YNL184C_p

Protein of unknown function; expressed at both mRNA and protein levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL184C / YNL184C

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.76|P-value:1.24E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:9.05|P-value:7.05E-16 ID:SGTC_63|Compound:0099-0242|FD-Score:4.88|P-value:7.78E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.63|P-value:6.44E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.67|P-value:5.62E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.91|P-value:1.10E-18 ID:SGTC_195|Compound:4234-0266|FD-Score:4.31|P-value:6.78E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.67|P-value:5.68E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:23.90|P-value:1.19E-98 ID:SGTC_252|Compound:miconazole|FD-Score:-3.92|P-value:3.09E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.70|P-value:2.72E-21 ID:SGTC_283|Compound:0987-0079|FD-Score:4.53|P-value:2.99E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:9.29|P-value:1.20E-16 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.46|P-value:4.90E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:3.85|P-value:3.21E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.16|P-value:1.15E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.54|P-value:6.26E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:5.00|P-value:4.87E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.37|P-value:6.71E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-4.99|P-value:6.40E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.79|P-value:1.43E-5 ID:SGTC_500|Compound:h-89|FD-Score:-3.69|P-value:6.51E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.12|P-value:1.64E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.56|P-value:7.80E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.53|P-value:8.64E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:4.09|P-value:1.46E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.94|P-value:2.95E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.12|P-value:1.32E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.63|P-value:6.30E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:4.10|P-value:1.41E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.99|P-value:5.01E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:4.20|P-value:9.93E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.91|P-value:2.66E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:5.11|P-value:3.05E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:5.12|P-value:2.98E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:7.99|P-value:8.41E-13 ID:SGTC_969|Compound:1313-0238|FD-Score:4.23|P-value:8.98E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.75|P-value:5.31E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.63|P-value:2.67E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.94|P-value:2.40E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.54|P-value:8.28E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.81|P-value:1.03E-5 ID:SGTC_1623|Compound:st003709|FD-Score:6.42|P-value:7.10E-9 ID:SGTC_1635|Compound:st007035|FD-Score:3.61|P-value:6.89E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.37|P-value:5.31E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.89|P-value:2.78E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.80|P-value:4.63E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.86|P-value:8.32E-6 ID:SGTC_1773|Compound:st048542|FD-Score:-3.79|P-value:4.72E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.12|P-value:3.82E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.85|P-value:1.56E-7 ID:SGTC_1818|Compound:st052136|FD-Score:-3.73|P-value:5.77E-4 ID:SGTC_1882|Compound:5615643|FD-Score:4.30|P-value:6.97E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:6.92|P-value:4.86E-10 ID:SGTC_1921|Compound:5740136|FD-Score:4.42|P-value:4.50E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-3.66|P-value:7.12E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.95|P-value:2.83E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-4.13|P-value:1.56E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.63|P-value:2.06E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.56|P-value:7.95E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.56|P-value:7.99E-4 ID:SGTC_2352|Compound:9027995|FD-Score:5.00|P-value:4.75E-6 ID:SGTC_2399|Compound:5884133|FD-Score:-4.31|P-value:8.37E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.72|P-value:4.89E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.63|P-value:6.40E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.58|P-value:7.47E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-6.53|P-value:5.49E-9 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.35|P-value:7.41E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.06|P-value:1.59E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.55|P-value:1.70E-17 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-6.90|P-value:7.85E-10 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.89|P-value:3.50E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.22|P-value:2.48E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.62|P-value:2.69E-5 ID:SGTC_2887|Compound:9044784|FD-Score:-4.44|P-value:5.22E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-7.85|P-value:3.07E-12 ID:SGTC_2921|Compound:7974240|FD-Score:4.40|P-value:4.82E-5 ID:SGTC_2926|Compound:9010726|FD-Score:4.57|P-value:2.62E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.80|P-value:1.39E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-5.22|P-value:2.56E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-5.01|P-value:5.93E-6 ID:SGTC_3154|Compound:9100113|FD-Score:4.49|P-value:3.52E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-3.55|P-value:9.97E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.56|P-value:9.48E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.76|P-value:1.24E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:9.05|P-value:7.05E-16 ID:SGTC_63|Compound:0099-0242|FD-Score:4.88|P-value:7.78E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:3.63|P-value:6.44E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.67|P-value:5.62E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:9.91|P-value:1.10E-18 ID:SGTC_195|Compound:4234-0266|FD-Score:4.31|P-value:6.78E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:3.67|P-value:5.68E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:23.90|P-value:1.19E-98 ID:SGTC_252|Compound:miconazole|FD-Score:-3.92|P-value:3.09E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:10.70|P-value:2.72E-21 ID:SGTC_283|Compound:0987-0079|FD-Score:4.53|P-value:2.99E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:9.29|P-value:1.20E-16 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.46|P-value:4.90E-5 ID:SGTC_355|Compound:1311-2252|FD-Score:3.85|P-value:3.21E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:4.16|P-value:1.15E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.54|P-value:6.26E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:5.00|P-value:4.87E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.37|P-value:6.71E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-4.99|P-value:6.40E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.79|P-value:1.43E-5 ID:SGTC_500|Compound:h-89|FD-Score:-3.69|P-value:6.51E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-4.12|P-value:1.64E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.56|P-value:7.80E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.53|P-value:8.64E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:4.09|P-value:1.46E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.94|P-value:2.95E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.12|P-value:1.32E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:3.63|P-value:6.30E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:4.10|P-value:1.41E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:4.99|P-value:5.01E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:4.20|P-value:9.93E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.91|P-value:2.66E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:5.11|P-value:3.05E-6 ID:SGTC_903|Compound:1134-0042|FD-Score:5.12|P-value:2.98E-6 ID:SGTC_908|Compound:3448-7491|FD-Score:7.99|P-value:8.41E-13 ID:SGTC_969|Compound:1313-0238|FD-Score:4.23|P-value:8.98E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.75|P-value:5.31E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-4.63|P-value:2.67E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.94|P-value:2.40E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.54|P-value:8.28E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.81|P-value:1.03E-5 ID:SGTC_1623|Compound:st003709|FD-Score:6.42|P-value:7.10E-9 ID:SGTC_1635|Compound:st007035|FD-Score:3.61|P-value:6.89E-4 ID:SGTC_1675|Compound:st018485|FD-Score:4.37|P-value:5.31E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.89|P-value:2.78E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.80|P-value:4.63E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.86|P-value:8.32E-6 ID:SGTC_1773|Compound:st048542|FD-Score:-3.79|P-value:4.72E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-5.12|P-value:3.82E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.85|P-value:1.56E-7 ID:SGTC_1818|Compound:st052136|FD-Score:-3.73|P-value:5.77E-4 ID:SGTC_1882|Compound:5615643|FD-Score:4.30|P-value:6.97E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:6.92|P-value:4.86E-10 ID:SGTC_1921|Compound:5740136|FD-Score:4.42|P-value:4.50E-5 ID:SGTC_1939|Compound:st074455|FD-Score:-3.66|P-value:7.12E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-3.95|P-value:2.83E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-4.13|P-value:1.56E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.63|P-value:2.06E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.56|P-value:7.95E-4 ID:SGTC_2267|Compound:7931562|FD-Score:3.56|P-value:7.99E-4 ID:SGTC_2352|Compound:9027995|FD-Score:5.00|P-value:4.75E-6 ID:SGTC_2399|Compound:5884133|FD-Score:-4.31|P-value:8.37E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.72|P-value:4.89E-4 ID:SGTC_2526|Compound:patulin|FD-Score:3.63|P-value:6.40E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.58|P-value:7.47E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:-6.53|P-value:5.49E-9 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.35|P-value:7.41E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.06|P-value:1.59E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.55|P-value:1.70E-17 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-6.90|P-value:7.85E-10 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.89|P-value:3.50E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.22|P-value:2.48E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.62|P-value:2.69E-5 ID:SGTC_2887|Compound:9044784|FD-Score:-4.44|P-value:5.22E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-7.85|P-value:3.07E-12 ID:SGTC_2921|Compound:7974240|FD-Score:4.40|P-value:4.82E-5 ID:SGTC_2926|Compound:9010726|FD-Score:4.57|P-value:2.62E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.80|P-value:1.39E-5 ID:SGTC_3078|Compound:9116413|FD-Score:-5.22|P-value:2.56E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-5.01|P-value:5.93E-6 ID:SGTC_3154|Compound:9100113|FD-Score:4.49|P-value:3.52E-5 ID:SGTC_3264|Compound:9137442|FD-Score:-3.55|P-value:9.97E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.56|P-value:9.48E-4

Top fitness defect scores for YNL184C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 23.90 5.3 µM 1.19E-98 37 1.62E-126
2 SGTC_275 trichlorophene 10.70 5.7 µM 2.72E-21 mitochondrial stress 37 8.23E-27
3 SGTC_173 1273-0061 9.91 2.7 µM 1.10E-18 mitochondrial stress 40 1.85E-23
4 SGTC_2582 agaric acid 9.55 100.0 µM 1.70E-17 redox potentiating 76 6.21E-22
5 SGTC_310 1273-0058 9.29 1.1 µM 1.20E-16 mitochondrial stress 56 7.69E-21
6 SGTC_58 0957-0393 9.05 9.0 µM 7.05E-16 cell wall 95 7.44E-20
7 SGTC_908 3448-7491 7.99 47.7 µM 8.41E-13 mitochondrial stress 17 6.59E-16
8 SGTC_1883 5-benzylidenerhodanine 6.92 20.0 µM 4.86E-10 TRP & mitochondrial translation 15 2.28E-12
9 SGTC_1623 st003709 6.42 20.3 µM 7.10E-9 calcium & mitochondrial duress 10 7.03E-11
10 SGTC_903 1134-0042 5.12 114.0 µM 2.98E-6 8 1.56E-7
11 SGTC_876 0720-0963 5.11 56.8 µM 3.05E-6 5 1.61E-7
12 SGTC_2352 9027995 5.00 87.8 µM 4.75E-6 tubulin folding & SWR complex 20 2.83E-7
13 SGTC_386 1509-0011 5.00 3.1 µM 4.87E-6 108 2.93E-7
14 SGTC_791 1348-1292 4.99 225.0 µM 5.01E-6 18 3.03E-7
15 SGTC_63 0099-0242 4.88 26.7 µM 7.78E-6 mitochondrial stress 61 5.30E-7
16 SGTC_1742 st038235 4.86 28.9 µM 8.32E-6 mitochondrial stress 84 5.77E-7
17 SGTC_1622 st003707 4.81 19.4 µM 1.03E-5 calcium & mitochondrial duress 19 7.62E-7
18 SGTC_10 0279-0212 4.76 42.6 µM 1.24E-5 TRP & mitochondrial translation 73 9.58E-7
19 SGTC_2232 chlorophetanol 4.63 41.5 µM 2.06E-5 TRP & mitochondrial translation 97 1.83E-6
20 SGTC_2926 9010726 4.57 65.2 µM 2.62E-5 22 2.48E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.546 2.23E-260 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.539 1.75E-252 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.519 1.93E-231 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.510 1.52E-220 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.506 1.70E-217 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.505 1.29E-216 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.503 4.17E-214 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.498 5.48E-210 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.498 1.42E-209 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.492 5.19E-204 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.491 1.04E-202 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.483 9.71E-196 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.479 5.27E-192 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.478 5.99E-191 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.473 1.78E-186 YCR071C IMG2 hom Mitochondrial ribosomal protein of the large subunit