YNL155W

Protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL155W / YNL155W

Click on Significant Values for Screen Details

Top fitness defect scores for YNL155W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_911 3456-4043 5.78 236.0 µM 2.25E-10 mitochondrial processes 4 3.78E-9
2 SGTC_1355 1499-0035 4.70 1.7 µM 1.96E-7 4 1.31E-6
3 SGTC_459 nigericin 4.44 15.3 µM 8.04E-7 52 4.43E-6
4 SGTC_2489 cantharidin 4.04 73.4 µM 6.53E-6 cell wall signaling 37 2.72E-5
5 SGTC_102 gallobenzophenone 4.01 83.6 µM 7.50E-6 redox potentiating 42 3.06E-5
6 SGTC_21 0849-0113 3.93 23.0 µM 1.07E-5 31 4.18E-5
7 SGTC_3016 9080866 3.78 49.5 µM 2.27E-5 30 8.00E-5
8 SGTC_2859 9028643 3.53 45.5 µM 6.87E-5 25 2.09E-4
9 SGTC_2981 9013952 3.46 39.0 µM 9.18E-5 62 2.68E-4
10 SGTC_475 α-linolenic acid 3.32 10.0 µM 1.66E-4 excess fatty acid 37 4.49E-4
11 SGTC_2358 9037157 3.21 4.0 µM 2.64E-4 61 6.71E-4
12 SGTC_1707 st032323 3.18 6.3 µM 3.00E-4 DNA damage response 96 7.49E-4
13 SGTC_24 0417-1663 3.15 219.0 µM 3.34E-4 46 8.22E-4
14 SGTC_1813 st051246 3.14 8.6 µM 3.39E-4 TSC3-RPN4 25 8.34E-4
15 SGTC_2322 7413319 3.14 38.2 µM 3.40E-4 ERAD & cell cycle 216 8.36E-4
16 SGTC_140 0062-0056 3.11 502.5 µM 3.87E-4 55 9.34E-4
17 SGTC_2856 9022925 3.06 19.5 µM 4.71E-4 66 0.00111
18 SGTC_2146 5545642 3.03 200.0 µM 5.21E-4 55 0.00121
19 SGTC_976 1348-1067 3.02 47.6 µM 5.52E-4 60S ribosome export 78 0.00127
20 SGTC_2254 7938975 2.90 95.2 µM 8.66E-4 110 0.00188

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.94E-15 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.117 1.28E-11 YBR235W VHC1 hom Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family
0.112 8.28E-11 YBR151W APD1 hom Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus
0.106 8.09E-10 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.094 5.13E-8 YGL113W SLD3 het Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress
0.091 1.26E-7 YHL040C ARN1 hom ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress
0.086 5.54E-7 YNL243W SLA2 hom Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo
0.082 2.10E-6 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.080 3.08E-6 YML043C RRN11 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.080 3.96E-6 YOL151W GRE2 hom 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.079 4.63E-6 YIL085C KTR7 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication
0.079 4.97E-6 YHR057C CPR2 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway
0.077 7.41E-6 YBR107C IML3 hom Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1
0.077 9.15E-6 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.076 9.46E-6 YBR001C NTH2 hom Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication