YNL274C / GOR1

Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL274C / GOR1

Click on Significant Values for Screen Details ID:SGTC_303|Compound:1348-1668|FD-Score:3.06|P-value:3.35E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.30|P-value:1.19E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.30|P-value:1.19E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:2.93|P-value:5.53E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.69|P-value:2.02E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.99|P-value:4.46E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.56|P-value:3.73E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.16|P-value:2.23E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:2.91|P-value:6.13E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:-2.80|P-value:8.66E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.32|P-value:1.12E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.20|P-value:1.86E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.43|P-value:6.84E-5 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.12|P-value:2.44E-4 ID:SGTC_1741|Compound:st038134|FD-Score:2.82|P-value:8.56E-4 ID:SGTC_1784|Compound:st039334|FD-Score:2.86|P-value:7.20E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.21|P-value:1.80E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.75|P-value:5.68E-8 ID:SGTC_2031|Compound:5180455|FD-Score:-2.91|P-value:5.73E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.06|P-value:3.13E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.11|P-value:2.49E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.31|P-value:1.06E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-2.80|P-value:8.72E-4 ID:SGTC_2284|Compound:7945075|FD-Score:2.93|P-value:5.59E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.17|P-value:2.14E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.31|P-value:1.16E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.88|P-value:7.34E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.90|P-value:6.43E-6 ID:SGTC_2641|Compound:levomentholum|FD-Score:2.96|P-value:4.99E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.89|P-value:7.24E-6 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.50|P-value:4.84E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:3.32|P-value:1.08E-4 ID:SGTC_2976|Compound:9009005|FD-Score:6.99|P-value:3.39E-15 ID:SGTC_2977|Compound:9011197|FD-Score:5.69|P-value:1.14E-10 ID:SGTC_2978|Compound:9011784|FD-Score:5.69|P-value:1.13E-10 ID:SGTC_2980|Compound:9014342|FD-Score:5.38|P-value:1.04E-9 ID:SGTC_3042|Compound:9091578|FD-Score:3.18|P-value:2.05E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.67|P-value:2.05E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-3.22|P-value:1.58E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.06|P-value:3.35E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:3.30|P-value:1.19E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:3.30|P-value:1.19E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:2.93|P-value:5.53E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.69|P-value:2.02E-5 ID:SGTC_1141|Compound:3253-0389|FD-Score:2.99|P-value:4.46E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.56|P-value:3.73E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.16|P-value:2.23E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:2.91|P-value:6.13E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:-2.80|P-value:8.66E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.32|P-value:1.12E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.20|P-value:1.86E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:3.43|P-value:6.84E-5 ID:SGTC_1440|Compound:4100-1550|FD-Score:-3.12|P-value:2.44E-4 ID:SGTC_1741|Compound:st038134|FD-Score:2.82|P-value:8.56E-4 ID:SGTC_1784|Compound:st039334|FD-Score:2.86|P-value:7.20E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.21|P-value:1.80E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.75|P-value:5.68E-8 ID:SGTC_2031|Compound:5180455|FD-Score:-2.91|P-value:5.73E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-3.06|P-value:3.13E-4 ID:SGTC_2066|Compound:5222451|FD-Score:-3.11|P-value:2.49E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.31|P-value:1.06E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-2.80|P-value:8.72E-4 ID:SGTC_2284|Compound:7945075|FD-Score:2.93|P-value:5.59E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.17|P-value:2.14E-4 ID:SGTC_2449|Compound:5812982|FD-Score:3.31|P-value:1.16E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.88|P-value:7.34E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.90|P-value:6.43E-6 ID:SGTC_2641|Compound:levomentholum|FD-Score:2.96|P-value:4.99E-4 ID:SGTC_2644|Compound:guaiazulene|FD-Score:3.89|P-value:7.24E-6 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.50|P-value:4.84E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:3.32|P-value:1.08E-4 ID:SGTC_2976|Compound:9009005|FD-Score:6.99|P-value:3.39E-15 ID:SGTC_2977|Compound:9011197|FD-Score:5.69|P-value:1.14E-10 ID:SGTC_2978|Compound:9011784|FD-Score:5.69|P-value:1.13E-10 ID:SGTC_2980|Compound:9014342|FD-Score:5.38|P-value:1.04E-9 ID:SGTC_3042|Compound:9091578|FD-Score:3.18|P-value:2.05E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.67|P-value:2.05E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-3.22|P-value:1.58E-4

Top fitness defect scores for YNL274C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2976 9009005 6.99 19.5 µM 3.39E-15 9 1.38E-12
2 SGTC_2978 9011784 5.69 43.0 µM 1.13E-10 8 6.25E-9
3 SGTC_2977 9011197 5.69 71.4 µM 1.14E-10 7 6.26E-9
4 SGTC_2980 9014342 5.38 25.3 µM 1.04E-9 14 3.76E-8
5 SGTC_2644 guaiazulene 3.89 100.0 µM 7.24E-6 4 4.91E-5
6 SGTC_1030 k029-0042 3.69 36.7 µM 2.02E-5 TSC3-RPN4 35 1.13E-4
7 SGTC_1154 4088-0362 3.56 150.0 µM 3.73E-5 34 1.87E-4
8 SGTC_2722 naftopidil 3.50 47.2 µM 4.84E-5 13 2.31E-4
9 SGTC_1376 2910-0861 3.43 41.3 µM 6.84E-5 38 3.06E-4
10 SGTC_2736 butenafine 3.32 14.7 µM 1.08E-4 49 4.45E-4
11 SGTC_1257 0669-0121 3.32 16.0 µM 1.12E-4 52 4.57E-4
12 SGTC_2449 5812982 3.31 45.8 µM 1.16E-4 22 4.71E-4
13 SGTC_326 k292-0812 3.30 17.5 µM 1.19E-4 15 4.80E-4
14 SGTC_565 1418-0001 3.30 44.5 µM 1.19E-4 46 4.81E-4
15 SGTC_1924 st058459 3.21 75.1 µM 1.80E-4 30 6.73E-4
16 SGTC_1311 1190-0148 3.20 100.0 µM 1.86E-4 azole & statin 52 6.91E-4
17 SGTC_3042 9091578 3.18 49.5 µM 2.05E-4 ERG2 19 7.48E-4
18 SGTC_2386 9075165 3.17 157.4 µM 2.14E-4 23 7.74E-4
19 SGTC_1156 4092-0367 3.16 4.9 µM 2.23E-4 63 8.02E-4
20 SGTC_303 1348-1668 3.06 34.2 µM 3.35E-4 20 0.00112

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.176 1.04E-24 YDR340W_d YDR340W_d hom Putative protein of unknown function
0.166 3.46E-22 YGR063C SPT4 hom Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.158 3.41E-20 YDL027C_p YDL027C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
0.157 8.17E-20 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.156 9.68E-20 YGR046W TAM41 het Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition
0.134 6.14E-15 YDR085C AFR1 hom Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication
0.129 5.79E-14 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.121 1.71E-12 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.121 2.05E-12 YBR057C MUM2 hom Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex
0.119 4.76E-12 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.116 1.60E-11 YMR252C_p YMR252C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene
0.116 1.61E-11 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.114 3.92E-11 YLR345W_p YLR345W_p hom Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
0.112 9.53E-11 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.110 1.57E-10 YHR071W PCL5 hom Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity