YNL261W / ORC5

Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNL261W / ORC5

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:2.75|P-value:6.91E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.77|P-value:6.49E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:2.74|P-value:7.18E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.81|P-value:5.28E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-2.66|P-value:9.88E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-2.85|P-value:4.54E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.81|P-value:4.64E-6 ID:SGTC_297|Compound:0986-0032|FD-Score:3.41|P-value:3.73E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:3.14|P-value:1.31E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.09|P-value:1.66E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.80|P-value:5.00E-6 ID:SGTC_780|Compound:0109-0199|FD-Score:2.69|P-value:8.99E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:2.69|P-value:8.85E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.37|P-value:4.53E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.48|P-value:2.62E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.09|P-value:1.65E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:2.67|P-value:9.65E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:-2.68|P-value:9.08E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.85|P-value:3.79E-6 ID:SGTC_1724|Compound:st037281|FD-Score:3.03|P-value:2.19E-4 ID:SGTC_1728|Compound:st035614|FD-Score:2.78|P-value:6.20E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.24|P-value:4.19E-7 ID:SGTC_1734|Compound:st037168|FD-Score:2.81|P-value:5.48E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.57|P-value:1.70E-5 ID:SGTC_1780|Compound:st038448|FD-Score:2.98|P-value:2.72E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.08|P-value:1.73E-4 ID:SGTC_1827|Compound:berberine|FD-Score:2.68|P-value:9.23E-4 ID:SGTC_1892|Compound:st058411|FD-Score:2.92|P-value:3.45E-4 ID:SGTC_2085|Compound:5307070|FD-Score:2.80|P-value:5.70E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.96|P-value:2.87E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-2.81|P-value:5.27E-4 ID:SGTC_2295|Compound:7971645|FD-Score:2.81|P-value:5.47E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.92|P-value:5.21E-9 ID:SGTC_2334|Compound:9017922|FD-Score:-3.23|P-value:8.61E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-4.48|P-value:9.17E-8 ID:SGTC_2429|Compound:5902844|FD-Score:-3.84|P-value:3.89E-6 ID:SGTC_2432|Compound:5630864|FD-Score:3.38|P-value:4.31E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.13|P-value:1.37E-4 ID:SGTC_3007|Compound:9078383|FD-Score:2.76|P-value:6.74E-4 ID:SGTC_3022|Compound:9087993|FD-Score:-2.95|P-value:2.99E-4 ID:SGTC_3036|Compound:9090181|FD-Score:-3.04|P-value:1.96E-4 ID:SGTC_3089|Compound:9117425|FD-Score:2.98|P-value:2.66E-4 ID:SGTC_3090|Compound:9117696|FD-Score:4.53|P-value:6.81E-8 ID:SGTC_3092|Compound:9117248|FD-Score:-2.71|P-value:7.85E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.32|P-value:2.64E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-3.01|P-value:2.29E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-2.83|P-value:4.83E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:2.75|P-value:6.91E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:2.77|P-value:6.49E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:2.74|P-value:7.18E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.81|P-value:5.28E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:-2.66|P-value:9.88E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-2.85|P-value:4.54E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.81|P-value:4.64E-6 ID:SGTC_297|Compound:0986-0032|FD-Score:3.41|P-value:3.73E-5 ID:SGTC_360|Compound:0957-0399|FD-Score:3.14|P-value:1.31E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.09|P-value:1.66E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.80|P-value:5.00E-6 ID:SGTC_780|Compound:0109-0199|FD-Score:2.69|P-value:8.99E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:2.69|P-value:8.85E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.37|P-value:4.53E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.48|P-value:2.62E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.09|P-value:1.65E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:2.67|P-value:9.65E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:-2.68|P-value:9.08E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.85|P-value:3.79E-6 ID:SGTC_1724|Compound:st037281|FD-Score:3.03|P-value:2.19E-4 ID:SGTC_1728|Compound:st035614|FD-Score:2.78|P-value:6.20E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.24|P-value:4.19E-7 ID:SGTC_1734|Compound:st037168|FD-Score:2.81|P-value:5.48E-4 ID:SGTC_1778|Compound:st046819|FD-Score:3.57|P-value:1.70E-5 ID:SGTC_1780|Compound:st038448|FD-Score:2.98|P-value:2.72E-4 ID:SGTC_1794|Compound:st048918|FD-Score:3.08|P-value:1.73E-4 ID:SGTC_1827|Compound:berberine|FD-Score:2.68|P-value:9.23E-4 ID:SGTC_1892|Compound:st058411|FD-Score:2.92|P-value:3.45E-4 ID:SGTC_2085|Compound:5307070|FD-Score:2.80|P-value:5.70E-4 ID:SGTC_2103|Compound:5378138|FD-Score:2.96|P-value:2.87E-4 ID:SGTC_2272|Compound:7805186|FD-Score:-2.81|P-value:5.27E-4 ID:SGTC_2295|Compound:7971645|FD-Score:2.81|P-value:5.47E-4 ID:SGTC_2331|Compound:7980721|FD-Score:4.92|P-value:5.21E-9 ID:SGTC_2334|Compound:9017922|FD-Score:-3.23|P-value:8.61E-5 ID:SGTC_2427|Compound:5545055|FD-Score:-4.48|P-value:9.17E-8 ID:SGTC_2429|Compound:5902844|FD-Score:-3.84|P-value:3.89E-6 ID:SGTC_2432|Compound:5630864|FD-Score:3.38|P-value:4.31E-5 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:3.13|P-value:1.37E-4 ID:SGTC_3007|Compound:9078383|FD-Score:2.76|P-value:6.74E-4 ID:SGTC_3022|Compound:9087993|FD-Score:-2.95|P-value:2.99E-4 ID:SGTC_3036|Compound:9090181|FD-Score:-3.04|P-value:1.96E-4 ID:SGTC_3089|Compound:9117425|FD-Score:2.98|P-value:2.66E-4 ID:SGTC_3090|Compound:9117696|FD-Score:4.53|P-value:6.81E-8 ID:SGTC_3092|Compound:9117248|FD-Score:-2.71|P-value:7.85E-4 ID:SGTC_3205|Compound:9113483|FD-Score:4.32|P-value:2.64E-7 ID:SGTC_3206|Compound:9114350|FD-Score:-3.01|P-value:2.29E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-2.83|P-value:4.83E-4

Top fitness defect scores for YNL261W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2331 7980721 4.92 200.0 µM 5.21E-9 8 4.24E-7 0.40
2 SGTC_3090 9117696 4.53 49.5 µM 6.81E-8 1 2.89E-6 0.72
3 SGTC_3205 9113483 4.32 49.5 µM 2.64E-7 4 7.97E-6 0.10
4 SGTC_1729 st035615 4.24 46.0 µM 4.19E-7 7 1.13E-5 0.01
5 SGTC_1435 4092-0789 3.85 56.7 µM 3.79E-6 plasma membrane duress 5 5.86E-5 0.19
6 SGTC_255 tunicamycin 3.81 200.5 nM 4.64E-6 unfolded protein response 15 6.81E-5 0.10
7 SGTC_519 k048-0011 3.80 62.8 µM 5.00E-6 9 7.21E-5 0.10
8 SGTC_1778 st046819 3.57 58.9 µM 1.70E-5 7 1.81E-4 0.14
9 SGTC_1043 0916-0009 3.48 19.3 µM 2.62E-5 9 2.50E-4 0.09
10 SGTC_297 0986-0032 3.41 24.0 µM 3.73E-5 60S ribosome export 6 3.27E-4 0.01
11 SGTC_2432 5630864 3.38 12.2 µM 4.31E-5 13 3.64E-4 0.03
12 SGTC_1009 4106-0057 3.37 9.9 µM 4.53E-5 14 3.78E-4 0.01
13 SGTC_360 0957-0399 3.14 1.0 µM 1.31E-4 cell wall 22 8.39E-4 0.01
14 SGTC_2574 2',4'-dihydroxychalcone 3.13 14.6 µM 1.37E-4 22 8.70E-4 0.01
15 SGTC_1167 k781-0610 3.09 148.0 µM 1.65E-4 RNA processing & uracil transport 20 9.99E-4 0.03
16 SGTC_362 0310-0100 3.09 9.0 µM 1.66E-4 RPP1 & pyrimidine depletion 18 0.00101 0.02
17 SGTC_1794 st048918 3.08 76.9 µM 1.73E-4 6 0.00104 0.08
18 SGTC_1724 st037281 3.03 8.3 µM 2.19E-4 28 0.00124 0.07
19 SGTC_3089 9117425 2.98 49.5 µM 2.66E-4 9 0.00143 0.11
20 SGTC_1780 st038448 2.98 24.5 µM 2.72E-4 iron homeostasis 16 0.00146 0.04

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 1.65E-20 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.130 4.41E-14 YDL237W AIM6 hom Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene
0.121 1.70E-12 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.115 2.80E-11 YER001W MNN1 hom Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.111 9.94E-11 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.108 3.03E-10 YDR409W SIZ1 hom SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring
0.107 6.10E-10 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.105 1.26E-9 YMR155W_p YMR155W_p hom Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
0.102 2.65E-9 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.101 4.87E-9 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.098 1.17E-8 YER183C FAU1 hom 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
0.094 4.98E-8 YOR005C DNL4 hom DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
0.093 5.87E-8 YLR011W LOT6 hom FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions
0.091 1.22E-7 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.090 1.65E-7 YFR014C CMK1 hom Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication