YNL212W / VID27

Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL212W / VID27

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.32|P-value:4.24E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.27|P-value:8.66E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:3.11|P-value:8.83E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.82|P-value:6.25E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.61|P-value:1.40E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.44|P-value:2.79E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.43|P-value:2.84E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:5.16|P-value:1.09E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:3.84|P-value:5.68E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:3.54|P-value:1.87E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.08|P-value:2.04E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.45|P-value:2.67E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.25|P-value:9.81E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:5.96|P-value:1.02E-9 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.25|P-value:5.34E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.50|P-value:2.13E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.86|P-value:5.27E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:7.60|P-value:1.12E-14 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.27|P-value:5.18E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.67|P-value:1.14E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.10|P-value:9.20E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.23|P-value:1.07E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.38|P-value:3.44E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.74|P-value:8.44E-5 ID:SGTC_1745|Compound:st081495|FD-Score:3.16|P-value:7.40E-4 ID:SGTC_1822|Compound:st052468|FD-Score:3.44|P-value:2.69E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.33|P-value:6.85E-6 ID:SGTC_2063|Compound:5246145|FD-Score:3.54|P-value:1.87E-4 ID:SGTC_2105|Compound:5350118|FD-Score:5.31|P-value:4.71E-8 ID:SGTC_2236|Compound:dapsone|FD-Score:3.21|P-value:6.29E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.13|P-value:8.13E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.88|P-value:4.86E-5 ID:SGTC_2402|Compound:5553605|FD-Score:4.13|P-value:1.61E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:8.71|P-value:1.02E-18 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.52|P-value:2.00E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.61|P-value:1.47E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-3.65|P-value:1.22E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.42|P-value:2.94E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.65|P-value:1.20E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.32|P-value:4.24E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:4.27|P-value:8.66E-6 ID:SGTC_167|Compound:3672-0051|FD-Score:3.11|P-value:8.83E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.82|P-value:6.25E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.61|P-value:1.40E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:-3.44|P-value:2.79E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.43|P-value:2.84E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:5.16|P-value:1.09E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:3.84|P-value:5.68E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:3.54|P-value:1.87E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:4.08|P-value:2.04E-5 ID:SGTC_1000|Compound:4048-0884|FD-Score:-3.45|P-value:2.67E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:4.25|P-value:9.81E-6 ID:SGTC_1033|Compound:k072-0102|FD-Score:5.96|P-value:1.02E-9 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.25|P-value:5.34E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.50|P-value:2.13E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.86|P-value:5.27E-5 ID:SGTC_1250|Compound:0485-0349|FD-Score:7.60|P-value:1.12E-14 ID:SGTC_1324|Compound:1418-0026|FD-Score:-3.27|P-value:5.18E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.67|P-value:1.14E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.10|P-value:9.20E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:4.23|P-value:1.07E-5 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.38|P-value:3.44E-4 ID:SGTC_1632|Compound:st005650|FD-Score:3.74|P-value:8.44E-5 ID:SGTC_1745|Compound:st081495|FD-Score:3.16|P-value:7.40E-4 ID:SGTC_1822|Compound:st052468|FD-Score:3.44|P-value:2.69E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.33|P-value:6.85E-6 ID:SGTC_2063|Compound:5246145|FD-Score:3.54|P-value:1.87E-4 ID:SGTC_2105|Compound:5350118|FD-Score:5.31|P-value:4.71E-8 ID:SGTC_2236|Compound:dapsone|FD-Score:3.21|P-value:6.29E-4 ID:SGTC_2382|Compound:9035899|FD-Score:3.13|P-value:8.13E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.88|P-value:4.86E-5 ID:SGTC_2402|Compound:5553605|FD-Score:4.13|P-value:1.61E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:8.71|P-value:1.02E-18 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.52|P-value:2.00E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-3.61|P-value:1.47E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-3.65|P-value:1.22E-4 ID:SGTC_2921|Compound:7974240|FD-Score:-3.42|P-value:2.94E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.65|P-value:1.20E-4

Top fitness defect scores for YNL212W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2563 tomatine 8.71 8.5 µM 1.02E-18 2 1.51E-18
2 SGTC_1250 0485-0349 7.60 40.2 µM 1.12E-14 3 1.52E-14
3 SGTC_1033 k072-0102 5.96 21.3 µM 1.02E-9 60S ribosome export 3 1.24E-9
4 SGTC_2105 5350118 5.31 200.0 µM 4.71E-8 9 5.50E-8
5 SGTC_685 1278-0033 5.16 54.9 µM 1.09E-7 60S ribosome export 6 1.26E-7
6 SGTC_2017 5132927 4.33 60.6 µM 6.85E-6 23 7.62E-6
7 SGTC_137 0438-0332 4.27 85.4 µM 8.66E-6 ubiquinone biosynthesis & proteasome 106 9.62E-6
8 SGTC_1032 k061-1018 4.25 98.7 µM 9.81E-6 14 1.09E-5
9 SGTC_1464 k208-0027 4.23 110.0 µM 1.07E-5 20 1.18E-5
10 SGTC_2402 5553605 4.13 200.0 µM 1.61E-5 17 1.78E-5
11 SGTC_927 2425-1185 4.08 123.0 µM 2.04E-5 25 2.24E-5
12 SGTC_1151 3909-8316 3.86 15.3 µM 5.27E-5 20 5.74E-5
13 SGTC_704 1310-0270 3.84 142.0 µM 5.68E-5 36 6.19E-5
14 SGTC_1632 st005650 3.74 90.0 µM 8.44E-5 36 9.16E-5
15 SGTC_1360 1598-0022 3.67 39.8 µM 1.14E-4 ERG2 42 1.23E-4
16 SGTC_3205 9113483 3.65 49.5 µM 1.20E-4 38 1.30E-4
17 SGTC_454 lyso-paf C-16 3.61 6.7 µM 1.40E-4 28 1.51E-4
18 SGTC_885 0865-0106 3.54 16.8 µM 1.87E-4 TSC3-RPN4 40 2.02E-4
19 SGTC_2063 5246145 3.54 200.0 µM 1.87E-4 34 2.02E-4
20 SGTC_2684 capsaicin 3.52 100.0 µM 2.00E-4 23 2.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.16E-20 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.119 4.75E-12 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.117 9.52E-12 YDR018C_p YDR018C_p hom Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication
0.115 2.18E-11 YPR083W MDM36 hom Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission
0.109 2.14E-10 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.105 9.49E-10 YGR138C TPO2 hom Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication
0.101 4.10E-9 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.097 1.77E-8 YGR153W_p YGR153W_p hom Putative protein of unknown function
0.097 1.90E-8 YOR165W SEY1 hom Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3
0.095 3.96E-8 YDR328C SKP1 het Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress
0.089 2.20E-7 YMR221C_p YMR221C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
0.088 2.85E-7 YMR011W HXT2 hom High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
0.088 3.02E-7 YKR080W MTD1 hom NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
0.088 3.54E-7 YDR001C NTH1 hom Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication
0.088 3.67E-7 YJL020C BBC1 hom Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches