HIPHOP chemogenomics database
YNL220W / ADE12 
Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YNL220W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.322 | 8.74E-82 | YER066W_p | RRT13_p | hom | Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription |
| 0.319 | 3.68E-80 | YLR395C | COX8 | hom | Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain |
| 0.289 | 1.73E-65 | YGL146C_p | RRT6_p | hom | Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins |
| 0.224 | 2.60E-39 | YOR300W_d | YOR300W_d | hom | Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 |
| 0.221 | 1.71E-38 | YCR102W-A_d | YCR102W-A_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.215 | 2.93E-36 | YGR015C_p | YGR015C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion |
| 0.213 | 9.62E-36 | YEL049W | PAU2 | hom | Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme |
| 0.210 | 7.81E-35 | YJL043W_p | YJL043W_p | hom | Putative protein of unknown function; YJL043W is a non-essential gene |
| 0.196 | 2.53E-30 | YBR196C-A_p | YBR196C-A_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |
| 0.196 | 3.00E-30 | YPR088C | SRP54 | het | Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain |
| 0.184 | 4.65E-27 | YGL144C | ROG1 | hom | Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication |
| 0.179 | 1.64E-25 | YER068W | MOT2 | hom | Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications |
| 0.179 | 1.76E-25 | YNR067C | DSE4 | hom | Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother |
| 0.179 | 2.09E-25 | YER071C_p | TDA2_p | hom | Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele |
| 0.170 | 6.71E-23 | YBL087C | RPL23A | hom | Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication |