YNL177C / MRPL22

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL177C / MRPL22

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.97|P-value:4.29E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.97|P-value:4.39E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.63|P-value:4.46E-16 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.78|P-value:9.20E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:17.90|P-value:2.27E-50 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.31|P-value:2.00E-12 ID:SGTC_310|Compound:1273-0058|FD-Score:9.71|P-value:2.64E-16 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.57|P-value:7.98E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.82|P-value:7.50E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.06|P-value:4.09E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.16|P-value:3.03E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:5.60|P-value:1.40E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-8.72|P-value:2.43E-13 ID:SGTC_832|Compound:4083-0019|FD-Score:5.85|P-value:5.00E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:4.31|P-value:1.49E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.43|P-value:1.01E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.60|P-value:5.81E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.73|P-value:8.83E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.66|P-value:4.65E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.10|P-value:9.80E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.06|P-value:1.15E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.64|P-value:5.12E-5 ID:SGTC_1742|Compound:st038235|FD-Score:7.16|P-value:1.10E-9 ID:SGTC_1800|Compound:st050079|FD-Score:-4.61|P-value:7.01E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-5.23|P-value:7.68E-6 ID:SGTC_1962|Compound:st076595|FD-Score:-4.49|P-value:1.03E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.18|P-value:2.25E-4 ID:SGTC_2010|Compound:4012422|FD-Score:4.60|P-value:5.85E-5 ID:SGTC_2019|Compound:4016004|FD-Score:4.08|P-value:3.14E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-6.51|P-value:3.52E-8 ID:SGTC_2036|Compound:5160441|FD-Score:-3.95|P-value:5.60E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.64|P-value:8.86E-11 ID:SGTC_2283|Compound:7944793|FD-Score:4.57|P-value:6.41E-5 ID:SGTC_2488|Compound:5268135|FD-Score:4.15|P-value:2.49E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-4.36|P-value:1.60E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.58|P-value:6.20E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-6.29|P-value:9.87E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-4.11|P-value:3.44E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.69|P-value:9.76E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.99|P-value:1.26E-11 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-4.43|P-value:1.29E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.11|P-value:2.83E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-4.78|P-value:3.97E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.73|P-value:8.77E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.47|P-value:1.10E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-12.30|P-value:8.66E-25 ID:SGTC_2778|Compound:tioconazole|FD-Score:-8.40|P-value:1.74E-12 ID:SGTC_2825|Compound:7998094|FD-Score:4.55|P-value:6.89E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-9.42|P-value:2.96E-15 ID:SGTC_2933|Compound:9026794|FD-Score:3.83|P-value:6.59E-4 ID:SGTC_2972|Compound:9093619|FD-Score:4.41|P-value:1.10E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.84|P-value:6.29E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.75|P-value:9.83E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.76|P-value:9.65E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.85|P-value:7.58E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.09|P-value:3.67E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.97|P-value:4.29E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.97|P-value:4.39E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.63|P-value:4.46E-16 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.78|P-value:9.20E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:17.90|P-value:2.27E-50 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.31|P-value:2.00E-12 ID:SGTC_310|Compound:1273-0058|FD-Score:9.71|P-value:2.64E-16 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.57|P-value:7.98E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.82|P-value:7.50E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.06|P-value:4.09E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.16|P-value:3.03E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:5.60|P-value:1.40E-6 ID:SGTC_758|Compound:0868-0029|FD-Score:-8.72|P-value:2.43E-13 ID:SGTC_832|Compound:4083-0019|FD-Score:5.85|P-value:5.00E-7 ID:SGTC_892|Compound:0929-0076|FD-Score:4.31|P-value:1.49E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.43|P-value:1.01E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.60|P-value:5.81E-5 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.73|P-value:8.83E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.66|P-value:4.65E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:5.10|P-value:9.80E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.06|P-value:1.15E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.64|P-value:5.12E-5 ID:SGTC_1742|Compound:st038235|FD-Score:7.16|P-value:1.10E-9 ID:SGTC_1800|Compound:st050079|FD-Score:-4.61|P-value:7.01E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-5.23|P-value:7.68E-6 ID:SGTC_1962|Compound:st076595|FD-Score:-4.49|P-value:1.03E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.18|P-value:2.25E-4 ID:SGTC_2010|Compound:4012422|FD-Score:4.60|P-value:5.85E-5 ID:SGTC_2019|Compound:4016004|FD-Score:4.08|P-value:3.14E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-6.51|P-value:3.52E-8 ID:SGTC_2036|Compound:5160441|FD-Score:-3.95|P-value:5.60E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.64|P-value:8.86E-11 ID:SGTC_2283|Compound:7944793|FD-Score:4.57|P-value:6.41E-5 ID:SGTC_2488|Compound:5268135|FD-Score:4.15|P-value:2.49E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:-4.36|P-value:1.60E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.58|P-value:6.20E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-6.29|P-value:9.87E-8 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-4.11|P-value:3.44E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.69|P-value:9.76E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.99|P-value:1.26E-11 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-4.43|P-value:1.29E-4 ID:SGTC_2691|Compound:st077356|FD-Score:4.11|P-value:2.83E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-4.78|P-value:3.97E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.73|P-value:8.77E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-4.47|P-value:1.10E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-12.30|P-value:8.66E-25 ID:SGTC_2778|Compound:tioconazole|FD-Score:-8.40|P-value:1.74E-12 ID:SGTC_2825|Compound:7998094|FD-Score:4.55|P-value:6.89E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-9.42|P-value:2.96E-15 ID:SGTC_2933|Compound:9026794|FD-Score:3.83|P-value:6.59E-4 ID:SGTC_2972|Compound:9093619|FD-Score:4.41|P-value:1.10E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.84|P-value:6.29E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.75|P-value:9.83E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.76|P-value:9.65E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-3.85|P-value:7.58E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.09|P-value:3.67E-4

Top fitness defect scores for YNL177C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 17.90 5.3 µM 2.27E-50 72 1.42E-71
2 SGTC_310 1273-0058 9.71 1.1 µM 2.64E-16 mitochondrial stress 45 1.39E-22
3 SGTC_173 1273-0061 9.63 2.7 µM 4.46E-16 mitochondrial stress 42 2.94E-22
4 SGTC_275 trichlorophene 8.31 5.7 µM 2.00E-12 mitochondrial stress 70 4.98E-17
5 SGTC_2688 kanamycin b 7.99 96.7 µM 1.26E-11 calcium & mitochondrial duress 64 6.98E-16
6 SGTC_2250 alverine citrate 7.64 130.0 µM 8.86E-11 25 1.13E-14
7 SGTC_1742 st038235 7.16 28.9 µM 1.10E-9 mitochondrial stress 26 4.10E-13
8 SGTC_832 4083-0019 5.85 164.0 µM 5.00E-7 translation 22 2.51E-9
9 SGTC_727 3032-0951 5.60 202.0 µM 1.40E-6 11 1.09E-8
10 SGTC_1319 1306-0155 5.10 43.7 µM 9.80E-6 7 1.72E-7
11 SGTC_1371 2421-0008 5.06 32.7 µM 1.15E-5 mitochondrial processes 12 2.14E-7
12 SGTC_1318 1280-3875 4.66 124.0 µM 4.65E-5 16 1.55E-6
13 SGTC_1627 st003713 4.64 25.6 µM 5.12E-5 calcium & mitochondrial duress 51 1.78E-6
14 SGTC_1119 parthenolide 4.60 318.5 nM 5.81E-5 TSC3-RPN4 26 2.13E-6
15 SGTC_2010 4012422 4.60 159.0 µM 5.85E-5 8 2.14E-6
16 SGTC_2526 patulin 4.58 37.6 µM 6.20E-5 58 2.33E-6
17 SGTC_2283 7944793 4.57 200.0 µM 6.41E-5 24 2.44E-6
18 SGTC_2825 7998094 4.55 58.4 µM 6.89E-5 fatty acid desaturase (OLE1) 20 2.70E-6
19 SGTC_908 3448-7491 4.43 47.7 µM 1.01E-4 mitochondrial stress 95 4.62E-6
20 SGTC_2972 9093619 4.41 59.9 µM 1.10E-4 11 5.20E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.514 8.89E-226 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.511 8.82E-222 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.510 5.96E-222 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.508 2.00E-219 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.490 1.43E-201 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.479 5.27E-192 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.479 3.07E-191 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.477 9.18E-190 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.472 3.51E-186 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.470 2.13E-184 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.467 1.75E-181 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.465 1.25E-179 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.463 1.14E-177 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.462 1.91E-177 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.459 2.05E-174 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation