YNL220W / ADE12

Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL220W / ADE12

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:-3.51|P-value:5.66E-5 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:-6.99|P-value:9.00E-15 ID:SGTC_52|Compound:0329-0193|FD-Score:3.47|P-value:8.18E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:-2.89|P-value:7.36E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.80|P-value:6.99E-8 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.25|P-value:1.76E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:-4.07|P-value:3.86E-6 ID:SGTC_624|Compound:k048-0052|FD-Score:3.04|P-value:4.76E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.00|P-value:4.79E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-2.88|P-value:7.68E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.31|P-value:1.63E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.06|P-value:3.79E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.19|P-value:2.27E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-5.19|P-value:6.42E-9 ID:SGTC_1088|Compound:bifonazole|FD-Score:-4.23|P-value:1.71E-6 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.89|P-value:9.55E-6 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.17|P-value:2.42E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-7.91|P-value:2.26E-18 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.01|P-value:4.66E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.30|P-value:1.41E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.69|P-value:2.48E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.54|P-value:4.93E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.09|P-value:3.99E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:2.88|P-value:8.80E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.57|P-value:5.10E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.44|P-value:7.96E-5 ID:SGTC_1563|Compound:conessine|FD-Score:3.64|P-value:3.78E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.18|P-value:2.78E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:4.11|P-value:3.79E-6 ID:SGTC_1632|Compound:st005650|FD-Score:-3.49|P-value:6.36E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-3.58|P-value:4.16E-5 ID:SGTC_1799|Compound:st045822|FD-Score:2.88|P-value:8.86E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.16|P-value:2.96E-4 ID:SGTC_2156|Compound:5649887|FD-Score:2.88|P-value:8.83E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.19|P-value:2.61E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.21|P-value:2.39E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.04|P-value:4.87E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.48|P-value:5.27E-7 ID:SGTC_2359|Compound:9039622|FD-Score:4.96|P-value:3.22E-8 ID:SGTC_2367|Compound:9070478|FD-Score:5.77|P-value:1.62E-10 ID:SGTC_2372|Compound:9071633|FD-Score:3.49|P-value:7.46E-5 ID:SGTC_2386|Compound:9075165|FD-Score:4.22|P-value:2.19E-6 ID:SGTC_2399|Compound:5884133|FD-Score:-3.93|P-value:7.94E-6 ID:SGTC_2400|Compound:5203494|FD-Score:-3.22|P-value:1.98E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.42|P-value:8.69E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-2.83|P-value:9.34E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.07|P-value:3.73E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.67|P-value:2.71E-5 ID:SGTC_2464|Compound:5717415|FD-Score:-5.37|P-value:1.89E-9 ID:SGTC_2475|Compound:5812728|FD-Score:-2.88|P-value:7.55E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-4.41|P-value:6.58E-7 ID:SGTC_2514|Compound:salinomycin|FD-Score:5.12|P-value:1.25E-8 ID:SGTC_2537|Compound:larixol|FD-Score:4.47|P-value:5.69E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.40|P-value:9.15E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-5.08|P-value:1.29E-8 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.01|P-value:4.72E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.45|P-value:7.65E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-17.80|P-value:1.14E-84 ID:SGTC_2620|Compound:irigenin|FD-Score:-18.50|P-value:8.83E-92 ID:SGTC_2625|Compound:euphol|FD-Score:4.33|P-value:1.21E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.81|P-value:1.45E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:-3.39|P-value:9.82E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-4.57|P-value:2.64E-7 ID:SGTC_2726|Compound:cimetidine|FD-Score:-4.40|P-value:6.97E-7 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.71|P-value:2.28E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:-2.88|P-value:7.61E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.50|P-value:6.00E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.74|P-value:2.03E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-5.11|P-value:1.01E-8 ID:SGTC_2880|Compound:9042983|FD-Score:-4.12|P-value:3.00E-6 ID:SGTC_2891|Compound:9063876|FD-Score:3.32|P-value:1.53E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.40|P-value:1.11E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.04|P-value:4.13E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.42|P-value:9.94E-5 ID:SGTC_3093|Compound:9117344|FD-Score:2.96|P-value:6.61E-4 ID:SGTC_3107|Compound:9121808|FD-Score:2.85|P-value:9.78E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-3.00|P-value:4.84E-4 ID:SGTC_3191|Compound:9110352|FD-Score:2.98|P-value:6.02E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-3.04|P-value:4.14E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.01|P-value:5.40E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.04|P-value:4.86E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-3.51|P-value:5.83E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.51|P-value:5.84E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.48|P-value:7.90E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.27|P-value:1.93E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.51|P-value:5.66E-5 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:-6.99|P-value:9.00E-15 ID:SGTC_52|Compound:0329-0193|FD-Score:3.47|P-value:8.18E-5 ID:SGTC_331|Compound:k048-0133|FD-Score:-2.89|P-value:7.36E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:-4.80|P-value:6.99E-8 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.25|P-value:1.76E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:-4.07|P-value:3.86E-6 ID:SGTC_624|Compound:k048-0052|FD-Score:3.04|P-value:4.76E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-3.00|P-value:4.79E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-2.88|P-value:7.68E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.31|P-value:1.63E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.06|P-value:3.79E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-3.19|P-value:2.27E-4 ID:SGTC_1087|Compound:pterostilbene|FD-Score:-5.19|P-value:6.42E-9 ID:SGTC_1088|Compound:bifonazole|FD-Score:-4.23|P-value:1.71E-6 ID:SGTC_1089|Compound:terbinafine|FD-Score:-3.89|P-value:9.55E-6 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.17|P-value:2.42E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-7.91|P-value:2.26E-18 ID:SGTC_1096|Compound:rimcazole|FD-Score:-3.01|P-value:4.66E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.30|P-value:1.41E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.69|P-value:2.48E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.54|P-value:4.93E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.09|P-value:3.99E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:2.88|P-value:8.80E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.57|P-value:5.10E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:-3.44|P-value:7.96E-5 ID:SGTC_1563|Compound:conessine|FD-Score:3.64|P-value:3.78E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.18|P-value:2.78E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:4.11|P-value:3.79E-6 ID:SGTC_1632|Compound:st005650|FD-Score:-3.49|P-value:6.36E-5 ID:SGTC_1713|Compound:st033146|FD-Score:-3.58|P-value:4.16E-5 ID:SGTC_1799|Compound:st045822|FD-Score:2.88|P-value:8.86E-4 ID:SGTC_2107|Compound:5363541|FD-Score:3.16|P-value:2.96E-4 ID:SGTC_2156|Compound:5649887|FD-Score:2.88|P-value:8.83E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.19|P-value:2.61E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.21|P-value:2.39E-4 ID:SGTC_2305|Compound:7443522|FD-Score:3.04|P-value:4.87E-4 ID:SGTC_2316|Compound:5844804|FD-Score:4.48|P-value:5.27E-7 ID:SGTC_2359|Compound:9039622|FD-Score:4.96|P-value:3.22E-8 ID:SGTC_2367|Compound:9070478|FD-Score:5.77|P-value:1.62E-10 ID:SGTC_2372|Compound:9071633|FD-Score:3.49|P-value:7.46E-5 ID:SGTC_2386|Compound:9075165|FD-Score:4.22|P-value:2.19E-6 ID:SGTC_2399|Compound:5884133|FD-Score:-3.93|P-value:7.94E-6 ID:SGTC_2400|Compound:5203494|FD-Score:-3.22|P-value:1.98E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-3.42|P-value:8.69E-5 ID:SGTC_2403|Compound:6032726|FD-Score:-2.83|P-value:9.34E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.07|P-value:3.73E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.67|P-value:2.71E-5 ID:SGTC_2464|Compound:5717415|FD-Score:-5.37|P-value:1.89E-9 ID:SGTC_2475|Compound:5812728|FD-Score:-2.88|P-value:7.55E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-4.41|P-value:6.58E-7 ID:SGTC_2514|Compound:salinomycin|FD-Score:5.12|P-value:1.25E-8 ID:SGTC_2537|Compound:larixol|FD-Score:4.47|P-value:5.69E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.40|P-value:9.15E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-5.08|P-value:1.29E-8 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.01|P-value:4.72E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.45|P-value:7.65E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-17.80|P-value:1.14E-84 ID:SGTC_2620|Compound:irigenin|FD-Score:-18.50|P-value:8.83E-92 ID:SGTC_2625|Compound:euphol|FD-Score:4.33|P-value:1.21E-6 ID:SGTC_2630|Compound:antimycin a|FD-Score:-3.81|P-value:1.45E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:-3.39|P-value:9.82E-5 ID:SGTC_2725|Compound:haloperidol|FD-Score:-4.57|P-value:2.64E-7 ID:SGTC_2726|Compound:cimetidine|FD-Score:-4.40|P-value:6.97E-7 ID:SGTC_2727|Compound:riluzole|FD-Score:-3.71|P-value:2.28E-5 ID:SGTC_2730|Compound:imipramine|FD-Score:-2.88|P-value:7.61E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.50|P-value:6.00E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-3.74|P-value:2.03E-5 ID:SGTC_2848|Compound:9016370|FD-Score:-5.11|P-value:1.01E-8 ID:SGTC_2880|Compound:9042983|FD-Score:-4.12|P-value:3.00E-6 ID:SGTC_2891|Compound:9063876|FD-Score:3.32|P-value:1.53E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.40|P-value:1.11E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.04|P-value:4.13E-4 ID:SGTC_3003|Compound:9075612|FD-Score:3.42|P-value:9.94E-5 ID:SGTC_3093|Compound:9117344|FD-Score:2.96|P-value:6.61E-4 ID:SGTC_3107|Compound:9121808|FD-Score:2.85|P-value:9.78E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-3.00|P-value:4.84E-4 ID:SGTC_3191|Compound:9110352|FD-Score:2.98|P-value:6.02E-4 ID:SGTC_3233|Compound:9132340|FD-Score:-3.04|P-value:4.14E-4 ID:SGTC_3246|Compound:9135460|FD-Score:3.01|P-value:5.40E-4 ID:SGTC_3250|Compound:9135583|FD-Score:3.04|P-value:4.86E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-3.51|P-value:5.83E-5 ID:SGTC_3281|Compound:9140613|FD-Score:-3.51|P-value:5.84E-5 ID:SGTC_3302|Compound:9125395|FD-Score:3.48|P-value:7.90E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.27|P-value:1.93E-4

Top fitness defect scores for YNL220W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2367 9070478 5.77 135.4 µM 1.62E-10 cell wall 11 3.95E-9
2 SGTC_2514 salinomycin 5.12 42.7 µM 1.25E-8 21 1.54E-7
3 SGTC_2359 9039622 4.96 200.0 µM 3.22E-8 endomembrane recycling 7 3.44E-7
4 SGTC_2316 5844804 4.48 197.4 µM 5.27E-7 14 3.65E-6
5 SGTC_2537 larixol 4.47 68.9 µM 5.69E-7 15 3.90E-6
6 SGTC_2625 euphol 4.33 100.0 µM 1.21E-6 23 7.39E-6
7 SGTC_2386 9075165 4.22 157.4 µM 2.19E-6 6 1.22E-5
8 SGTC_1587 estradiol valerate 4.11 56.1 µM 3.79E-6 9 1.94E-5
9 SGTC_1563 conessine 3.64 56.1 µM 3.78E-5 23 1.36E-4
10 SGTC_1376 2910-0861 3.57 41.3 µM 5.10E-5 31 1.76E-4
11 SGTC_2372 9071633 3.49 200.0 µM 7.46E-5 20 2.43E-4
12 SGTC_3302 9125395 3.48 16.4 µM 7.90E-5 27 2.55E-4
13 SGTC_52 0329-0193 3.47 875.0 nM 8.18E-5 TSC3-RPN4 53 2.63E-4
14 SGTC_3003 9075612 3.42 71.4 µM 9.94E-5 34 3.10E-4
15 SGTC_2894 9048625 3.40 32.5 µM 1.11E-4 28 3.41E-4
16 SGTC_2891 9063876 3.32 19.5 µM 1.53E-4 16 4.48E-4
17 SGTC_701 4424-0219 3.31 185.0 µM 1.63E-4 calcium & mitochondrial duress 35 4.73E-4
18 SGTC_3344 9148862 3.27 3.9 µM 1.93E-4 31 5.45E-4
19 SGTC_2284 7945075 3.21 39.2 µM 2.39E-4 mitochondrial processes 55 6.54E-4
20 SGTC_2239 6685329 3.19 187.6 µM 2.61E-4 68 7.05E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.322 8.74E-82 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.319 3.68E-80 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.289 1.73E-65 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.224 2.60E-39 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.221 1.71E-38 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.215 2.93E-36 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.213 9.62E-36 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.210 7.81E-35 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.196 2.53E-30 YBR196C-A_p YBR196C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.196 3.00E-30 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.184 4.65E-27 YGL144C ROG1 hom Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.179 1.64E-25 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.179 1.76E-25 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.179 2.09E-25 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.170 6.71E-23 YBL087C RPL23A hom Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication