YNL200C

NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL200C / YNL200C

Click on Significant Values for Screen Details ID:SGTC_56|Compound:0957-0365|FD-Score:3.14|P-value:3.32E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.13|P-value:3.47E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-2.98|P-value:6.30E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.84|P-value:1.56E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.25|P-value:2.25E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:4.26|P-value:1.92E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.08|P-value:4.29E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.19|P-value:2.77E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.94|P-value:9.73E-6 ID:SGTC_577|Compound:r071-0003|FD-Score:2.93|P-value:7.58E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.06|P-value:4.50E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.57|P-value:5.36E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.18|P-value:2.84E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.09|P-value:4.10E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:2.97|P-value:6.30E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-2.91|P-value:8.36E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.60|P-value:4.72E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.25|P-value:2.24E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.95|P-value:9.62E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-2.93|P-value:7.69E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.70|P-value:3.16E-5 ID:SGTC_1749|Compound:st037932|FD-Score:3.25|P-value:2.15E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.93|P-value:1.04E-5 ID:SGTC_1948|Compound:st076329|FD-Score:3.05|P-value:4.78E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-3.71|P-value:3.07E-5 ID:SGTC_2027|Compound:5150920|FD-Score:3.39|P-value:1.18E-4 ID:SGTC_2028|Compound:5153890|FD-Score:5.53|P-value:1.04E-9 ID:SGTC_2035|Compound:5154463|FD-Score:3.09|P-value:4.07E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.30|P-value:1.75E-4 ID:SGTC_2106|Compound:5357045|FD-Score:-3.42|P-value:1.11E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.56|P-value:5.70E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.15|P-value:3.17E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:2.86|P-value:9.68E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.28|P-value:1.92E-4 ID:SGTC_2796|Compound:7949634|FD-Score:2.95|P-value:6.83E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.48|P-value:7.94E-5 ID:SGTC_3324|Compound:9138759|FD-Score:2.87|P-value:9.13E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.14|P-value:3.32E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.13|P-value:3.47E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-2.98|P-value:6.30E-4 ID:SGTC_110|Compound:0850-0284|FD-Score:3.84|P-value:1.56E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:-3.25|P-value:2.25E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:4.26|P-value:1.92E-6 ID:SGTC_149|Compound:3970-0822|FD-Score:-3.08|P-value:4.29E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:3.19|P-value:2.77E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.94|P-value:9.73E-6 ID:SGTC_577|Compound:r071-0003|FD-Score:2.93|P-value:7.58E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:3.06|P-value:4.50E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:3.57|P-value:5.36E-5 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.18|P-value:2.84E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:-3.09|P-value:4.10E-4 ID:SGTC_1267|Compound:0828-0272|FD-Score:2.97|P-value:6.30E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:-2.91|P-value:8.36E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.60|P-value:4.72E-5 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.25|P-value:2.24E-4 ID:SGTC_1594|Compound:piperine|FD-Score:-3.95|P-value:9.62E-6 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-2.93|P-value:7.69E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.70|P-value:3.16E-5 ID:SGTC_1749|Compound:st037932|FD-Score:3.25|P-value:2.15E-4 ID:SGTC_1828|Compound:st055811|FD-Score:3.93|P-value:1.04E-5 ID:SGTC_1948|Compound:st076329|FD-Score:3.05|P-value:4.78E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-3.71|P-value:3.07E-5 ID:SGTC_2027|Compound:5150920|FD-Score:3.39|P-value:1.18E-4 ID:SGTC_2028|Compound:5153890|FD-Score:5.53|P-value:1.04E-9 ID:SGTC_2035|Compound:5154463|FD-Score:3.09|P-value:4.07E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.30|P-value:1.75E-4 ID:SGTC_2106|Compound:5357045|FD-Score:-3.42|P-value:1.11E-4 ID:SGTC_2123|Compound:5259487|FD-Score:3.56|P-value:5.70E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.15|P-value:3.17E-4 ID:SGTC_2667|Compound:digitoxin|FD-Score:2.86|P-value:9.68E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.28|P-value:1.92E-4 ID:SGTC_2796|Compound:7949634|FD-Score:2.95|P-value:6.83E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.48|P-value:7.94E-5 ID:SGTC_3324|Compound:9138759|FD-Score:2.87|P-value:9.13E-4

Top fitness defect scores for YNL200C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2028 5153890 5.53 36.4 µM 1.04E-9 cell wall signaling 13 1.61E-8
2 SGTC_148 3253-0744 4.26 288.0 µM 1.92E-6 11 1.01E-5
3 SGTC_530 4358-1714 3.94 28.0 µM 9.73E-6 46 4.06E-5
4 SGTC_1828 st055811 3.93 49.0 µM 1.04E-5 8 4.29E-5
5 SGTC_110 0850-0284 3.84 111.6 µM 1.56E-5 18 6.10E-5
6 SGTC_1456 k015-0012 3.60 13.0 µM 4.72E-5 44 1.58E-4
7 SGTC_817 1391-0715 3.57 46.0 µM 5.36E-5 26 1.76E-4
8 SGTC_2123 5259487 3.56 200.0 µM 5.70E-5 25 1.86E-4
9 SGTC_3212 9128307 3.48 49.5 µM 7.94E-5 67 2.47E-4
10 SGTC_2027 5150920 3.39 200.0 µM 1.18E-4 28 3.46E-4
11 SGTC_2038 4100038 3.30 31.0 µM 1.75E-4 plasma membrane duress 80 4.87E-4
12 SGTC_2692 st077426 3.28 47.7 µM 1.92E-4 46 5.27E-4
13 SGTC_1749 st037932 3.25 54.2 µM 2.15E-4 49 5.81E-4
14 SGTC_378 3970-0959 3.19 8.3 µM 2.77E-4 39 7.23E-4
15 SGTC_1127 asiatic acid 3.18 681.4 nM 2.84E-4 56 7.40E-4
16 SGTC_2407 paclitaxel 3.15 400.0 µM 3.17E-4 75 8.13E-4
17 SGTC_56 0957-0365 3.14 83.2 µM 3.32E-4 Golgi 86 8.46E-4
18 SGTC_57 miconazole 3.13 162.5 nM 3.47E-4 ergosterol depletion effects on membrane 54 8.79E-4
19 SGTC_2035 5154463 3.09 94.6 µM 4.07E-4 49 0.00101
20 SGTC_798 1287-0182 3.06 476.0 µM 4.50E-4 61 0.00110

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.17E-10 YMR235C RNA1 het GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
0.105 9.70E-10 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.105 1.11E-9 YDR510W SMT3 het Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
0.098 1.47E-8 YOR055W_d YOR055W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.69E-8 YMR183C SSO2 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
0.088 3.05E-7 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.084 1.14E-6 YHR022C_p YHR022C_p hom Putative protein of unknown function; YHR022C is not an essential gene
0.078 6.37E-6 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.077 7.11E-6 YBR197C YBR197C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication
0.077 7.46E-6 YDR356W SPC110 het Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
0.077 8.35E-6 YAL065C_p YAL065C_p hom Putative protein of unknown function; has homology to FLO1; possible pseudogene
0.077 9.03E-6 YAR020C PAU7 hom Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
0.076 9.38E-6 YNL065W AQR1 hom Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.075 1.32E-5 YJL078C PRY3 hom Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
0.074 1.79E-5 YNL159C ASI2 hom Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals