HIPHOP chemogenomics database
YNL222W / SSU72 
Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YNL222W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.108 | 3.04E-10 | YJR124C_p | YJR124C_p | hom | Putative protein of unknown function; expression induced under calcium shortage |
| 0.098 | 1.45E-8 | YIR042C_p | YIR042C_p | hom | Putative protein of unknown function; YIR042C is a non-essential gene |
| 0.097 | 1.69E-8 | YIL087C | AIM19 | hom | Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth |
| 0.093 | 6.85E-8 | YBR263W | SHM1 | hom | Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine |
| 0.092 | 9.97E-8 | YJL028W | YJL028W | hom | Protein of unknown function; may interact with ribosomes, based on co-purification experiments |
| 0.090 | 2.02E-7 | YGR216C | GPI1 | het | Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs |
| 0.086 | 6.36E-7 | YKL001C | MET14 | hom | Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism |
| 0.083 | 1.65E-6 | YER053C | PIC2 | hom | Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature |
| 0.080 | 3.75E-6 | YIL130W | ASG1 | hom | Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance |
| 0.078 | 6.66E-6 | YNR054C | ESF2 | het | Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome |
| 0.076 | 9.91E-6 | YBR056W | YBR056W | hom | Putative glycoside hydrolase of the mitochondrial intermembrane space |
| 0.075 | 1.22E-5 | YOL056W | GPM3 | hom | Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event |
| 0.075 | 1.36E-5 | YOR344C | TYE7 | hom | Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression |
| 0.074 | 1.56E-5 | YDR006C | SOK1 | hom | Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 |
| 0.074 | 1.82E-5 | YIL113W | SDP1 | hom | Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock |