YNL157W / IGO1

Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL157W / IGO1

Click on Significant Values for Screen Details ID:SGTC_173|Compound:1273-0061|FD-Score:-3.07|P-value:1.67E-4 ID:SGTC_251|Compound:melphalan|FD-Score:2.94|P-value:1.78E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:2.66|P-value:5.95E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:2.55|P-value:9.19E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.41|P-value:3.40E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:7.18|P-value:3.22E-18 ID:SGTC_1414|Compound:3917-0015|FD-Score:2.77|P-value:3.71E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.14|P-value:1.25E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.51|P-value:2.00E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-2.68|P-value:9.17E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.72|P-value:6.73E-6 ID:SGTC_1682|Compound:st012968|FD-Score:-3.20|P-value:9.44E-5 ID:SGTC_1740|Compound:st038286|FD-Score:2.88|P-value:2.27E-4 ID:SGTC_1749|Compound:st037932|FD-Score:2.92|P-value:1.93E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:2.82|P-value:2.95E-4 ID:SGTC_1923|Compound:st058458|FD-Score:2.69|P-value:5.26E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-2.74|P-value:7.09E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.36|P-value:4.35E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.29|P-value:6.11E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.49|P-value:1.20E-5 ID:SGTC_2143|Compound:5623677|FD-Score:2.58|P-value:8.38E-4 ID:SGTC_2198|Compound:6589944|FD-Score:3.32|P-value:2.78E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.22|P-value:4.70E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.18|P-value:5.64E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.26|P-value:6.89E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-2.97|P-value:2.61E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:2.66|P-value:6.07E-4 ID:SGTC_2678|Compound:equilin|FD-Score:2.88|P-value:2.32E-4 ID:SGTC_2859|Compound:9028643|FD-Score:2.76|P-value:3.88E-4 ID:SGTC_2970|Compound:9090938|FD-Score:2.54|P-value:9.83E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.17|P-value:1.06E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.12|P-value:7.69E-5 ID:SGTC_3252|Compound:9135871|FD-Score:2.58|P-value:8.36E-4 ID:SGTC_3328|Compound:9140624|FD-Score:2.71|P-value:4.93E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.07|P-value:1.67E-4 ID:SGTC_251|Compound:melphalan|FD-Score:2.94|P-value:1.78E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:2.66|P-value:5.95E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:2.55|P-value:9.19E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.41|P-value:3.40E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:7.18|P-value:3.22E-18 ID:SGTC_1414|Compound:3917-0015|FD-Score:2.77|P-value:3.71E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.14|P-value:1.25E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.51|P-value:2.00E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-2.68|P-value:9.17E-4 ID:SGTC_1673|Compound:st016611|FD-Score:-3.72|P-value:6.73E-6 ID:SGTC_1682|Compound:st012968|FD-Score:-3.20|P-value:9.44E-5 ID:SGTC_1740|Compound:st038286|FD-Score:2.88|P-value:2.27E-4 ID:SGTC_1749|Compound:st037932|FD-Score:2.92|P-value:1.93E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:2.82|P-value:2.95E-4 ID:SGTC_1923|Compound:st058458|FD-Score:2.69|P-value:5.26E-4 ID:SGTC_1962|Compound:st076595|FD-Score:-2.74|P-value:7.09E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.36|P-value:4.35E-5 ID:SGTC_2024|Compound:5144227|FD-Score:-3.29|P-value:6.11E-5 ID:SGTC_2114|Compound:5491910|FD-Score:3.49|P-value:1.20E-5 ID:SGTC_2143|Compound:5623677|FD-Score:2.58|P-value:8.38E-4 ID:SGTC_2198|Compound:6589944|FD-Score:3.32|P-value:2.78E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.22|P-value:4.70E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.18|P-value:5.64E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.26|P-value:6.89E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-2.97|P-value:2.61E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:2.66|P-value:6.07E-4 ID:SGTC_2678|Compound:equilin|FD-Score:2.88|P-value:2.32E-4 ID:SGTC_2859|Compound:9028643|FD-Score:2.76|P-value:3.88E-4 ID:SGTC_2970|Compound:9090938|FD-Score:2.54|P-value:9.83E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-3.17|P-value:1.06E-4 ID:SGTC_3133|Compound:9127736|FD-Score:3.12|P-value:7.69E-5 ID:SGTC_3252|Compound:9135871|FD-Score:2.58|P-value:8.36E-4 ID:SGTC_3328|Compound:9140624|FD-Score:2.71|P-value:4.93E-4

Top fitness defect scores for YNL157W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1230 0170-0365 7.18 3.8 µM 3.22E-18 endomembrane recycling 12 3.47E-13
2 SGTC_2114 5491910 3.49 81.2 µM 1.20E-5 25 2.45E-4
3 SGTC_2198 6589944 3.32 200.0 µM 2.78E-5 27 4.45E-4
4 SGTC_2412 st077135 3.22 33.4 µM 4.70E-5 52 6.45E-4
5 SGTC_2581 avocatin a 3.18 64.0 µM 5.64E-5 sphingolipid biosynthesis & PDR1 85 7.34E-4
6 SGTC_3133 9127736 3.12 49.5 µM 7.69E-5 49 9.14E-4
7 SGTC_251 melphalan 2.94 456.5 µM 1.78E-4 DNA damage response 82 0.00166
8 SGTC_1749 st037932 2.92 54.2 µM 1.93E-4 83 0.00176
9 SGTC_1740 st038286 2.88 13.2 µM 2.27E-4 89 0.00197
10 SGTC_2678 equilin 2.88 100.0 µM 2.32E-4 68 0.00200
11 SGTC_1844 rapamycin 2.82 4.0 nM 2.95E-4 260 0.00237
12 SGTC_1414 3917-0015 2.77 5.4 µM 3.71E-4 57 0.00279
13 SGTC_2859 9028643 2.76 45.5 µM 3.88E-4 59 0.00288
14 SGTC_3328 9140624 2.71 29.0 µM 4.93E-4 84 0.00341
15 SGTC_1923 st058458 2.69 19.1 µM 5.26E-4 121 0.00357
16 SGTC_391 gliotoxin 2.66 8.3 µM 5.95E-4 133 0.00390
17 SGTC_2667 digitoxin 2.66 100.0 µM 6.07E-4 40 0.00396
18 SGTC_3252 9135871 2.58 49.5 µM 8.36E-4 82 0.00497
19 SGTC_2143 5623677 2.58 140.5 µM 8.38E-4 50 0.00498
20 SGTC_1207 2099-0101 2.55 141.0 µM 9.19E-4 108 0.00532

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.280 1.42E-61 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.193 2.30E-29 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.184 5.69E-27 YNL209W SSB2 hom Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication
0.184 5.68E-27 YDR006C SOK1 hom Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
0.173 4.55E-24 YDL128W VCX1 hom Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
0.173 5.83E-24 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.161 6.99E-21 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.149 3.55E-18 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.147 9.65E-18 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.141 2.63E-16 YDR274C_d YDR274C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136 2.22E-15 YHR001W OSH7 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.130 4.99E-14 YHR071W PCL5 hom Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
0.127 1.36E-13 YKR061W KTR2 hom Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication
0.124 6.75E-13 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.123 9.41E-13 YKL128C PMU1 hom Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant