| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|
| 0.178 |
2.13E-25 |
YKL066W_d |
YKL066W_d |
hom |
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1 |
| 0.159 |
2.84E-20 |
YJR120W |
YJR120W |
hom |
Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p |
| 0.158 |
4.65E-20 |
YOL078W |
AVO1 |
het |
Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth |
| 0.156 |
9.59E-20 |
YDL222C |
FMP45 |
hom |
Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C |
| 0.150 |
2.29E-18 |
YHR050W-A_p |
YHR050W-A_p |
hom |
Protein of unknown function; identified by expression profiling and mass spectrometry |
| 0.146 |
2.40E-17 |
YGR183C |
QCR9 |
hom |
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex |
| 0.146 |
2.30E-17 |
YLR038C |
COX12 |
hom |
Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV |
| 0.145 |
3.82E-17 |
YPL215W |
CBP3 |
hom |
Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex |
| 0.144 |
4.14E-17 |
YJL166W |
QCR8 |
hom |
Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p |
| 0.144 |
6.61E-17 |
YER141W |
COX15 |
hom |
Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase |
| 0.143 |
8.02E-17 |
YMR151W_d |
YIM2_d |
hom |
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 |
| 0.136 |
2.63E-15 |
YEL059C-A |
SOM1 |
hom |
Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs |
| 0.133 |
9.79E-15 |
YPL013C |
MRPS16 |
hom |
Mitochondrial ribosomal protein of the small subunit |
| 0.133 |
1.04E-14 |
YDR375C |
BCS1 |
hom |
Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases |
| 0.133 |
1.27E-14 |
YLL009C |
COX17 |
hom |
Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs |
