YNL295W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL295W / YNL295W

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-3.34|P-value:1.65E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.02|P-value:6.04E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.22|P-value:2.04E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:21.60|P-value:4.22E-122 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.17|P-value:2.50E-4 ID:SGTC_223|Compound:busulfan|FD-Score:-3.53|P-value:7.38E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:-2.89|P-value:9.68E-4 ID:SGTC_232|Compound:clozapine|FD-Score:6.39|P-value:1.39E-12 ID:SGTC_245|Compound:methotrexate|FD-Score:3.87|P-value:1.08E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:3.27|P-value:1.63E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.98|P-value:2.52E-8 ID:SGTC_357|Compound:1325-0123|FD-Score:4.28|P-value:1.34E-6 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.43|P-value:1.11E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.12|P-value:4.04E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.22|P-value:2.03E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.58|P-value:4.18E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:3.54|P-value:5.02E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.93|P-value:6.36E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:2.93|P-value:6.36E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.56|P-value:4.69E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-2.95|P-value:7.75E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.01|P-value:6.20E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-4.91|P-value:5.97E-8 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.86|P-value:7.75E-8 ID:SGTC_1214|Compound:0358-0031|FD-Score:-5.57|P-value:8.87E-10 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.78|P-value:1.67E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.68|P-value:2.22E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.79|P-value:1.23E-7 ID:SGTC_1620|Compound:st003704|FD-Score:2.95|P-value:5.82E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.51|P-value:7.98E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.61|P-value:3.42E-7 ID:SGTC_1683|Compound:st010134|FD-Score:-3.32|P-value:1.77E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.80|P-value:7.55E-8 ID:SGTC_2107|Compound:5363541|FD-Score:3.84|P-value:1.26E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.52|P-value:7.78E-5 ID:SGTC_2309|Compound:7664088|FD-Score:2.85|P-value:8.64E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.33|P-value:1.06E-6 ID:SGTC_2342|Compound:7990637|FD-Score:-3.42|P-value:1.18E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.09|P-value:4.48E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.28|P-value:2.09E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.22|P-value:2.00E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.99|P-value:6.57E-4 ID:SGTC_2602|Compound:kawain|FD-Score:6.03|P-value:2.12E-11 ID:SGTC_2605|Compound:digitonin|FD-Score:3.41|P-value:8.85E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:5.34|P-value:2.61E-9 ID:SGTC_2692|Compound:st077426|FD-Score:3.34|P-value:1.21E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.19|P-value:2.19E-6 ID:SGTC_2903|Compound:5923464|FD-Score:-2.88|P-value:9.93E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.35|P-value:1.56E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-2.90|P-value:9.17E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.07|P-value:4.87E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.34|P-value:1.65E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.02|P-value:6.04E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.22|P-value:2.04E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:21.60|P-value:4.22E-122 ID:SGTC_222|Compound:nsc-310342|FD-Score:3.17|P-value:2.50E-4 ID:SGTC_223|Compound:busulfan|FD-Score:-3.53|P-value:7.38E-5 ID:SGTC_225|Compound:nsc-122657|FD-Score:-2.89|P-value:9.68E-4 ID:SGTC_232|Compound:clozapine|FD-Score:6.39|P-value:1.39E-12 ID:SGTC_245|Compound:methotrexate|FD-Score:3.87|P-value:1.08E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:3.27|P-value:1.63E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:4.98|P-value:2.52E-8 ID:SGTC_357|Compound:1325-0123|FD-Score:4.28|P-value:1.34E-6 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.43|P-value:1.11E-4 ID:SGTC_392|Compound:N-ethylmaleimide|FD-Score:-3.12|P-value:4.04E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.22|P-value:2.03E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.58|P-value:4.18E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:3.54|P-value:5.02E-5 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.93|P-value:6.36E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:2.93|P-value:6.36E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:3.56|P-value:4.69E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-2.95|P-value:7.75E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.01|P-value:6.20E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:-4.91|P-value:5.97E-8 