YNL162W-A_p

Putative protein of unknown function; identified by homology

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL162W-A / YNL162W-A

Click on Significant Values for Screen Details ID:SGTC_162|Compound:k030-0015|FD-Score:3.94|P-value:2.03E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.26|P-value:3.58E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.34|P-value:2.50E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.68|P-value:6.35E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:3.43|P-value:1.79E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.11|P-value:6.14E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.28|P-value:3.32E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-3.98|P-value:1.78E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.09|P-value:6.56E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:4.83|P-value:2.49E-7 ID:SGTC_894|Compound:0960-0238|FD-Score:4.17|P-value:6.94E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.05|P-value:7.79E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.56|P-value:1.05E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.50|P-value:1.34E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.02|P-value:8.42E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.33|P-value:2.67E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.93|P-value:2.10E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.50|P-value:1.39E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:2.98|P-value:9.40E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.95|P-value:2.06E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.91|P-value:2.38E-5 ID:SGTC_1647|Compound:st011722|FD-Score:3.08|P-value:6.62E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.53|P-value:1.18E-6 ID:SGTC_1772|Compound:st048439|FD-Score:-3.01|P-value:8.97E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.42|P-value:1.92E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.14|P-value:5.31E-4 ID:SGTC_2125|Compound:5246583|FD-Score:9.43|P-value:5.08E-23 ID:SGTC_2349|Compound:9023730|FD-Score:5.49|P-value:5.69E-9 ID:SGTC_2351|Compound:9026858|FD-Score:-5.36|P-value:1.28E-8 ID:SGTC_2372|Compound:9071633|FD-Score:4.47|P-value:1.63E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.01|P-value:8.58E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-4.95|P-value:1.36E-7 ID:SGTC_2438|Compound:5259590|FD-Score:2.99|P-value:9.27E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.71|P-value:4.79E-7 ID:SGTC_2463|Compound:5473429|FD-Score:-3.05|P-value:7.61E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.31|P-value:2.79E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.14|P-value:5.34E-4 ID:SGTC_2487|Compound:5918373|FD-Score:4.33|P-value:3.23E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:5.43|P-value:7.96E-9 ID:SGTC_2570|Compound:licareol|FD-Score:-3.17|P-value:4.93E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-4.89|P-value:1.86E-7 ID:SGTC_2576|Compound:guaiol|FD-Score:-4.88|P-value:2.04E-7 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.65|P-value:7.27E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.93|P-value:2.18E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-4.88|P-value:2.00E-7 ID:SGTC_2844|Compound:9010103|FD-Score:3.24|P-value:3.77E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.48|P-value:1.43E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.13|P-value:8.48E-6 ID:SGTC_2963|Compound:9082507|FD-Score:3.91|P-value:2.35E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.03|P-value:8.05E-4 ID:SGTC_3014|Compound:9081533|FD-Score:4.48|P-value:1.57E-6 ID:SGTC_3062|Compound:9077494|FD-Score:3.25|P-value:3.52E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.65|P-value:7.29E-5 ID:SGTC_3184|Compound:9108758|FD-Score:3.09|P-value:6.44E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.07|P-value:7.25E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.28|P-value:3.32E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.20|P-value:4.29E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.43|P-value:1.80E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.27|P-value:3.50E-4 ID:SGTC_162|Compound:k030-0015|FD-Score:3.94|P-value:2.03E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.26|P-value:3.58E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.34|P-value:2.50E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:3.68|P-value:6.35E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:3.43|P-value:1.79E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.11|P-value:6.14E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.28|P-value:3.32E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-3.98|P-value:1.78E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.09|P-value:6.56E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:4.83|P-value:2.49E-7 ID:SGTC_894|Compound:0960-0238|FD-Score:4.17|P-value:6.94E-6 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.05|P-value:7.79E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.56|P-value:1.05E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.50|P-value:1.34E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.02|P-value:8.42E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.33|P-value:2.67E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:3.93|P-value:2.10E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.50|P-value:1.39E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:2.98|P-value:9.40E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-3.95|P-value:2.06E-5 ID:SGTC_1635|Compound:st007035|FD-Score:3.91|P-value:2.38E-5 ID:SGTC_1647|Compound:st011722|FD-Score:3.08|P-value:6.62E-4 ID:SGTC_1727|Compound:st034309|FD-Score:4.53|P-value:1.18E-6 ID:SGTC_1772|Compound:st048439|FD-Score:-3.01|P-value:8.97E-4 ID:SGTC_1834|Compound:st055981|FD-Score:-3.42|P-value:1.92E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.14|P-value:5.31E-4 ID:SGTC_2125|Compound:5246583|FD-Score:9.43|P-value:5.08E-23 ID:SGTC_2349|Compound:9023730|FD-Score:5.49|P-value:5.69E-9 ID:SGTC_2351|Compound:9026858|FD-Score:-5.36|P-value:1.28E-8 ID:SGTC_2372|Compound:9071633|FD-Score:4.47|P-value:1.63E-6 ID:SGTC_2415|Compound:st077333|FD-Score:3.01|P-value:8.58E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-4.95|P-value:1.36E-7 ID:SGTC_2438|Compound:5259590|FD-Score:2.99|P-value:9.27E-4 ID:SGTC_2451|Compound:5856223|FD-Score:4.71|P-value:4.79E-7 ID:SGTC_2463|Compound:5473429|FD-Score:-3.05|P-value:7.61E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.31|P-value:2.79E-4 ID:SGTC_2483|Compound:5729050|FD-Score:3.14|P-value:5.34E-4 ID:SGTC_2487|Compound:5918373|FD-Score:4.33|P-value:3.23E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:5.43|P-value:7.96E-9 ID:SGTC_2570|Compound:licareol|FD-Score:-3.17|P-value:4.93E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-4.89|P-value:1.86E-7 ID:SGTC_2576|Compound:guaiol|FD-Score:-4.88|P-value:2.04E-7 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.65|P-value:7.27E-5 ID:SGTC_2754|Compound:granisetron|FD-Score:3.93|P-value:2.18E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-4.88|P-value:2.00E-7 ID:SGTC_2844|Compound:9010103|FD-Score:3.24|P-value:3.77E-4 ID:SGTC_2877|Compound:9040724|FD-Score:3.48|P-value:1.43E-4 ID:SGTC_2878|Compound:9043973|FD-Score:4.13|P-value:8.48E-6 ID:SGTC_2963|Compound:9082507|FD-Score:3.91|P-value:2.35E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.03|P-value:8.05E-4 ID:SGTC_3014|Compound:9081533|FD-Score:4.48|P-value:1.57E-6 ID:SGTC_3062|Compound:9077494|FD-Score:3.25|P-value:3.52E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.65|P-value:7.29E-5 ID:SGTC_3184|Compound:9108758|FD-Score:3.09|P-value:6.44E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-3.07|P-value:7.25E-4 ID:SGTC_3307|Compound:9126885|FD-Score:-3.28|P-value:3.32E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.20|P-value:4.29E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.43|P-value:1.80E-4 ID:SGTC_3330|Compound:9141424|FD-Score:-3.27|P-value:3.50E-4

Top fitness defect scores for YNL162W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2125 5246583 9.43 200.0 µM 5.08E-23 tubulin folding & SWR complex 5 2.04E-21
2 SGTC_2349 9023730 5.49 187.1 µM 5.69E-9 5 2.06E-8
3 SGTC_2563 tomatine 5.43 8.5 µM 7.96E-9 17 2.81E-8
4 SGTC_882 0843-0131 4.83 351.0 µM 2.49E-7 7 6.82E-7
5 SGTC_2451 5856223 4.71 45.7 µM 4.79E-7 12 1.25E-6
6 SGTC_1727 st034309 4.53 9.9 µM 1.18E-6 20 2.90E-6
7 SGTC_3014 9081533 4.48 49.5 µM 1.57E-6 6 3.75E-6
8 SGTC_2372 9071633 4.47 200.0 µM 1.63E-6 7 3.89E-6
9 SGTC_2487 5918373 4.33 44.0 µM 3.23E-6 8 7.34E-6
10 SGTC_894 0960-0238 4.17 55.9 µM 6.94E-6 6 1.49E-5
11 SGTC_2878 9043973 4.13 26.0 µM 8.48E-6 17 1.80E-5
12 SGTC_162 k030-0015 3.94 37.8 µM 2.03E-5 iron homeostasis 22 4.04E-5
13 SGTC_1447 4239-0816 3.93 81.9 µM 2.10E-5 28 4.16E-5
14 SGTC_2754 granisetron 3.93 64.0 µM 2.18E-5 30 4.31E-5
15 SGTC_2963 9082507 3.91 9.0 µM 2.35E-5 26 4.63E-5
16 SGTC_1635 st007035 3.91 42.4 µM 2.38E-5 212 4.68E-5
17 SGTC_430 0958-0115 3.68 16.4 µM 6.35E-5 32 1.16E-4
18 SGTC_2578 7,8-dihydroxyflavone 3.65 64.4 µM 7.27E-5 38 1.32E-4
19 SGTC_3131 9127911 3.65 49.5 µM 7.29E-5 41 1.32E-4
20 SGTC_1119 parthenolide 3.56 318.5 nM 1.05E-4 TSC3-RPN4 54 1.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 2.13E-25 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.159 2.84E-20 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.158 4.65E-20 YOL078W AVO1 het Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.156 9.59E-20 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.150 2.29E-18 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.146 2.40E-17 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.146 2.30E-17 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.145 3.82E-17 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.144 4.14E-17 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.144 6.61E-17 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.143 8.02E-17 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.136 2.63E-15 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.133 9.79E-15 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.133 1.04E-14 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.133 1.27E-14 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs