HIPHOP chemogenomics database

YNL181W_p

Putative oxidoreductase; required for cell viability

Zygosity: Heterozygous strain

fixedexpanded
Profile for YNL181W / YNL181W

Click on Significant Values for Screen Details

Top fitness defect scores for YNL181W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2629	bisabolol	8.46	100.0 µM	9.88E-25		1	1.35E-17	1.34
2	SGTC_1783	st039459	6.23	87.5 µM	2.90E-14	Golgi	2	2.30E-10	0.91
3	SGTC_884	0851-0618	4.97	334.0 µM	1.07E-9		2	3.39E-7	0.66
4	SGTC_367	0335-0881	4.83	7.1 µM	2.93E-9	ubiquinone biosynthesis & proteasome	13	6.81E-7	0.10
5	SGTC_2764	methyldopa	4.49	94.7 µM	3.09E-8		1	3.51E-6	0.34
6	SGTC_360	0957-0399	4.18	1.0 µM	2.35E-7	cell wall	11	1.44E-5	0.14
7	SGTC_1379	2144-0755	3.92	36.5 µM	1.18E-6		5	4.45E-5	0.17
8	SGTC_1246	0422-0085	3.78	105.0 µM	2.65E-6		11	7.86E-5	0.18
9	SGTC_1787	fluconazole	3.54	80.0 µM	1.02E-5	iron homeostasis	14	2.01E-4	0.12
10	SGTC_55	0767-0285	3.43	6.6 µM	1.80E-5		11	3.00E-4	0.13
11	SGTC_1368	1852-0141	3.37	284.0 µM	2.48E-5	ERG2	8	3.76E-4	0.08
12	SGTC_1882	5615643	3.31	20.0 µM	3.45E-5	TRP & mitochondrial translation	9	4.74E-4	0.06
13	SGTC_1213	1315-0166	3.26	115.0 µM	4.24E-5		26	5.48E-4	0.05
14	SGTC_2884	9058502	3.12	52.0 µM	8.78E-5		9	9.15E-4	0.08
15	SGTC_2630	antimycin a	3.06	100.0 µM	1.13E-4	mitochondrial processes	18	0.00109	0.05
16	SGTC_642	0335-0876	3.04	158.0 µM	1.26E-4	ubiquinone biosynthesis & proteasome	21	0.00118	0.10
17	SGTC_1917	st066507	2.96	28.5 µM	1.80E-4	Golgi	25	0.00152	0.01
18	SGTC_192	3455-0609	2.92	60.9 µM	2.18E-4		15	0.00174	0.02
19	SGTC_1191	1487-1166	2.90	10.6 µM	2.44E-4	azole & statin	12	0.00188	0.01
20	SGTC_2814	7977482	2.89	43.0 µM	2.50E-4		26	0.00191	0.02

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.159	1.77E-20	YER023W	PRO3	het	Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.143	8.85E-17	YDR460W	TFB3	het	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
0.129	5.39E-14	YAL045C_d	YAL045C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A
0.129	8.00E-14	YMR178W	YMR178W	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress
0.126	2.47E-13	YHL028W	WSC4	hom	ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
0.121	1.90E-12	YLR164W	SHH4	hom	Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
0.112	6.99E-11	YGR117C_p	YGR117C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.110	1.69E-10	YCR023C	YCR023C	hom	Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
0.106	6.71E-10	YMR127C	SAS2	hom	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.106	7.01E-10	YIR028W	DAL4	hom	Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.102	3.25E-9	YOR078W	BUD21	hom	Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.101	4.91E-9	YMR285C	NGL2	hom	Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication
0.099	9.81E-9	YBR024W	SCO2	hom	Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication
0.098	1.24E-8	YJL138C	TIF2	hom	Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication
0.097	1.86E-8	YCR020C	PET18	hom	Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin