YNL166C / BNI5

Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL166C / BNI5

Click on Significant Values for Screen Details ID:SGTC_228|Compound:caffeine|FD-Score:2.93|P-value:3.73E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.82|P-value:4.89E-6 ID:SGTC_327|Compound:1273-0057|FD-Score:2.80|P-value:6.27E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.01|P-value:2.39E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.47|P-value:2.96E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:3.25|P-value:8.93E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.85|P-value:4.72E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.02|P-value:2.46E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-5.32|P-value:3.79E-10 ID:SGTC_1131|Compound:3454-3128|FD-Score:6.89|P-value:9.53E-16 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.31|P-value:6.69E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:2.96|P-value:3.22E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.45|P-value:3.27E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:-4.13|P-value:8.85E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-10.80|P-value:3.16E-36 ID:SGTC_1463|Compound:k081-0032|FD-Score:-10.10|P-value:1.28E-31 ID:SGTC_1980|Compound:st071811|FD-Score:-2.98|P-value:2.80E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.16|P-value:7.86E-7 ID:SGTC_2258|Compound:7960471|FD-Score:-2.68|P-value:9.43E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.23|P-value:1.00E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.43|P-value:3.92E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.06|P-value:1.33E-12 ID:SGTC_2799|Compound:7812892|FD-Score:3.84|P-value:4.83E-6 ID:SGTC_2830|Compound:7992007|FD-Score:2.95|P-value:3.43E-4 ID:SGTC_2835|Compound:9006588|FD-Score:2.83|P-value:5.56E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-2.73|P-value:7.76E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.21|P-value:1.01E-4 ID:SGTC_2987|Compound:9018338|FD-Score:2.86|P-value:4.90E-4 ID:SGTC_3022|Compound:9087993|FD-Score:2.69|P-value:9.61E-4 ID:SGTC_3037|Compound:9091026|FD-Score:2.80|P-value:6.19E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.11|P-value:1.61E-4 ID:SGTC_3085|Compound:9117376|FD-Score:2.96|P-value:3.19E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.75|P-value:6.94E-6 ID:SGTC_3102|Compound:9121669|FD-Score:3.20|P-value:1.14E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-2.76|P-value:6.91E-4 ID:SGTC_3169|Compound:9102970|FD-Score:2.90|P-value:4.17E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-2.78|P-value:6.27E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.34|P-value:5.97E-5 ID:SGTC_228|Compound:caffeine|FD-Score:2.93|P-value:3.73E-4 ID:SGTC_233|Compound:rapamycin|FD-Score:-3.82|P-value:4.89E-6 ID:SGTC_327|Compound:1273-0057|FD-Score:2.80|P-value:6.27E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.01|P-value:2.39E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.47|P-value:2.96E-5 ID:SGTC_603|Compound:3794-0023|FD-Score:3.25|P-value:8.93E-5 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.85|P-value:4.72E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.02|P-value:2.46E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-5.32|P-value:3.79E-10 ID:SGTC_1131|Compound:3454-3128|FD-Score:6.89|P-value:9.53E-16 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.31|P-value:6.69E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:2.96|P-value:3.22E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-3.45|P-value:3.27E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:-4.13|P-value:8.85E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-10.80|P-value:3.16E-36 ID:SGTC_1463|Compound:k081-0032|FD-Score:-10.10|P-value:1.28E-31 ID:SGTC_1980|Compound:st071811|FD-Score:-2.98|P-value:2.80E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.16|P-value:7.86E-7 ID:SGTC_2258|Compound:7960471|FD-Score:-2.68|P-value:9.43E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.23|P-value:1.00E-4 ID:SGTC_2348|Compound:9022543|FD-Score:3.43|P-value:3.92E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.06|P-value:1.33E-12 ID:SGTC_2799|Compound:7812892|FD-Score:3.84|P-value:4.83E-6 ID:SGTC_2830|Compound:7992007|FD-Score:2.95|P-value:3.43E-4 ID:SGTC_2835|Compound:9006588|FD-Score:2.83|P-value:5.56E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-2.73|P-value:7.76E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.21|P-value:1.01E-4 ID:SGTC_2987|Compound:9018338|FD-Score:2.86|P-value:4.90E-4 ID:SGTC_3022|Compound:9087993|FD-Score:2.69|P-value:9.61E-4 ID:SGTC_3037|Compound:9091026|FD-Score:2.80|P-value:6.19E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.11|P-value:1.61E-4 ID:SGTC_3085|Compound:9117376|FD-Score:2.96|P-value:3.19E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.75|P-value:6.94E-6 ID:SGTC_3102|Compound:9121669|FD-Score:3.20|P-value:1.14E-4 ID:SGTC_3114|Compound:9122766|FD-Score:-2.76|P-value:6.91E-4 ID:SGTC_3169|Compound:9102970|FD-Score:2.90|P-value:4.17E-4 ID:SGTC_3303|Compound:9125618|FD-Score:-2.78|P-value:6.27E-4 ID:SGTC_3313|Compound:9133968|FD-Score:3.34|P-value:5.97E-5

Top fitness defect scores for YNL166C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1131 3454-3128 6.89 32.3 µM 9.53E-16 4 2.86E-12
2 SGTC_2582 agaric acid 6.06 100.0 µM 1.33E-12 redox potentiating 157 6.73E-10
3 SGTC_2111 5486399 4.16 200.0 µM 7.86E-7 39 1.56E-5
4 SGTC_2799 7812892 3.84 81.8 µM 4.83E-6 superoxide 32 6.21E-5
5 SGTC_2348 9022543 3.43 33.4 µM 3.92E-5 mitochondrial processes 46 3.06E-4
6 SGTC_3313 9133968 3.34 57.0 µM 5.97E-5 17 4.22E-4
7 SGTC_1139 k015-0024 3.31 46.9 µM 6.69E-5 PDR1 27 4.60E-4
8 SGTC_603 3794-0023 3.25 45.9 µM 8.93E-5 25 5.74E-4
9 SGTC_2282 7944268 3.23 200.0 µM 1.00E-4 RPP1 & pyrimidine depletion 70 6.27E-4
10 SGTC_3102 9121669 3.20 49.5 µM 1.14E-4 22 6.92E-4
11 SGTC_1009 4106-0057 3.02 9.9 µM 2.46E-4 41 0.00125
12 SGTC_3085 9117376 2.96 49.5 µM 3.19E-4 52 0.00152
13 SGTC_1140 3229-1848 2.96 3.0 µM 3.22E-4 33 0.00153
14 SGTC_2830 7992007 2.95 71.4 µM 3.43E-4 65 0.00161
15 SGTC_228 caffeine 2.93 993.1 µM 3.73E-4 38 0.00171
16 SGTC_3169 9102970 2.90 49.5 µM 4.17E-4 RPP1 & pyrimidine depletion 25 0.00187
17 SGTC_2987 9018338 2.86 71.4 µM 4.90E-4 RPP1 & pyrimidine depletion 86 0.00211
18 SGTC_2835 9006588 2.83 71.4 µM 5.56E-4 112 0.00233
19 SGTC_3037 9091026 2.80 49.5 µM 6.19E-4 NEO1-PIK1 235 0.00253
20 SGTC_327 1273-0057 2.80 4.0 µM 6.27E-4 azole & statin 77 0.00255

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.511 1.45E-221 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.487 6.80E-199 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.453 7.51E-168 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.433 1.33E-152 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.414 6.42E-139 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.396 6.51E-126 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.381 1.15E-115 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.380 1.62E-115 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.373 1.07E-110 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.363 1.25E-104 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.349 1.11E-96 YMR107W SPG4 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.345 5.34E-94 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.341 2.17E-91 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.340 2.33E-91 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.336 5.00E-89 YJR146W_p YJR146W_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2