ID:SGTC_1213|Compound:1315-0166|FD-Score:-4.86|P-value:7.75E-8 ID:SGTC_1214|Compound:0358-0031|FD-Score:-5.57|P-value:8.87E-10 ID:SGTC_1222|Compound:0366-0074|FD-Score:3.78|P-value:1.67E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.68|P-value:2.22E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.79|P-value:1.23E-7 ID:SGTC_1620|Compound:st003704|FD-Score:2.95|P-value:5.82E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-3.51|P-value:7.98E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.61|P-value:3.42E-7 ID:SGTC_1683|Compound:st010134|FD-Score:-3.32|P-value:1.77E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.80|P-value:7.55E-8 ID:SGTC_2107|Compound:5363541|FD-Score:3.84|P-value:1.26E-5 ID:SGTC_2293|Compound:7624732|FD-Score:-3.52|P-value:7.78E-5 ID:SGTC_2309|Compound:7664088|FD-Score:2.85|P-value:8.64E-4 ID:SGTC_2341|Compound:7987486|FD-Score:4.33|P-value:1.06E-6 ID:SGTC_2342|Compound:7990637|FD-Score:-3.42|P-value:1.18E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.09|P-value:4.48E-4 ID:SGTC_2475|Compound:5812728|FD-Score:-3.28|P-value:2.09E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.22|P-value:2.00E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-2.99|P-value:6.57E-4 ID:SGTC_2602|Compound:kawain|FD-Score:6.03|P-value:2.12E-11 ID:SGTC_2605|Compound:digitonin|FD-Score:3.41|P-value:8.85E-5 ID:SGTC_2608|Compound:thymoquinone|FD-Score:5.34|P-value:2.61E-9 ID:SGTC_2692|Compound:st077426|FD-Score:3.34|P-value:1.21E-4 ID:SGTC_2693|Compound:st077581|FD-Score:4.19|P-value:2.19E-6 ID:SGTC_2903|Compound:5923464|FD-Score:-2.88|P-value:9.93E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.35|P-value:1.56E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-2.90|P-value:9.17E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.07|P-value:4.87E-4

Top fitness defect scores for YNL295W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_221 trifluoperazine 21.60 10.3 µM 4.22E-122 NEO1-PIK1 9 2.06E-103
2 SGTC_232 clozapine 6.39 119.0 µM 1.39E-12 NEO1 28 8.06E-11
3 SGTC_2602 kawain 6.03 100.0 µM 2.12E-11 2 8.04E-10
4 SGTC_2608 thymoquinone 5.34 42.7 µM 2.61E-9 6 4.71E-8
5 SGTC_343 4130-2827 4.98 29.8 µM 2.52E-8 16 3.20E-7
6 SGTC_1741 st038134 4.80 10.2 µM 7.55E-8 12 8.08E-7
7 SGTC_2341 7987486 4.33 176.7 µM 1.06E-6 12 7.54E-6
8 SGTC_357 1325-0123 4.28 420.0 µM 1.34E-6 3 9.21E-6
9 SGTC_2693 st077581 4.19 40.7 µM 2.19E-6 27 1.40E-5
10 SGTC_245 methotrexate 3.87 289.6 µM 1.08E-5 46 5.40E-5
11 SGTC_2107 5363541 3.84 170.2 µM 1.26E-5 9 6.13E-5
12 SGTC_1222 0366-0074 3.78 1.2 µM 1.67E-5 TSC3-RPN4 20 7.80E-5
13 SGTC_552 k242-0005 3.58 476.0 µM 4.18E-5 27 1.69E-4
14 SGTC_702 1488-0190 3.56 94.0 µM 4.69E-5 amide catabolism 23 1.87E-4
15 SGTC_561 1550-0330 3.54 72.9 µM 5.02E-5 20 1.98E-4
16 SGTC_2605 digitonin 3.41 300.0 nM 8.85E-5 50 3.20E-4
17 SGTC_2692 st077426 3.34 47.7 µM 1.21E-4 39 4.16E-4
18 SGTC_313 3474-0040 3.27 5.0 µM 1.63E-4 NEO1-PIK1 106 5.36E-4
19 SGTC_2514 salinomycin 3.22 42.7 µM 2.00E-4 92 6.39E-4
20 SGTC_535 2293-4129 3.22 48.2 µM 2.03E-4 NEO1 105 6.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.380 3.71E-115 YGL077C HNM1 hom Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
0.308 1.77E-74 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.288 1.07E-64 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.277 4.40E-60 YPL205C_d YPL205C_d hom Hypothetical protein; deletion of locus affects telomere length
0.267 1.08E-55 YBR245C ISW1 hom ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; ATPase; forms a complex with Ioc3p (Isw1a), and a complex with Ioc2p and Ioc4p (Isw1b); Isw1a and Isw1b have partially overlapping and distinct roles, Isw1a involved in repression of transcription initiation and Isw1b involved in regulation of transcription elongation; Isw1b recruited to open reading frames by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions
0.266 3.43E-55 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.258 1.81E-51 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.256 4.87E-51 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.249 1.82E-48 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.243 2.79E-46 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.234 7.25E-43 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.234 1.64E-42 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.230 3.22E-41 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.228 1.14E-40 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.225 1.06E-39 YER120W SCS2 hom Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; interacts with FFAT motif of Opi1p; involved in telomeric silencing; null shows inositol auxotrophy above 34 deg C; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication