YNL268W / LYP1

Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL268W / LYP1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:7.34|P-value:1.68E-13 ID:SGTC_71|Compound:0417-1750|FD-Score:3.24|P-value:6.86E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.70|P-value:1.26E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:4.07|P-value:2.83E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:3.33|P-value:5.03E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.45|P-value:5.33E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.40|P-value:3.29E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.04|P-value:1.05E-9 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.78|P-value:1.08E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:3.32|P-value:5.25E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:6.64|P-value:2.22E-11 ID:SGTC_145|Compound:3737-0113|FD-Score:3.78|P-value:9.45E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.25|P-value:5.54E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:10.00|P-value:1.30E-23 ID:SGTC_431|Compound:k089-0097|FD-Score:3.90|P-value:5.75E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:22.60|P-value:1.24E-112 ID:SGTC_456|Compound:gingerol|FD-Score:-3.60|P-value:1.56E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.15|P-value:2.00E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.24|P-value:6.77E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:7.15|P-value:6.48E-13 ID:SGTC_681|Compound:1642-0006|FD-Score:3.25|P-value:6.61E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:5.27|P-value:9.14E-8 ID:SGTC_769|Compound:0302-0231|FD-Score:3.57|P-value:2.13E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:4.76|P-value:1.22E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:5.37|P-value:5.12E-8 ID:SGTC_848|Compound:0368-0089|FD-Score:4.18|P-value:1.80E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:3.20|P-value:7.90E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.38|P-value:4.24E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.39|P-value:4.11E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.84|P-value:5.97E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.57|P-value:2.33E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.80|P-value:1.02E-6 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.18|P-value:1.79E-5 ID:SGTC_1641|Compound:st009299|FD-Score:3.15|P-value:9.33E-4 ID:SGTC_1656|Compound:st012921|FD-Score:6.45|P-value:7.75E-11 ID:SGTC_1718|Compound:roemerine|FD-Score:8.86|P-value:7.39E-19 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.42|P-value:6.10E-6 ID:SGTC_1808|Compound:st050063|FD-Score:-3.50|P-value:2.26E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-3.43|P-value:2.91E-4 ID:SGTC_1968|Compound:st069590|FD-Score:6.46|P-value:7.70E-11 ID:SGTC_2006|Compound:4011487|FD-Score:3.61|P-value:1.82E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.55|P-value:2.29E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.95|P-value:4.60E-5 ID:SGTC_2092|Compound:5303694|FD-Score:3.52|P-value:2.53E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.94|P-value:4.78E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.49|P-value:2.34E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.55|P-value:2.26E-4 ID:SGTC_2219|Compound:9098279|FD-Score:-3.19|P-value:6.84E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.38|P-value:4.15E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.78|P-value:9.43E-5 ID:SGTC_2380|Compound:9035439|FD-Score:-3.53|P-value:1.98E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.82|P-value:6.51E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.58|P-value:1.63E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.35|P-value:3.94E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.42|P-value:3.67E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.28|P-value:1.16E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:8.49|P-value:1.77E-17 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.57|P-value:3.09E-6 ID:SGTC_2805|Compound:7950783|FD-Score:4.25|P-value:1.31E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.97|P-value:4.27E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.32|P-value:5.19E-4 ID:SGTC_2824|Compound:7998404|FD-Score:3.77|P-value:9.76E-5 ID:SGTC_2882|Compound:9058044|FD-Score:-3.54|P-value:1.90E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.69|P-value:1.69E-6 ID:SGTC_2950|Compound:9072895|FD-Score:-3.59|P-value:1.57E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-4.94|P-value:3.79E-7 ID:SGTC_2968|Compound:9090663|FD-Score:5.06|P-value:2.68E-7 ID:SGTC_2969|Compound:9091408|FD-Score:3.98|P-value:4.17E-5 ID:SGTC_3141|Compound:9094609|FD-Score:5.37|P-value:5.31E-8 ID:SGTC_3142|Compound:9086498|FD-Score:3.48|P-value:2.91E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.39|P-value:4.03E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.55|P-value:2.23E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:7.34|P-value:1.68E-13 ID:SGTC_71|Compound:0417-1750|FD-Score:3.24|P-value:6.86E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.70|P-value:1.26E-4 ID:SGTC_83|Compound:0170-0301|FD-Score:4.07|P-value:2.83E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:3.33|P-value:5.03E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:4.45|P-value:5.33E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:-3.40|P-value:3.29E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.04|P-value:1.05E-9 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:4.78|P-value:1.08E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:3.32|P-value:5.25E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:6.64|P-value:2.22E-11 ID:SGTC_145|Compound:3737-0113|FD-Score:3.78|P-value:9.45E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:-3.25|P-value:5.54E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:10.00|P-value:1.30E-23 ID:SGTC_431|Compound:k089-0097|FD-Score:3.90|P-value:5.75E-5 ID:SGTC_451|Compound:chloral hydrate|FD-Score:22.60|P-value:1.24E-112 ID:SGTC_456|Compound:gingerol|FD-Score:-3.60|P-value:1.56E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:4.15|P-value:2.00E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:3.24|P-value:6.77E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:7.15|P-value:6.48E-13 ID:SGTC_681|Compound:1642-0006|FD-Score:3.25|P-value:6.61E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:5.27|P-value:9.14E-8 ID:SGTC_769|Compound:0302-0231|FD-Score:3.57|P-value:2.13E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:4.76|P-value:1.22E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:5.37|P-value:5.12E-8 ID:SGTC_848|Compound:0368-0089|FD-Score:4.18|P-value:1.80E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:3.20|P-value:7.90E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:3.38|P-value:4.24E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:3.39|P-value:4.11E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.84|P-value:5.97E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.57|P-value:2.33E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.80|P-value:1.02E-6 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.18|P-value:1.79E-5 ID:SGTC_1641|Compound:st009299|FD-Score:3.15|P-value:9.33E-4 ID:SGTC_1656|Compound:st012921|FD-Score:6.45|P-value:7.75E-11 ID:SGTC_1718|Compound:roemerine|FD-Score:8.86|P-value:7.39E-19 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:4.42|P-value:6.10E-6 ID:SGTC_1808|Compound:st050063|FD-Score:-3.50|P-value:2.26E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-3.43|P-value:2.91E-4 ID:SGTC_1968|Compound:st069590|FD-Score:6.46|P-value:7.70E-11 ID:SGTC_2006|Compound:4011487|FD-Score:3.61|P-value:1.82E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.55|P-value:2.29E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.95|P-value:4.60E-5 ID:SGTC_2092|Compound:5303694|FD-Score:3.52|P-value:2.53E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.94|P-value:4.78E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.49|P-value:2.34E-4 ID:SGTC_2149|Compound:5554786|FD-Score:3.55|P-value:2.26E-4 ID:SGTC_2219|Compound:9098279|FD-Score:-3.19|P-value:6.84E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.38|P-value:4.15E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.78|P-value:9.43E-5 ID:SGTC_2380|Compound:9035439|FD-Score:-3.53|P-value:1.98E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.82|P-value:6.51E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.58|P-value:1.63E-4 ID:SGTC_2428|Compound:5615643|FD-Score:-3.35|P-value:3.94E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:3.42|P-value:3.67E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.28|P-value:1.16E-5 ID:SGTC_2759|Compound:disulfiram|FD-Score:8.49|P-value:1.77E-17 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.57|P-value:3.09E-6 ID:SGTC_2805|Compound:7950783|FD-Score:4.25|P-value:1.31E-5 ID:SGTC_2811|Compound:7967822|FD-Score:3.97|P-value:4.27E-5 ID:SGTC_2814|Compound:7977482|FD-Score:3.32|P-value:5.19E-4 ID:SGTC_2824|Compound:7998404|FD-Score:3.77|P-value:9.76E-5 ID:SGTC_2882|Compound:9058044|FD-Score:-3.54|P-value:1.90E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.69|P-value:1.69E-6 ID:SGTC_2950|Compound:9072895|FD-Score:-3.59|P-value:1.57E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-4.94|P-value:3.79E-7 ID:SGTC_2968|Compound:9090663|FD-Score:5.06|P-value:2.68E-7 ID:SGTC_2969|Compound:9091408|FD-Score:3.98|P-value:4.17E-5 ID:SGTC_3141|Compound:9094609|FD-Score:5.37|P-value:5.31E-8 ID:SGTC_3142|Compound:9086498|FD-Score:3.48|P-value:2.91E-4 ID:SGTC_3155|Compound:9099265|FD-Score:3.39|P-value:4.03E-4 ID:SGTC_3181|Compound:9108277|FD-Score:3.55|P-value:2.23E-4

Top fitness defect scores for YNL268W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_451 chloral hydrate 22.60 100.0 µM 1.24E-112 1 7.08E-114
2 SGTC_359 0081-0058 10.00 15.9 µM 1.30E-23 60S ribosome export 3 6.40E-24
3 SGTC_1718 roemerine 8.86 11.9 µM 7.39E-19 redox potentiating 3 4.14E-19
4 SGTC_2759 disulfiram 8.49 3.4 µM 1.77E-17 2 1.03E-17
5 SGTC_3 0833-0587 7.34 95.6 µM 1.68E-13 redox potentiating 4 1.09E-13
6 SGTC_674 0498-0004 7.15 451.0 µM 6.48E-13 heme requiring 2 4.27E-13
7 SGTC_123 0083-0120 6.64 66.7 µM 2.22E-11 16 1.53E-11
8 SGTC_1968 st069590 6.46 43.6 µM 7.70E-11 1 5.38E-11
9 SGTC_1656 st012921 6.45 11.0 µM 7.75E-11 14 5.42E-11
10 SGTC_103 0844-0104 6.04 51.8 µM 1.05E-9 ERAD & cell cycle 76 7.62E-10
11 SGTC_824 1304-0008 5.37 100.0 µM 5.12E-8 DNA damage response 14 3.90E-8
12 SGTC_3141 9094609 5.37 49.5 µM 5.31E-8 iron homeostasis 13 4.04E-8
13 SGTC_688 0527-0193 5.27 473.0 µM 9.14E-8 fatty acid desaturase (OLE1) 5 7.01E-8
14 SGTC_2968 9090663 5.06 33.4 µM 2.68E-7 14 2.08E-7
15 SGTC_1240 0356-0016 4.80 42.1 µM 1.02E-6 mitochondrial response to ROS 18 8.07E-7
16 SGTC_120 rhodamine 6G 4.78 52.3 µM 1.08E-6 mitochondrial processes 15 8.56E-7
17 SGTC_818 4072-2707 4.76 53.5 µM 1.22E-6 4 9.71E-7
18 SGTC_2941 9056145 4.69 11.2 µM 1.69E-6 10 1.35E-6
19 SGTC_2778 tioconazole 4.57 65.1 nM 3.09E-6 ergosterol depletion effects on membrane 45 2.48E-6
20 SGTC_95 0471-0001 4.45 561.1 µM 5.33E-6 17 4.32E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.240 2.55E-45 YPL028W ERG10 het Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.217 5.85E-37 YIL039W TED1 hom Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.170 3.82E-23 YBR024W SCO2 hom Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication
0.162 3.28E-21 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.152 7.81E-19 YBR204C LDH1 hom Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)
0.123 6.95E-13 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.123 7.25E-13 YLR153C ACS2 het Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
0.121 1.72E-12 YGL068W MNP1 het Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
0.120 3.10E-12 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.115 3.16E-11 YMR088C VBA1 hom Permease of basic amino acids in the vacuolar membrane
0.113 4.67E-11 YAL066W_d YAL066W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.110 1.41E-10 YML081W TDA9 hom DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication
0.110 1.80E-10 YIL017C VID28 hom GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm
0.109 2.60E-10 YMR170C ALD2 hom Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
0.107 4.30E-10 YCR024C-A PMP1 hom Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication