YNL294C / RIM21

pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL294C / RIM21

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.82|P-value:3.41E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.04|P-value:2.28E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:-5.18|P-value:2.24E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:-4.36|P-value:5.61E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:6.22|P-value:1.66E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:8.85|P-value:1.92E-15 ID:SGTC_197|Compound:4544-0043|FD-Score:4.76|P-value:1.15E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:6.99|P-value:2.70E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:5.06|P-value:3.54E-6 ID:SGTC_279|Compound:1273-0055|FD-Score:4.38|P-value:4.88E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.77|P-value:4.28E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.81|P-value:3.54E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:5.56|P-value:3.89E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:7.13|P-value:1.20E-10 ID:SGTC_383|Compound:2324-0395|FD-Score:3.89|P-value:2.72E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.84|P-value:1.18E-7 ID:SGTC_525|Compound:k781-2675|FD-Score:4.34|P-value:5.83E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.04|P-value:1.67E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:4.72|P-value:1.36E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.85|P-value:8.12E-6 ID:SGTC_608|Compound:k048-0125|FD-Score:3.68|P-value:5.29E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.43|P-value:4.18E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:3.62|P-value:6.39E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.27|P-value:7.37E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.50|P-value:9.23E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.26|P-value:7.63E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.28|P-value:7.48E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.50|P-value:9.18E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:11.60|P-value:4.23E-25 ID:SGTC_805|Compound:3852-0218|FD-Score:5.91|P-value:7.79E-8 ID:SGTC_862|Compound:0452-0056|FD-Score:6.38|P-value:7.26E-9 ID:SGTC_902|Compound:1120-0002|FD-Score:3.91|P-value:2.59E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.31|P-value:6.47E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-5.01|P-value:4.64E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.62|P-value:2.06E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.11|P-value:1.30E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:14.00|P-value:8.95E-36 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.09|P-value:3.19E-8 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:7.37|P-value:3.03E-11 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.57|P-value:2.59E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.00|P-value:1.88E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:5.12|P-value:2.71E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:5.28|P-value:1.36E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.73|P-value:1.32E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:10.90|P-value:2.44E-22 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.62|P-value:6.40E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.41|P-value:4.65E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:-4.14|P-value:1.23E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.13|P-value:1.22E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.96|P-value:2.18E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.71|P-value:5.20E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.72|P-value:4.72E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.65|P-value:2.63E-7 ID:SGTC_1712|Compound:st032288|FD-Score:4.50|P-value:3.13E-5 ID:SGTC_1754|Compound:st042065|FD-Score:8.72|P-value:5.00E-15 ID:SGTC_1760|Compound:st045453|FD-Score:8.06|P-value:4.27E-13 ID:SGTC_1781|Compound:st038725|FD-Score:3.65|P-value:5.81E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:13.10|P-value:2.43E-31 ID:SGTC_1797|Compound:st048695|FD-Score:7.28|P-value:5.03E-11 ID:SGTC_1800|Compound:st050079|FD-Score:9.44|P-value:2.70E-17 ID:SGTC_1801|Compound:st050089|FD-Score:13.30|P-value:1.24E-32 ID:SGTC_1803|Compound:st050068|FD-Score:12.50|P-value:4.64E-29 ID:SGTC_1818|Compound:st052136|FD-Score:6.97|P-value:3.01E-10 ID:SGTC_1829|Compound:berberine|FD-Score:4.18|P-value:1.00E-4 ID:SGTC_1884|Compound:5633444|FD-Score:7.75|P-value:2.90E-12 ID:SGTC_1888|Compound:azatryptophan|FD-Score:5.09|P-value:3.03E-6 ID:SGTC_1904|Compound:st060225|FD-Score:3.67|P-value:5.45E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-4.79|P-value:1.11E-5 ID:SGTC_1950|Compound:st077106|FD-Score:-3.64|P-value:6.44E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.17|P-value:1.05E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.50|P-value:3.16E-5 ID:SGTC_2021|Compound:4019055|FD-Score:11.90|P-value:3.25E-26 ID:SGTC_2036|Compound:5160441|FD-Score:4.96|P-value:5.28E-6 ID:SGTC_2038|Compound:4100038|FD-Score:3.75|P-value:4.22E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.60|P-value:6.87E-4 ID:SGTC_2136|Compound:5328288|FD-Score:4.24|P-value:8.13E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.53|P-value:4.53E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.52|P-value:4.64E-7 ID:SGTC_2284|Compound:7945075|FD-Score:-3.87|P-value:3.07E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.90|P-value:6.70E-6 ID:SGTC_2322|Compound:7413319|FD-Score:8.24|P-value:1.29E-13 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.02|P-value:1.75E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.79|P-value:3.81E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.47|P-value:3.52E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.74|P-value:1.74E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.65|P-value:6.24E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:9.81|P-value:1.59E-18 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.86|P-value:7.90E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.14|P-value:1.25E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.95|P-value:3.41E-10 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.20|P-value:1.93E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:4.73|P-value:1.32E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.56|P-value:3.99E-7 ID:SGTC_2776|Compound:terbinafine|FD-Score:6.16|P-value:2.19E-8 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.55|P-value:2.64E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.25|P-value:7.88E-5 ID:SGTC_2816|Compound:7982706|FD-Score:3.94|P-value:2.28E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.93|P-value:2.39E-4 ID:SGTC_2928|Compound:9011484|FD-Score:6.06|P-value:3.60E-8 ID:SGTC_3018|Compound:9082602|FD-Score:5.39|P-value:8.57E-7 ID:SGTC_3037|Compound:9091026|FD-Score:11.80|P-value:6.73E-26 ID:SGTC_3066|Compound:9117245|FD-Score:3.59|P-value:7.11E-4 ID:SGTC_3082|Compound:9117008|FD-Score:4.90|P-value:6.65E-6 ID:SGTC_3098|Compound:9119039|FD-Score:5.69|P-value:2.16E-7 ID:SGTC_3142|Compound:9086498|FD-Score:-5.30|P-value:1.32E-6 ID:SGTC_3152|Compound:9099253|FD-Score:9.78|P-value:2.02E-18 ID:SGTC_3296|Compound:9122258|FD-Score:6.36|P-value:7.96E-9 ID:SGTC_3308|Compound:9128332|FD-Score:4.48|P-value:3.43E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:3.82|P-value:3.41E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.04|P-value:2.28E-10 ID:SGTC_59|Compound:0330-0160|FD-Score:-5.18|P-value:2.24E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:-4.36|P-value:5.61E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:6.22|P-value:1.66E-8 ID:SGTC_178|Compound:4092-0806|FD-Score:8.85|P-value:1.92E-15 ID:SGTC_197|Compound:4544-0043|FD-Score:4.76|P-value:1.15E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:6.99|P-value:2.70E-10 ID:SGTC_227|Compound:fluconazole|FD-Score:5.06|P-value:3.54E-6 ID:SGTC_279|Compound:1273-0055|FD-Score:4.38|P-value:4.88E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:-3.77|P-value:4.28E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.81|P-value:3.54E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:5.56|P-value:3.89E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:7.13|P-value:1.20E-10 ID:SGTC_383|Compound:2324-0395|FD-Score:3.89|P-value:2.72E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.84|P-value:1.18E-7 ID:SGTC_525|Compound:k781-2675|FD-Score:4.34|P-value:5.83E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.04|P-value:1.67E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:4.72|P-value:1.36E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.85|P-value:8.12E-6 ID:SGTC_608|Compound:k048-0125|FD-Score:3.68|P-value:5.29E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.43|P-value:4.18E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:3.62|P-value:6.39E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.27|P-value:7.37E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.50|P-value:9.23E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:4.26|P-value:7.63E-5 ID:SGTC_783|Compound:0848-0141|FD-Score:-4.28|P-value:7.48E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.50|P-value:9.18E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:11.60|P-value:4.23E-25 ID:SGTC_805|Compound:3852-0218|FD-Score:5.91|P-value:7.79E-8 ID:SGTC_862|Compound:0452-0056|FD-Score:6.38|P-value:7.26E-9 ID:SGTC_902|Compound:1120-0002|FD-Score:3.91|P-value:2.59E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.31|P-value:6.47E-5 ID:SGTC_1027|Compound:k015-0025|FD-Score:-5.01|P-value:4.64E-6 ID:SGTC_1036|Compound:k216-0215|FD-Score:4.62|P-value:2.06E-5 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.11|P-value:1.30E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:14.00|P-value:8.95E-36 ID:SGTC_1067|Compound:clotrimazole|FD-Score:6.09|P-value:3.19E-8 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:7.37|P-value:3.03E-11 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.57|P-value:2.59E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.00|P-value:1.88E-4 ID:SGTC_1174|Compound:0739-0097|FD-Score:5.12|P-value:2.71E-6 ID:SGTC_1191|Compound:1487-1166|FD-Score:5.28|P-value:1.36E-6 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.73|P-value:1.32E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:10.90|P-value:2.44E-22 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.62|P-value:6.40E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.41|P-value:4.65E-5 ID:SGTC_1377|Compound:2944-0135|FD-Score:-4.14|P-value:1.23E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.13|P-value:1.22E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.96|P-value:2.18E-4 ID:SGTC_1574|Compound:spiramycin|FD-Score:-3.71|P-value:5.20E-4 ID:SGTC_1638|Compound:st008370|FD-Score:3.72|P-value:4.72E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.65|P-value:2.63E-7 ID:SGTC_1712|Compound:st032288|FD-Score:4.50|P-value:3.13E-5 ID:SGTC_1754|Compound:st042065|FD-Score:8.72|P-value:5.00E-15 ID:SGTC_1760|Compound:st045453|FD-Score:8.06|P-value:4.27E-13 ID:SGTC_1781|Compound:st038725|FD-Score:3.65|P-value:5.81E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:13.10|P-value:2.43E-31 ID:SGTC_1797|Compound:st048695|FD-Score:7.28|P-value:5.03E-11 ID:SGTC_1800|Compound:st050079|FD-Score:9.44|P-value:2.70E-17 ID:SGTC_1801|Compound:st050089|FD-Score:13.30|P-value:1.24E-32 ID:SGTC_1803|Compound:st050068|FD-Score:12.50|P-value:4.64E-29 ID:SGTC_1818|Compound:st052136|FD-Score:6.97|P-value:3.01E-10 ID:SGTC_1829|Compound:berberine|FD-Score:4.18|P-value:1.00E-4 ID:SGTC_1884|Compound:5633444|FD-Score:7.75|P-value:2.90E-12 ID:SGTC_1888|Compound:azatryptophan|FD-Score:5.09|P-value:3.03E-6 ID:SGTC_1904|Compound:st060225|FD-Score:3.67|P-value:5.45E-4 ID:SGTC_1944|Compound:st076371|FD-Score:-4.79|P-value:1.11E-5 ID:SGTC_1950|Compound:st077106|FD-Score:-3.64|P-value:6.44E-4 ID:SGTC_1952|Compound:st077036|FD-Score:4.17|P-value:1.05E-4 ID:SGTC_2016|Compound:5121758|FD-Score:4.50|P-value:3.16E-5 ID:SGTC_2021|Compound:4019055|FD-Score:11.90|P-value:3.25E-26 ID:SGTC_2036|Compound:5160441|FD-Score:4.96|P-value:5.28E-6 ID:SGTC_2038|Compound:4100038|FD-Score:3.75|P-value:4.22E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.60|P-value:6.87E-4 ID:SGTC_2136|Compound:5328288|FD-Score:4.24|P-value:8.13E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.53|P-value:4.53E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.52|P-value:4.64E-7 ID:SGTC_2284|Compound:7945075|FD-Score:-3.87|P-value:3.07E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.90|P-value:6.70E-6 ID:SGTC_2322|Compound:7413319|FD-Score:8.24|P-value:1.29E-13 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.02|P-value:1.75E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.79|P-value:3.81E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.47|P-value:3.52E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.74|P-value:1.74E-7 ID:SGTC_2589|Compound:lobaric acid|FD-Score:-3.65|P-value:6.24E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:9.81|P-value:1.59E-18 ID:SGTC_2648|Compound:atorvastatin|FD-Score:4.86|P-value:7.90E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.14|P-value:1.25E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.95|P-value:3.41E-10 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.20|P-value:1.93E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:4.73|P-value:1.32E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:5.56|P-value:3.99E-7 ID:SGTC_2776|Compound:terbinafine|FD-Score:6.16|P-value:2.19E-8 ID:SGTC_2778|Compound:tioconazole|FD-Score:4.55|P-value:2.64E-5 ID:SGTC_2790|Compound:5423970|FD-Score:4.25|P-value:7.88E-5 ID:SGTC_2816|Compound:7982706|FD-Score:3.94|P-value:2.28E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.93|P-value:2.39E-4 ID:SGTC_2928|Compound:9011484|FD-Score:6.06|P-value:3.60E-8 ID:SGTC_3018|Compound:9082602|FD-Score:5.39|P-value:8.57E-7 ID:SGTC_3037|Compound:9091026|FD-Score:11.80|P-value:6.73E-26 ID:SGTC_3066|Compound:9117245|FD-Score:3.59|P-value:7.11E-4 ID:SGTC_3082|Compound:9117008|FD-Score:4.90|P-value:6.65E-6 ID:SGTC_3098|Compound:9119039|FD-Score:5.69|P-value:2.16E-7 ID:SGTC_3142|Compound:9086498|FD-Score:-5.30|P-value:1.32E-6 ID:SGTC_3152|Compound:9099253|FD-Score:9.78|P-value:2.02E-18 ID:SGTC_3296|Compound:9122258|FD-Score:6.36|P-value:7.96E-9 ID:SGTC_3308|Compound:9128332|FD-Score:4.48|P-value:3.43E-5

Top fitness defect scores for YNL294C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1044 1222-0021 14.00 1.8 µM 8.95E-36 heme biosynthesis & mitochondrial translocase 2 7.10E-45
2 SGTC_1801 st050089 13.30 28.4 µM 1.24E-32 NEO1-PIK1 3 6.86E-41
3 SGTC_1788 fluconazole 13.10 20.0 µM 2.43E-31 azole & statin 6 3.00E-39
4 SGTC_1803 st050068 12.50 52.4 µM 4.64E-29 NEO1-PIK1 11 2.34E-36
5 SGTC_2021 4019055 11.90 173.0 µM 3.25E-26 endomembrane recycling 4 9.51E-33
6 SGTC_3037 9091026 11.80 49.5 µM 6.73E-26 NEO1-PIK1 2 2.39E-32
7 SGTC_788 1182-0090 11.60 188.0 µM 4.23E-25 endomembrane recycling 10 2.46E-31
8 SGTC_1317 1273-0028 10.90 910.0 nM 2.44E-22 azole & statin 12 7.80E-28
9 SGTC_2619 obliquin 9.81 87.9 µM 1.59E-18 cell wall 22 5.28E-23
10 SGTC_3152 9099253 9.78 49.5 µM 2.02E-18 NEO1-PIK1 27 7.18E-23
11 SGTC_1800 st050079 9.44 29.1 µM 2.70E-17 NEO1-PIK1 6 1.91E-21
12 SGTC_178 4092-0806 8.85 87.5 µM 1.92E-15 ergosterol depletion effects on membrane 15 4.23E-19
13 SGTC_1754 st042065 8.72 16.1 µM 5.00E-15 NEO1-PIK1 45 1.42E-18
14 SGTC_2322 7413319 8.24 38.2 µM 1.29E-13 ERAD & cell cycle 32 8.71E-17
15 SGTC_1760 st045453 8.06 10.4 µM 4.27E-13 NEO1-PIK1 53 3.96E-16
16 SGTC_1884 5633444 7.75 25.0 µM 2.90E-12 redox potentiating 20 4.47E-15
17 SGTC_1083 didemethylchlorpromazine sulfoxide 7.37 707.4 nM 3.03E-11 redox potentiating 16 8.67E-14
18 SGTC_1797 st048695 7.28 56.8 µM 5.03E-11 NEO1 28 1.65E-13
19 SGTC_363 0455-0021 7.13 3.1 µM 1.20E-10 azole & statin 21 4.93E-13
20 SGTC_206 4546-0025 6.99 72.0 µM 2.70E-10 NEO1 27 1.38E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.586 2.06E-308 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.585 3.22E-306 YMR154C RIM13 hom Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB
0.568 9.97E-286 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.553 3.57E-268 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.542 4.10E-255 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.504 1.24E-215 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.448 1.04E-164 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.390 6.58E-122 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.387 4.00E-120 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.383 8.15E-118 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.370 4.28E-109 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.348 3.14E-96 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.344 3.03E-93 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.337 6.97E-90 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.336 1.69E-89 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family