YNL201C / PSY2

Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL201C / PSY2

Click on Significant Values for Screen Details ID:SGTC_67|Compound:0335-0847|FD-Score:-3.10|P-value:5.14E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.51|P-value:2.90E-4 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.20|P-value:8.80E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.17|P-value:1.96E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.81|P-value:9.23E-7 ID:SGTC_505|Compound:gw-5074|FD-Score:3.38|P-value:4.54E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.36|P-value:5.00E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.41|P-value:1.59E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.18|P-value:9.43E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.47|P-value:3.30E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.35|P-value:5.15E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.32|P-value:5.82E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.63|P-value:1.83E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.07|P-value:2.41E-7 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.60|P-value:2.05E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.93|P-value:5.32E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.20|P-value:8.87E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.47|P-value:3.27E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.82|P-value:8.82E-7 ID:SGTC_1526|Compound:st051518|FD-Score:5.02|P-value:3.11E-7 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:5.14|P-value:1.64E-7 ID:SGTC_1650|Compound:st011916|FD-Score:-3.01|P-value:6.95E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.65|P-value:9.11E-9 ID:SGTC_1757|Compound:st041620|FD-Score:-3.30|P-value:2.39E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-3.05|P-value:6.10E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.32|P-value:2.29E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.52|P-value:2.80E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.25|P-value:7.39E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-5.28|P-value:1.86E-8 ID:SGTC_2301|Compound:7769476|FD-Score:-3.94|P-value:1.75E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.36|P-value:4.89E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.82|P-value:8.83E-7 ID:SGTC_2391|Compound:6285546|FD-Score:4.63|P-value:2.30E-6 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.67|P-value:5.65E-5 ID:SGTC_2517|Compound:totarol|FD-Score:-3.52|P-value:1.02E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.51|P-value:1.08E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.74|P-value:4.15E-5 ID:SGTC_2834|Compound:9001755|FD-Score:5.08|P-value:2.30E-7 ID:SGTC_2942|Compound:9052777|FD-Score:-10.10|P-value:8.90E-26 ID:SGTC_2943|Compound:9068529|FD-Score:-5.67|P-value:1.76E-9 ID:SGTC_2944|Compound:9067346|FD-Score:-7.01|P-value:1.92E-13 ID:SGTC_2947|Compound:9072639|FD-Score:7.37|P-value:8.47E-14 ID:SGTC_2953|Compound:9074162|FD-Score:-3.47|P-value:1.25E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.27|P-value:6.79E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.77|P-value:4.53E-9 ID:SGTC_3166|Compound:9102297|FD-Score:5.97|P-value:1.31E-9 ID:SGTC_3185|Compound:9108267|FD-Score:4.31|P-value:1.03E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.79|P-value:9.59E-5 ID:SGTC_3249|Compound:9135183|FD-Score:4.85|P-value:7.52E-7 ID:SGTC_67|Compound:0335-0847|FD-Score:-3.10|P-value:5.14E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:3.51|P-value:2.90E-4 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.20|P-value:8.80E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:4.17|P-value:1.96E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.81|P-value:9.23E-7 ID:SGTC_505|Compound:gw-5074|FD-Score:3.38|P-value:4.54E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.36|P-value:5.00E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.41|P-value:1.59E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.18|P-value:9.43E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.47|P-value:3.30E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.35|P-value:5.15E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.32|P-value:5.82E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.63|P-value:1.83E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.07|P-value:2.41E-7 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.60|P-value:2.05E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:3.93|P-value:5.32E-5 ID:SGTC_1218|Compound:1348-1416|FD-Score:3.20|P-value:8.87E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.47|P-value:3.27E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:4.82|P-value:8.82E-7 ID:SGTC_1526|Compound:st051518|FD-Score:5.02|P-value:3.11E-7 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:5.14|P-value:1.64E-7 ID:SGTC_1650|Compound:st011916|FD-Score:-3.01|P-value:6.95E-4 ID:SGTC_1707|Compound:st032323|FD-Score:5.65|P-value:9.11E-9 ID:SGTC_1757|Compound:st041620|FD-Score:-3.30|P-value:2.39E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-3.05|P-value:6.10E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:-3.32|P-value:2.29E-4 ID:SGTC_2064|Compound:5220758|FD-Score:3.52|P-value:2.80E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.25|P-value:7.39E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-5.28|P-value:1.86E-8 ID:SGTC_2301|Compound:7769476|FD-Score:-3.94|P-value:1.75E-5 ID:SGTC_2302|Compound:7771753|FD-Score:3.36|P-value:4.89E-4 ID:SGTC_2377|Compound:9073351|FD-Score:4.82|P-value:8.83E-7 ID:SGTC_2391|Compound:6285546|FD-Score:4.63|P-value:2.30E-6 ID:SGTC_2515|Compound:chrysin|FD-Score:-3.67|P-value:5.65E-5 ID:SGTC_2517|Compound:totarol|FD-Score:-3.52|P-value:1.02E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.51|P-value:1.08E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.74|P-value:4.15E-5 ID:SGTC_2834|Compound:9001755|FD-Score:5.08|P-value:2.30E-7 ID:SGTC_2942|Compound:9052777|FD-Score:-10.10|P-value:8.90E-26 ID:SGTC_2943|Compound:9068529|FD-Score:-5.67|P-value:1.76E-9 ID:SGTC_2944|Compound:9067346|FD-Score:-7.01|P-value:1.92E-13 ID:SGTC_2947|Compound:9072639|FD-Score:7.37|P-value:8.47E-14 ID:SGTC_2953|Compound:9074162|FD-Score:-3.47|P-value:1.25E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.27|P-value:6.79E-4 ID:SGTC_3142|Compound:9086498|FD-Score:5.77|P-value:4.53E-9 ID:SGTC_3166|Compound:9102297|FD-Score:5.97|P-value:1.31E-9 ID:SGTC_3185|Compound:9108267|FD-Score:4.31|P-value:1.03E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.79|P-value:9.59E-5 ID:SGTC_3249|Compound:9135183|FD-Score:4.85|P-value:7.52E-7

Top fitness defect scores for YNL201C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2947 9072639 7.37 7.7 µM 8.47E-14 tubulin folding & SWR complex 9 8.77E-14
2 SGTC_3166 9102297 5.97 49.5 µM 1.31E-9 Golgi 13 1.15E-9
3 SGTC_3142 9086498 5.77 49.5 µM 4.53E-9 iron homeostasis 8 3.92E-9
4 SGTC_1707 st032323 5.65 6.3 µM 9.11E-9 DNA damage response 23 7.82E-9
5 SGTC_1543 azetidyl-2-carboxylic acid 5.14 198.0 µM 1.64E-7 2 1.36E-7
6 SGTC_2834 9001755 5.08 58.4 µM 2.30E-7 15 1.90E-7
7 SGTC_1082 camptothecin 5.07 424.9 nM 2.41E-7 DNA damage response 30 1.98E-7
8 SGTC_1526 st051518 5.02 75.0 µM 3.11E-7 5 2.56E-7
9 SGTC_3249 9135183 4.85 49.5 µM 7.52E-7 60S ribosome export 4 6.13E-7
10 SGTC_1381 2324-0066 4.82 62.1 µM 8.82E-7 17 7.17E-7
11 SGTC_2377 9073351 4.82 62.6 µM 8.83E-7 ergosterol biosynthesis 13 7.18E-7
12 SGTC_491 tetrandrine 4.81 80.3 µM 9.23E-7 4 7.51E-7
13 SGTC_2391 6285546 4.63 200.0 µM 2.30E-6 6 1.85E-6
14 SGTC_3185 9108267 4.31 49.5 µM 1.03E-5 60S ribosome export 11 8.21E-6
15 SGTC_439 amiodarone 4.17 34.4 µM 1.96E-5 NEO1-PIK1 90 1.55E-5
16 SGTC_1215 3852-0577 3.93 11.2 µM 5.32E-5 16 4.20E-5
17 SGTC_3233 9132340 3.79 49.5 µM 9.59E-5 22 7.55E-5
18 SGTC_1078 idebenone 3.63 36.1 µM 1.83E-4 Golgi 55 1.43E-4
19 SGTC_1164 k060-0068 3.60 93.7 µM 2.05E-4 41 1.61E-4
20 SGTC_2064 5220758 3.52 200.0 µM 2.80E-4 54 2.20E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.189 2.44E-28 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.122 1.49E-12 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.118 7.38E-12 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.117 9.37E-12 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.116 1.56E-11 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.113 4.53E-11 YDR304C CPR5 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
0.108 3.79E-10 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.105 1.13E-9 YMR226C YMR226C hom NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments
0.102 3.39E-9 YLR316C TAD3 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs
0.097 1.88E-8 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.094 4.22E-8 YIL120W QDR1 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication
0.091 1.38E-7 YJL142C_d IRC9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci
0.091 1.39E-7 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.089 2.40E-7 YIL020C HIS6 hom Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
0.087 4.29E-7 YDR369C XRS2 hom Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling