YNL135C / FPR1

Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL135C / FPR1

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:6.22|P-value:2.76E-9 ID:SGTC_31|Compound:0508-1974|FD-Score:4.29|P-value:2.90E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.95|P-value:1.78E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:4.75|P-value:4.20E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:3.60|P-value:3.73E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.77|P-value:2.06E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.71|P-value:2.52E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:7.42|P-value:1.73E-12 ID:SGTC_304|Compound:1310-0298|FD-Score:4.50|P-value:1.23E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.61|P-value:3.60E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:5.25|P-value:4.26E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:3.36|P-value:8.27E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.63|P-value:3.40E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.33|P-value:9.07E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.80|P-value:1.79E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.51|P-value:5.08E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.52|P-value:4.96E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.17|P-value:4.70E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:5.24|P-value:4.55E-7 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.49|P-value:5.40E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.65|P-value:3.15E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-16.60|P-value:5.55E-55 ID:SGTC_1870|Compound:st057514|FD-Score:4.45|P-value:1.53E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.66|P-value:3.05E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.82|P-value:1.76E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.68|P-value:2.88E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.34|P-value:8.86E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.77|P-value:3.93E-6 ID:SGTC_2334|Compound:9017922|FD-Score:-8.34|P-value:2.35E-15 ID:SGTC_2337|Compound:9009472|FD-Score:-5.59|P-value:7.49E-8 ID:SGTC_2373|Compound:9071805|FD-Score:3.54|P-value:4.57E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.93|P-value:1.18E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.79|P-value:1.96E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.17|P-value:4.62E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.31|P-value:9.84E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.27|P-value:3.95E-7 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-4.89|P-value:2.12E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.56|P-value:4.12E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.65|P-value:3.21E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.01|P-value:1.34E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-16.00|P-value:2.57E-51 ID:SGTC_2709|Compound:st078560|FD-Score:-3.38|P-value:7.31E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:8.36|P-value:2.32E-15 ID:SGTC_2769|Compound:toremifene|FD-Score:3.70|P-value:2.65E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.41|P-value:6.93E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.79|P-value:1.81E-4 ID:SGTC_3129|Compound:9127257|FD-Score:5.98|P-value:1.02E-8 ID:SGTC_11|Compound:0438-0307|FD-Score:6.22|P-value:2.76E-9 ID:SGTC_31|Compound:0508-1974|FD-Score:4.29|P-value:2.90E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:4.95|P-value:1.78E-6 ID:SGTC_65|Compound:0798-0905|FD-Score:4.75|P-value:4.20E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:3.60|P-value:3.73E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.77|P-value:2.06E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.71|P-value:2.52E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:7.42|P-value:1.73E-12 ID:SGTC_304|Compound:1310-0298|FD-Score:4.50|P-value:1.23E-5 ID:SGTC_363|Compound:0455-0021|FD-Score:3.61|P-value:3.60E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:5.25|P-value:4.26E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:3.36|P-value:8.27E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.63|P-value:3.40E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.33|P-value:9.07E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.80|P-value:1.79E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:3.51|P-value:5.08E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.52|P-value:4.96E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:4.17|P-value:4.70E-5 ID:SGTC_1268|Compound:0828-0275|FD-Score:5.24|P-value:4.55E-7 ID:SGTC_1409|Compound:3909-8004|FD-Score:3.49|P-value:5.40E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.65|P-value:3.15E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:-16.60|P-value:5.55E-55 ID:SGTC_1870|Compound:st057514|FD-Score:4.45|P-value:1.53E-5 ID:SGTC_2002|Compound:4023503|FD-Score:3.66|P-value:3.05E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.82|P-value:1.76E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.68|P-value:2.88E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.34|P-value:8.86E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.77|P-value:3.93E-6 ID:SGTC_2334|Compound:9017922|FD-Score:-8.34|P-value:2.35E-15 ID:SGTC_2337|Compound:9009472|FD-Score:-5.59|P-value:7.49E-8 ID:SGTC_2373|Compound:9071805|FD-Score:3.54|P-value:4.57E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.93|P-value:1.18E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.79|P-value:1.96E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.17|P-value:4.62E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.31|P-value:9.84E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:5.27|P-value:3.95E-7 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-4.89|P-value:2.12E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.56|P-value:4.12E-4 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.65|P-value:3.21E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.01|P-value:1.34E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-16.00|P-value:2.57E-51 ID:SGTC_2709|Compound:st078560|FD-Score:-3.38|P-value:7.31E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:8.36|P-value:2.32E-15 ID:SGTC_2769|Compound:toremifene|FD-Score:3.70|P-value:2.65E-4 ID:SGTC_2805|Compound:7950783|FD-Score:3.41|P-value:6.93E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.79|P-value:1.81E-4 ID:SGTC_3129|Compound:9127257|FD-Score:5.98|P-value:1.02E-8

Top fitness defect scores for YNL135C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2754 granisetron 8.36 64.0 µM 2.32E-15 2 3.18E-17
2 SGTC_181 1447-1644 7.42 8.1 µM 1.73E-12 endomembrane recycling 8 5.76E-14
3 SGTC_11 0438-0307 6.22 1.3 µM 2.76E-9 1 2.47E-10
4 SGTC_3129 9127257 5.98 49.5 µM 1.02E-8 4 1.09E-9
5 SGTC_2540 epiandrosterone 5.27 100.0 µM 3.95E-7 28 6.84E-8
6 SGTC_385 1494-0393 5.25 12.4 µM 4.26E-7 5 7.45E-8
7 SGTC_1268 0828-0275 5.24 2.5 µM 4.55E-7 4 8.02E-8
8 SGTC_2651 1327-0036 5.01 5.0 µM 1.34E-6 107 2.73E-7
9 SGTC_58 0957-0393 4.95 9.0 µM 1.78E-6 cell wall 289 3.76E-7
10 SGTC_2313 7726885 4.77 200.0 µM 3.93E-6 RPP1 & pyrimidine depletion 19 9.21E-7
11 SGTC_65 0798-0905 4.75 35.0 µM 4.20E-6 calcium & mitochondrial duress 58 9.94E-7
12 SGTC_304 1310-0298 4.50 97.0 µM 1.23E-5 cell wall 40 3.34E-6
13 SGTC_1870 st057514 4.45 26.5 µM 1.53E-5 RSC & ERG11 14 4.30E-6
14 SGTC_31 0508-1974 4.29 57.2 µM 2.90E-5 20 8.84E-6
15 SGTC_2397 5161689 4.17 200.0 µM 4.62E-5 27 1.50E-5
16 SGTC_1089 terbinafine 4.17 2.2 µM 4.70E-5 10 1.52E-5
17 SGTC_2380 9035439 3.93 200.0 µM 1.18E-4 endomembrane recycling 24 4.30E-5
18 SGTC_2085 5307070 3.82 144.1 µM 1.76E-4 superoxide 33 6.77E-5
19 SGTC_2395 5646831 3.79 180.2 µM 1.96E-4 26 7.66E-5
20 SGTC_124 0136-0217 3.77 7.1 µM 2.06E-4 mitochondrial stress 64 8.10E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.239 5.96E-45 YFL021W GAT1 hom Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
0.166 3.20E-22 YDR257C RKM4 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein
0.163 2.69E-21 YJL102W MEF2 hom Mitochondrial elongation factor involved in translational elongation
0.149 5.23E-18 YIL153W RRD1 hom Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress
0.142 1.11E-16 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.142 1.37E-16 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.142 1.64E-16 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.138 9.31E-16 YDR435C PPM1 hom Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
0.136 2.68E-15 YER040W GLN3 hom Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source
0.136 3.29E-15 YJL176C SWI3 hom Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions
0.130 4.87E-14 YDR308C SRB7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
0.128 1.15E-13 YNL199C GCR2 hom Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
0.127 1.57E-13 YDL136W RPL35B hom Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication
0.120 4.05E-12 YNL236W SIN4 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
0.115 2.46E-11 YML113W DAT1 hom DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability