YNL209W / SSB2

Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL209W / SSB2

Click on Significant Values for Screen Details ID:SGTC_80|Compound:0159-0065|FD-Score:2.61|P-value:5.97E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-2.69|P-value:6.51E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.22|P-value:1.87E-7 ID:SGTC_375|Compound:3970-0961|FD-Score:-2.84|P-value:3.36E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:2.58|P-value:6.81E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:2.65|P-value:5.04E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-2.70|P-value:6.25E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.99|P-value:1.03E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:2.58|P-value:6.78E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.11|P-value:5.99E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.04|P-value:1.34E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:2.84|P-value:2.14E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.22|P-value:3.44E-5 ID:SGTC_1606|Compound:st000094|FD-Score:3.87|P-value:8.85E-7 ID:SGTC_1607|Compound:st000305|FD-Score:2.55|P-value:7.64E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-2.63|P-value:8.49E-4 ID:SGTC_1619|Compound:st003326|FD-Score:4.21|P-value:1.01E-7 ID:SGTC_1724|Compound:st037281|FD-Score:-2.71|P-value:6.06E-4 ID:SGTC_1851|Compound:st056236|FD-Score:2.64|P-value:5.15E-4 ID:SGTC_2167|Compound:5876490|FD-Score:2.68|P-value:4.45E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.97|P-value:1.90E-4 ID:SGTC_2257|Compound:7960413|FD-Score:2.71|P-value:3.83E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-2.69|P-value:6.57E-4 ID:SGTC_2462|Compound:5162487|FD-Score:2.89|P-value:1.68E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.13|P-value:8.79E-5 ID:SGTC_80|Compound:0159-0065|FD-Score:2.61|P-value:5.97E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-2.69|P-value:6.51E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-4.22|P-value:1.87E-7 ID:SGTC_375|Compound:3970-0961|FD-Score:-2.84|P-value:3.36E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:2.58|P-value:6.81E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:2.65|P-value:5.04E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-2.70|P-value:6.25E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.99|P-value:1.03E-4 ID:SGTC_938|Compound:3126-1755|FD-Score:2.58|P-value:6.78E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.11|P-value:5.99E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.04|P-value:1.34E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:2.84|P-value:2.14E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.22|P-value:3.44E-5 ID:SGTC_1606|Compound:st000094|FD-Score:3.87|P-value:8.85E-7 ID:SGTC_1607|Compound:st000305|FD-Score:2.55|P-value:7.64E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-2.63|P-value:8.49E-4 ID:SGTC_1619|Compound:st003326|FD-Score:4.21|P-value:1.01E-7 ID:SGTC_1724|Compound:st037281|FD-Score:-2.71|P-value:6.06E-4 ID:SGTC_1851|Compound:st056236|FD-Score:2.64|P-value:5.15E-4 ID:SGTC_2167|Compound:5876490|FD-Score:2.68|P-value:4.45E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-2.97|P-value:1.90E-4 ID:SGTC_2257|Compound:7960413|FD-Score:2.71|P-value:3.83E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-2.69|P-value:6.57E-4 ID:SGTC_2462|Compound:5162487|FD-Score:2.89|P-value:1.68E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.13|P-value:8.79E-5

Top fitness defect scores for YNL209W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1619 st003326 4.21 88.7 µM 1.01E-7 60S ribosome export 15 1.26E-5
2 SGTC_1606 st000094 3.87 49.2 µM 8.85E-7 60S ribosome export 20 5.45E-5
3 SGTC_1230 0170-0365 3.22 3.8 µM 3.44E-5 endomembrane recycling 116 6.52E-4
4 SGTC_1058 3448-5425 3.11 97.3 µM 5.99E-5 57 9.51E-4
5 SGTC_934 2950-0684 2.99 338.0 µM 1.03E-4 58 0.00137
6 SGTC_2462 5162487 2.89 171.8 µM 1.68E-4 59 0.00192
7 SGTC_1200 1643-0193 2.84 18.4 µM 2.14E-4 57 0.00226
8 SGTC_2257 7960413 2.71 200.0 µM 3.83E-4 NEO1-PIK1 148 0.00336
9 SGTC_2167 5876490 2.68 200.0 µM 4.45E-4 104 0.00373
10 SGTC_564 3555-0129 2.65 330.0 µM 5.04E-4 44 0.00406
11 SGTC_1851 st056236 2.64 18.9 µM 5.15E-4 91 0.00412
12 SGTC_80 0159-0065 2.61 512.2 µM 5.97E-4 37 0.00456
13 SGTC_938 3126-1755 2.58 342.0 µM 6.78E-4 88 0.00497
14 SGTC_540 1187-0821 2.58 17.3 µM 6.81E-4 108 0.00499
15 SGTC_1607 st000305 2.55 50.6 µM 7.64E-4 96 0.00539
16 SGTC_2303 7774051 2.46 200.0 µM 0.00110 116 0.00694
17 SGTC_617 3770-0098 2.45 35.0 µM 0.00113 exosome 97 0.00706
18 SGTC_155 k072-0202 2.43 43.6 µM 0.00127 106 0.00762
19 SGTC_288 1315-0019 2.42 35.1 µM 0.00132 RSC & ERG11 126 0.00784
20 SGTC_1219 1469-0211 2.42 33.1 µM 0.00132 93 0.00786

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 1.52E-35 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.184 5.69E-27 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p
0.175 1.93E-24 YDR295C HDA2 hom Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
0.163 2.34E-21 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.156 1.05E-19 YDR501W PLM2 hom Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication
0.156 1.19E-19 YDR257C RKM4 hom Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein
0.137 1.57E-15 YER109C FLO8 hom Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
0.136 2.50E-15 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.133 9.92E-15 YMR134W ERG29 het Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.133 1.06E-14 YOL043C NTG2 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication
0.127 1.34E-13 YDR107C TMN2 hom Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments
0.127 1.51E-13 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.123 8.05E-13 YDL128W VCX1 hom Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
0.123 9.47E-13 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.123 9.62E-13 YDR109C_p YDR109C_p hom Putative kinase