YNL303W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL303W / YNL303W

Click on Significant Values for Screen Details ID:SGTC_151|Compound:3013-0144|FD-Score:3.67|P-value:3.61E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:3.00|P-value:5.94E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:2.91|P-value:8.29E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.95|P-value:6.08E-11 ID:SGTC_433|Compound:pimozide|FD-Score:-3.62|P-value:4.30E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.82|P-value:9.15E-8 ID:SGTC_552|Compound:k242-0005|FD-Score:3.47|P-value:8.73E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:4.46|P-value:7.13E-7 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.17|P-value:2.97E-6 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.79|P-value:1.92E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.00|P-value:5.62E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.60|P-value:4.97E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:3.12|P-value:3.72E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.98|P-value:6.37E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.30|P-value:1.77E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.47|P-value:8.09E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.38|P-value:1.20E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.16|P-value:2.95E-4 ID:SGTC_1689|Compound:st020265|FD-Score:2.90|P-value:8.45E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.57|P-value:5.58E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.72|P-value:2.88E-5 ID:SGTC_1792|Compound:st045773|FD-Score:-3.34|P-value:1.43E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.31|P-value:1.69E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.31|P-value:1.60E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.07|P-value:5.45E-6 ID:SGTC_2320|Compound:7373003|FD-Score:4.47|P-value:6.75E-7 ID:SGTC_2369|Compound:9071472|FD-Score:3.11|P-value:3.94E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-2.96|P-value:6.56E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.16|P-value:2.95E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.26|P-value:2.04E-4 ID:SGTC_2474|Compound:5321570|FD-Score:4.47|P-value:6.51E-7 ID:SGTC_2478|Compound:5763493|FD-Score:-2.96|P-value:6.63E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-2.95|P-value:6.72E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-4.67|P-value:1.97E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.90|P-value:8.03E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.19|P-value:2.94E-6 ID:SGTC_2912|Compound:7964298|FD-Score:-2.96|P-value:6.48E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-4.23|P-value:2.18E-6 ID:SGTC_2946|Compound:9065502|FD-Score:4.85|P-value:7.64E-8 ID:SGTC_2949|Compound:9072542|FD-Score:-7.55|P-value:1.37E-16 ID:SGTC_2955|Compound:9076254|FD-Score:4.09|P-value:4.88E-6 ID:SGTC_2956|Compound:9076196|FD-Score:-5.40|P-value:2.25E-9 ID:SGTC_2957|Compound:9076800|FD-Score:-3.88|P-value:1.29E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-3.12|P-value:3.48E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.12|P-value:3.78E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-2.99|P-value:5.82E-4 ID:SGTC_3017|Compound:9080681|FD-Score:4.17|P-value:3.29E-6 ID:SGTC_3100|Compound:9120536|FD-Score:3.56|P-value:5.99E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-3.44|P-value:9.52E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.05|P-value:4.69E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.03|P-value:5.28E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.67|P-value:3.61E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:3.00|P-value:5.94E-4 ID:SGTC_391|Compound:gliotoxin|FD-Score:2.91|P-value:8.29E-4 ID:SGTC_432|Compound:NS 1619|FD-Score:5.95|P-value:6.08E-11 ID:SGTC_433|Compound:pimozide|FD-Score:-3.62|P-value:4.30E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.82|P-value:9.15E-8 ID:SGTC_552|Compound:k242-0005|FD-Score:3.47|P-value:8.73E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:4.46|P-value:7.13E-7 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.17|P-value:2.97E-6 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.79|P-value:1.92E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.00|P-value:5.62E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.60|P-value:4.97E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:3.12|P-value:3.72E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:2.98|P-value:6.37E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.30|P-value:1.77E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.47|P-value:8.09E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.38|P-value:1.20E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.16|P-value:2.95E-4 ID:SGTC_1689|Compound:st020265|FD-Score:2.90|P-value:8.45E-4 ID:SGTC_1705|Compound:st027868|FD-Score:3.57|P-value:5.58E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.72|P-value:2.88E-5 ID:SGTC_1792|Compound:st045773|FD-Score:-3.34|P-value:1.43E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:3.31|P-value:1.69E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.31|P-value:1.60E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.07|P-value:5.45E-6 ID:SGTC_2320|Compound:7373003|FD-Score:4.47|P-value:6.75E-7 ID:SGTC_2369|Compound:9071472|FD-Score:3.11|P-value:3.94E-4 ID:SGTC_2394|Compound:5221648|FD-Score:-2.96|P-value:6.56E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.16|P-value:2.95E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.26|P-value:2.04E-4 ID:SGTC_2474|Compound:5321570|FD-Score:4.47|P-value:6.51E-7 ID:SGTC_2478|Compound:5763493|FD-Score:-2.96|P-value:6.63E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-2.95|P-value:6.72E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-4.67|P-value:1.97E-7 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.90|P-value:8.03E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:4.19|P-value:2.94E-6 ID:SGTC_2912|Compound:7964298|FD-Score:-2.96|P-value:6.48E-4 ID:SGTC_2945|Compound:9067681|FD-Score:-4.23|P-value:2.18E-6 ID:SGTC_2946|Compound:9065502|FD-Score:4.85|P-value:7.64E-8 ID:SGTC_2949|Compound:9072542|FD-Score:-7.55|P-value:1.37E-16 ID:SGTC_2955|Compound:9076254|FD-Score:4.09|P-value:4.88E-6 ID:SGTC_2956|Compound:9076196|FD-Score:-5.40|P-value:2.25E-9 ID:SGTC_2957|Compound:9076800|FD-Score:-3.88|P-value:1.29E-5 ID:SGTC_2961|Compound:9083290|FD-Score:-3.12|P-value:3.48E-4 ID:SGTC_3000|Compound:9075062|FD-Score:3.12|P-value:3.78E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-2.99|P-value:5.82E-4 ID:SGTC_3017|Compound:9080681|FD-Score:4.17|P-value:3.29E-6 ID:SGTC_3100|Compound:9120536|FD-Score:3.56|P-value:5.99E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-3.44|P-value:9.52E-5 ID:SGTC_3159|Compound:9100096|FD-Score:-3.05|P-value:4.69E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.03|P-value:5.28E-4

Top fitness defect scores for YNL303W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_432 NS 1619 5.95 61.3 µM 6.08E-11 3 1.36E-9
2 SGTC_2946 9065502 4.85 71.4 µM 7.64E-8 3 6.13E-7
3 SGTC_473 2-arachidonoylglycerol 4.82 10.0 µM 9.15E-8 8 7.15E-7
4 SGTC_2474 5321570 4.47 43.3 µM 6.51E-7 5 3.85E-6
5 SGTC_2320 7373003 4.47 200.0 µM 6.75E-7 14 3.97E-6
6 SGTC_654 1124-0271 4.46 80.9 µM 7.13E-7 13 4.16E-6
7 SGTC_2636 apigenin dimethyl ether 4.19 100.0 µM 2.94E-6 36 1.41E-5
8 SGTC_3017 9080681 4.17 49.5 µM 3.29E-6 11 1.55E-5
9 SGTC_2955 9076254 4.09 12.2 µM 4.88E-6 14 2.17E-5
10 SGTC_2289 7946404 4.07 165.1 µM 5.45E-6 88 2.39E-5
11 SGTC_1736 st036774 3.72 51.0 µM 2.88E-5 43 9.98E-5
12 SGTC_151 3013-0144 3.67 2.3 µM 3.61E-5 iron homeostasis 39 1.21E-4
13 SGTC_937 3122-0005 3.60 46.7 µM 4.97E-5 36 1.60E-4
14 SGTC_1705 st027868 3.57 56.3 µM 5.58E-5 18 1.76E-4
15 SGTC_3100 9120536 3.56 49.5 µM 5.99E-5 21 1.87E-4
16 SGTC_552 k242-0005 3.47 476.0 µM 8.73E-5 34 2.59E-4
17 SGTC_2247 cerulenin 3.31 830.0 nM 1.69E-4 40 4.58E-4
18 SGTC_1096 rimcazole 3.30 32.2 µM 1.77E-4 24 4.77E-4
19 SGTC_983 1491-0821 3.12 12.2 µM 3.72E-4 32 9.04E-4
20 SGTC_3000 9075062 3.12 71.4 µM 3.78E-4 52 9.18E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.80E-13 YML058W SML1 hom Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
0.119 5.79E-12 YOR154W_p SLP1_p hom Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p
0.112 8.99E-11 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.108 3.28E-10 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.102 3.22E-9 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.101 5.23E-9 YLR250W SSP120 hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.099 1.03E-8 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.096 2.78E-8 YLR308W CDA2 hom Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
0.095 3.36E-8 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.091 1.56E-7 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.090 1.75E-7 YDL171C GLT1 hom NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
0.090 1.76E-7 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.090 1.87E-7 YDL117W CYK3 hom SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.088 3.21E-7 YHR066W SSF1 hom Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
0.087 4.06E-7 YML011C RAD33 hom Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus