 7.20E-4
8 SGTC_270 tamoxifen 3.19 5.5 µM 1.87E-4 NEO1 70 7.21E-4
9 SGTC_2462 5162487 3.16 171.8 µM 2.10E-4 41 7.94E-4
10 SGTC_1261 0712-0010 3.15 12.7 µM 2.19E-4 RNA processing & uracil transport 59 8.23E-4
11 SGTC_183 3914-0051 3.14 30.6 µM 2.24E-4 60S ribosome export 57 8.35E-4
12 SGTC_38 0929-0051 3.13 58.3 µM 2.38E-4 59 8.79E-4
13 SGTC_2493 resveratrol 2.89 26.1 µM 6.26E-4 42 0.00193
14 SGTC_2616 abietic acid 2.75 100.0 µM 0.00107 86 0.00299
15 SGTC_358 0075-0058 2.74 9.4 µM 0.00112 163 0.00309
16 SGTC_150 3970-0969 2.71 77.2 µM 0.00123 165 0.00333
17 SGTC_2166 5933061 2.71 31.5 µM 0.00126 tubulin folding & SWR complex 117 0.00341
18 SGTC_2491 paeonol 2.70 100.0 µM 0.00129 44 0.00347
19 SGTC_1117 retinoic acid 2.69 1.1 µM 0.00135 71 0.00360
20 SGTC_1451 4152-0210 2.69 104.0 µM 0.00136 112 0.00362

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.229 5.50E-41 YDR133C_d YDR133C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
0.207 7.18E-34 YGL249W ZIP2 hom Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.180 7.30E-26 YDR191W HST4 hom Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
0.177 4.46E-25 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.175 2.00E-24 YJR080C AIM24 hom Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss
0.157 5.11E-20 YKL100C_p YKL100C_p hom Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene
0.148 7.33E-18 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.146 2.42E-17 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.142 1.57E-16 YBL019W APN2 hom Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII
0.141 2.51E-16 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.136 3.67E-15 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.136 3.21E-15 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.133 1.27E-14 YER039C HVG1 hom Protein of unknown function, has homology to Vrg4p
0.131 2.41E-14 YDR330W UBX5 hom UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
0.130 4.00E-14 YJR082C EAF6 hom Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3