HIPHOP chemogenomics database

YNL278W / CAF120

Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; CAF120 has a paralog, SKG3, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL278W / CAF120

Click on Significant Values for Screen Details

Top fitness defect scores for YNL278W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2781	5567276	5.43	71.4 µM	1.05E-8		17	2.80E-8
2	SGTC_70	0141-0289	4.71	43.3 µM	5.92E-7	mitochondrial stress	123	1.26E-6
3	SGTC_689	0833-0039	4.35	98.0 µM	3.59E-6	ergosterol depletion effects on membrane	27	6.92E-6
4	SGTC_2069	5228469	4.34	200.0 µM	3.69E-6		8	7.11E-6
5	SGTC_2149	5554786	4.13	194.8 µM	1.01E-5	cell wall signaling	31	1.84E-5
6	SGTC_1955	wogonin	4.01	32.4 µM	1.68E-5		18	2.97E-5
7	SGTC_1217	1183-1422	4.00	255.0 µM	1.79E-5		10	3.16E-5
8	SGTC_2788	5282734	3.93	71.4 µM	2.45E-5		48	4.25E-5
9	SGTC_1031	k035-0009	3.92	16.0 µM	2.50E-5		33	4.34E-5
10	SGTC_178	4092-0806	3.89	87.5 µM	2.98E-5	ergosterol depletion effects on membrane	102	5.11E-5
11	SGTC_602	3130-1533	3.87	38.1 µM	3.25E-5		19	5.55E-5
12	SGTC_1679	4130-1276	3.84	6.7 µM	3.63E-5	Golgi	66	6.16E-5
13	SGTC_71	0417-1750	3.74	47.8 µM	5.56E-5	Golgi	51	9.21E-5
14	SGTC_253	dyclonine	3.60	31.2 µM	9.77E-5	amide catabolism	36	1.57E-4
15	SGTC_1879	gemcitabine	3.53	100.0 µM	1.31E-4		24	2.07E-4
16	SGTC_1893	st059353	3.51	36.1 µM	1.44E-4		39	2.27E-4
17	SGTC_612	0302-0167	3.46	22.4 µM	1.72E-4	copper-dependent oxidative stress	57	2.67E-4
18	SGTC_217	ketoconazole	3.44	989.0 nM	1.88E-4	ergosterol depletion effects on membrane	43	2.91E-4
19	SGTC_2556	citropten	3.44	84.6 µM	1.89E-4		47	2.92E-4
20	SGTC_1040	k898-0338	3.42	155.0 µM	2.05E-4		33	3.16E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.106	7.44E-10	YDR451C	YHP1	hom	Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication
0.101	4.73E-9	YBR102C	EXO84	het	Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
0.098	1.11E-8	YGR289C	MAL11	hom	Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization
0.097	1.92E-8	YMR079W	SEC14	het	Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.092	8.01E-8	YJL078C	PRY3	hom	Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p
0.092	8.68E-8	YML070W	DAK1	hom	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
0.092	8.68E-8	YDR509W_d	YDR509W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087	4.47E-7	YOR204W	DED1	het	ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility
0.085	7.68E-7	YDL226C	GCS1	hom	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.085	8.14E-7	YCL031C	RRP7	het	Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress
0.083	1.56E-6	YNL299W	TRF5	hom	Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p
0.082	2.03E-6	YMR071C	TVP18	hom	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.081	2.95E-6	YHR155W	YSP1	hom	Mitochondrial protein; potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone; YSP1 has a paralog, SIP3, that arose from the whole genome duplication
0.078	5.41E-6	YKR002W	PAP1	het	Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
0.078	5.69E-6	YDR439W	LRS4	hom	Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation