HIPHOP chemogenomics database

YNL237W / YTP1

Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL237W / YTP1

Click on Significant Values for Screen Details

Top fitness defect scores for YNL237W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1941	st076221	12.40	61.8 µM	3.11E-23	sphingolipid biosynthesis & PDR1	8	2.01E-35
2	SGTC_2858	9025781	10.90	9.0 µM	1.60E-18	sphingolipid biosynthesis & PDR1	16	4.49E-28
3	SGTC_528	3492-0019	9.35	172.0 µM	4.80E-14	calcium & mitochondrial duress	45	4.25E-21
4	SGTC_2500	5-alpha-androstan-3,17-dione	9.07	61.4 µM	2.60E-13		2	5.91E-20
5	SGTC_1897	st060201	8.64	15.0 µM	3.07E-12	mitochondrial processes	1	2.76E-18
6	SGTC_1687	st020778	7.06	55.4 µM	1.02E-8		86	8.38E-13
7	SGTC_682	0kpi-0099	7.00	17.0 µM	1.32E-8		16	1.24E-12
8	SGTC_3140	9094243	6.84	49.5 µM	2.74E-8		3	3.88E-12
9	SGTC_1193	1488-0126	6.31	41.5 µM	2.74E-7		6	1.38E-10
10	SGTC_1877	wortmannin	6.03	25.0 µM	8.56E-7		46	8.12E-10
11	SGTC_1265	0819-1001	5.91	68.8 µM	1.39E-6		2	1.71E-9
12	SGTC_462	ag-879	5.86	158.0 µM	1.67E-6		6	2.29E-9
13	SGTC_1875	nocodazole	5.81	6.0 µM	2.01E-6	tubulin folding & SWR complex	32	3.04E-9
14	SGTC_913	3487-1245	5.71	167.0 µM	3.01E-6		2	5.70E-9
15	SGTC_1287	0971-0001	5.68	34.6 µM	3.34E-6	sphingolipid biosynthesis & PDR1	23	6.72E-9
16	SGTC_1949	st076024	5.59	69.1 µM	4.66E-6		5	1.12E-8
17	SGTC_2036	5160441	5.54	105.0 µM	5.66E-6	NEO1	47	1.52E-8
18	SGTC_995	3931-2021	5.36	34.6 µM	1.07E-5	RPP1 & pyrimidine depletion	6	4.05E-8
19	SGTC_721	1187-1332	5.31	279.0 µM	1.29E-5	cell wall signaling	4	5.46E-8
20	SGTC_1912	st060209	5.26	90.8 µM	1.56E-5		15	7.30E-8

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.375	1.78E-112	YGR164W_d	YGR164W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.343	1.65E-93	YLR204W	QRI5	hom	Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.307	3.25E-74	YMR031W-A_d	YMR031W-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.292	4.24E-67	YBL079W	NUP170	hom	Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.287	1.97E-64	YLR087C	CSF1	hom	Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.274	8.76E-59	YDR120C	TRM1	hom	tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
0.245	5.15E-47	YLR055C	SPT8	hom	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.223	3.11E-39	YOL050C_d	YOL050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.212	2.11E-35	YJR074W	MOG1	hom	Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.210	8.69E-35	YNL229C	URE2	hom	Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.203	1.06E-32	YDR392W	SPT3	hom	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.197	1.16E-30	YKR093W	PTR2	hom	Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.196	2.47E-30	YPL265W	DIP5	hom	Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress
0.184	6.38E-27	YIL170W	HXT12	hom	Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.178	2.23E-25	YGL013C	PDR1	hom	Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication