YNL266W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL266W / YNL266W

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:3.57|P-value:4.60E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.12|P-value:3.04E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.84|P-value:8.91E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.17|P-value:2.62E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.29|P-value:1.61E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.16|P-value:2.56E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.12|P-value:3.00E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.04|P-value:4.42E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.25|P-value:1.89E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:2.84|P-value:9.35E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:2.94|P-value:6.49E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.73|P-value:2.25E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.40|P-value:7.20E-7 ID:SGTC_1558|Compound:st069300|FD-Score:4.74|P-value:1.03E-7 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-2.95|P-value:6.00E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-2.86|P-value:8.26E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:2.83|P-value:9.72E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-2.88|P-value:7.70E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.42|P-value:8.93E-5 ID:SGTC_1851|Compound:st056236|FD-Score:4.61|P-value:2.22E-7 ID:SGTC_1972|Compound:st070201|FD-Score:3.17|P-value:2.58E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.05|P-value:4.20E-4 ID:SGTC_2015|Compound:5119600|FD-Score:4.07|P-value:4.12E-6 ID:SGTC_2016|Compound:5121758|FD-Score:-3.23|P-value:1.95E-4 ID:SGTC_2040|Compound:5100729|FD-Score:-3.85|P-value:1.18E-5 ID:SGTC_2055|Compound:5235184|FD-Score:2.88|P-value:8.12E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.13|P-value:3.14E-6 ID:SGTC_2171|Compound:5739187|FD-Score:3.89|P-value:1.05E-5 ID:SGTC_2175|Compound:5807670|FD-Score:3.05|P-value:4.25E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.05|P-value:4.26E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.33|P-value:1.29E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.23|P-value:2.05E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.45|P-value:7.55E-5 ID:SGTC_2437|Compound:5741531|FD-Score:5.28|P-value:3.75E-9 ID:SGTC_2472|Compound:5377652|FD-Score:4.09|P-value:3.72E-6 ID:SGTC_2570|Compound:licareol|FD-Score:2.86|P-value:8.89E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.30|P-value:1.52E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.56|P-value:4.81E-5 ID:SGTC_2804|Compound:7954240|FD-Score:-3.62|P-value:3.57E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.18|P-value:2.52E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.19|P-value:2.34E-4 ID:SGTC_2852|Compound:9023854|FD-Score:5.28|P-value:3.69E-9 ID:SGTC_2859|Compound:9028643|FD-Score:4.17|P-value:2.48E-6 ID:SGTC_2910|Compound:7948405|FD-Score:5.17|P-value:7.38E-9 ID:SGTC_2953|Compound:9074162|FD-Score:3.30|P-value:1.54E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.63|P-value:3.62E-5 ID:SGTC_3027|Compound:9089541|FD-Score:2.99|P-value:5.38E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.07|P-value:3.94E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:3.57|P-value:4.60E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.12|P-value:3.04E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-2.84|P-value:8.91E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.17|P-value:2.62E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.29|P-value:1.61E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:-3.16|P-value:2.56E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:-3.12|P-value:3.00E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.04|P-value:4.42E-4 ID:SGTC_1363|Compound:1636-0063|FD-Score:3.25|P-value:1.89E-4 ID:SGTC_1432|Compound:4049-0298|FD-Score:2.84|P-value:9.35E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:2.94|P-value:6.49E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.73|P-value:2.25E-5 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:4.40|P-value:7.20E-7 ID:SGTC_1558|Compound:st069300|FD-Score:4.74|P-value:1.03E-7 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-2.95|P-value:6.00E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:-2.86|P-value:8.26E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:2.83|P-value:9.72E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-2.88|P-value:7.70E-4 ID:SGTC_1742|Compound:st038235|FD-Score:3.42|P-value:8.93E-5 ID:SGTC_1851|Compound:st056236|FD-Score:4.61|P-value:2.22E-7 ID:SGTC_1972|Compound:st070201|FD-Score:3.17|P-value:2.58E-4 ID:SGTC_2014|Compound:4013930|FD-Score:3.05|P-value:4.20E-4 ID:SGTC_2015|Compound:5119600|FD-Score:4.07|P-value:4.12E-6 ID:SGTC_2016|Compound:5121758|FD-Score:-3.23|P-value:1.95E-4 ID:SGTC_2040|Compound:5100729|FD-Score:-3.85|P-value:1.18E-5 ID:SGTC_2055|Compound:5235184|FD-Score:2.88|P-value:8.12E-4 ID:SGTC_2060|Compound:5238662|FD-Score:4.13|P-value:3.14E-6 ID:SGTC_2171|Compound:5739187|FD-Score:3.89|P-value:1.05E-5 ID:SGTC_2175|Compound:5807670|FD-Score:3.05|P-value:4.25E-4 ID:SGTC_2259|Compound:7964009|FD-Score:3.05|P-value:4.26E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-3.33|P-value:1.29E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.23|P-value:2.05E-4 ID:SGTC_2402|Compound:5553605|FD-Score:-3.45|P-value:7.55E-5 ID:SGTC_2437|Compound:5741531|FD-Score:5.28|P-value:3.75E-9 ID:SGTC_2472|Compound:5377652|FD-Score:4.09|P-value:3.72E-6 ID:SGTC_2570|Compound:licareol|FD-Score:2.86|P-value:8.89E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.30|P-value:1.52E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.56|P-value:4.81E-5 ID:SGTC_2804|Compound:7954240|FD-Score:-3.62|P-value:3.57E-5 ID:SGTC_2812|Compound:7970281|FD-Score:3.18|P-value:2.52E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-3.19|P-value:2.34E-4 ID:SGTC_2852|Compound:9023854|FD-Score:5.28|P-value:3.69E-9 ID:SGTC_2859|Compound:9028643|FD-Score:4.17|P-value:2.48E-6 ID:SGTC_2910|Compound:7948405|FD-Score:5.17|P-value:7.38E-9 ID:SGTC_2953|Compound:9074162|FD-Score:3.30|P-value:1.54E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.63|P-value:3.62E-5 ID:SGTC_3027|Compound:9089541|FD-Score:2.99|P-value:5.38E-4 ID:SGTC_3071|Compound:9117417|FD-Score:3.07|P-value:3.94E-4

Top fitness defect scores for YNL266W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2852 9023854 5.28 52.0 µM 3.69E-9 15 6.50E-8
2 SGTC_2437 5741531 5.28 144.2 µM 3.75E-9 17 6.58E-8
3 SGTC_2910 7948405 5.17 26.0 µM 7.38E-9 plasma membrane duress 11 1.16E-7
4 SGTC_1558 st069300 4.74 45.6 µM 1.03E-7 6 1.05E-6
5 SGTC_1851 st056236 4.61 18.9 µM 2.22E-7 8 2.00E-6
6 SGTC_1552 6-methylflavone 4.40 10.6 µM 7.20E-7 superoxide 8 5.38E-6
7 SGTC_2859 9028643 4.17 45.5 µM 2.48E-6 13 1.52E-5
8 SGTC_2060 5238662 4.13 140.0 µM 3.14E-6 24 1.85E-5
9 SGTC_2472 5377652 4.09 49.4 µM 3.72E-6 TRP & mitochondrial translation 51 2.14E-5
10 SGTC_2015 5119600 4.07 184.0 µM 4.12E-6 26 2.33E-5
11 SGTC_2171 5739187 3.89 198.1 µM 1.05E-5 copper-dependent oxidative stress 19 5.09E-5
12 SGTC_1542 7-hydroxy-3'-methoxyflavone 3.73 49.7 µM 2.25E-5 16 9.69E-5
13 SGTC_2989 9073649 3.63 71.4 µM 3.62E-5 53 1.44E-4
14 SGTC_44 0929-0055 3.57 61.2 µM 4.60E-5 42 1.77E-4
15 SGTC_2689 tacrolimus 3.56 100.0 µM 4.81E-5 64 1.83E-4
16 SGTC_1742 st038235 3.42 28.9 µM 8.93E-5 mitochondrial stress 145 3.09E-4
17 SGTC_2636 apigenin dimethyl ether 3.30 100.0 µM 1.52E-4 77 4.84E-4
18 SGTC_2953 9074162 3.30 66.5 µM 1.54E-4 52 4.89E-4
19 SGTC_421 streptovitacin 3.29 30.0 mM 1.61E-4 53 5.09E-4
20 SGTC_1363 1636-0063 3.25 10.4 µM 1.89E-4 Golgi 58 5.82E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.80E-11 YER175C TMT1 hom Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.106 7.71E-10 YOL084W PHM7 hom Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress
0.098 1.16E-8 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
0.096 2.30E-8 YOR016C ERP4 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.094 4.87E-8 YEL008W_d YEL008W_d hom Hypothetical protein predicted to be involved in metabolism
0.085 8.63E-7 YHR152W SPO12 hom Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
0.084 1.02E-6 YBR004C GPI18 het Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
0.083 1.50E-6 YLR035C MLH2 hom Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p
0.081 2.39E-6 YNL275W BOR1 hom Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1
0.078 6.30E-6 YMR178W YMR178W hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress
0.078 6.53E-6 YDR446W ECM11 hom Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
0.076 1.03E-5 YPL048W CAM1 hom Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
0.073 2.03E-5 YPL036W PMA2 hom Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
0.072 3.21E-5 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.070 4.95E-5 YDL199C_p YDL199C_p hom Putative transporter, member of the sugar porter family