YNL304W / YPT11

Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL304W / YPT11

Click on Significant Values for Screen Details ID:SGTC_357|Compound:1325-0123|FD-Score:3.43|P-value:3.55E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.51|P-value:2.67E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.78|P-value:7.72E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.62|P-value:1.76E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.86|P-value:5.69E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.19|P-value:7.05E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.30|P-value:5.62E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.78|P-value:7.80E-5 ID:SGTC_1609|Compound:st001574|FD-Score:-4.07|P-value:2.39E-5 ID:SGTC_1842|Compound:st055362|FD-Score:3.24|P-value:6.93E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.32|P-value:5.26E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.35|P-value:4.72E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.78|P-value:7.87E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.27|P-value:5.36E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.32|P-value:5.24E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.70|P-value:1.26E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.44|P-value:3.43E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.60|P-value:1.59E-4 ID:SGTC_2815|Compound:7968870|FD-Score:5.10|P-value:2.24E-7 ID:SGTC_2961|Compound:9083290|FD-Score:5.07|P-value:2.55E-7 ID:SGTC_2963|Compound:9082507|FD-Score:-3.68|P-value:1.14E-4 ID:SGTC_3079|Compound:9117512|FD-Score:3.43|P-value:3.47E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.82|P-value:7.97E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.21|P-value:7.67E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.09|P-value:9.87E-4 ID:SGTC_357|Compound:1325-0123|FD-Score:3.43|P-value:3.55E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.51|P-value:2.67E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.78|P-value:7.72E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.62|P-value:1.76E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:-3.86|P-value:5.69E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:-3.19|P-value:7.05E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.30|P-value:5.62E-4 ID:SGTC_1140|Compound:3229-1848|FD-Score:-3.78|P-value:7.80E-5 ID:SGTC_1609|Compound:st001574|FD-Score:-4.07|P-value:2.39E-5 ID:SGTC_1842|Compound:st055362|FD-Score:3.24|P-value:6.93E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.32|P-value:5.26E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.35|P-value:4.72E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.78|P-value:7.87E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.27|P-value:5.36E-4 ID:SGTC_2769|Compound:toremifene|FD-Score:3.32|P-value:5.24E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.70|P-value:1.26E-4 ID:SGTC_2804|Compound:7954240|FD-Score:3.44|P-value:3.43E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-3.60|P-value:1.59E-4 ID:SGTC_2815|Compound:7968870|FD-Score:5.10|P-value:2.24E-7 ID:SGTC_2961|Compound:9083290|FD-Score:5.07|P-value:2.55E-7 ID:SGTC_2963|Compound:9082507|FD-Score:-3.68|P-value:1.14E-4 ID:SGTC_3079|Compound:9117512|FD-Score:3.43|P-value:3.47E-4 ID:SGTC_3212|Compound:9128307|FD-Score:3.82|P-value:7.97E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.21|P-value:7.67E-4 ID:SGTC_3354|Compound:9151612|FD-Score:-3.09|P-value:9.87E-4

Top fitness defect scores for YNL304W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2815 7968870 5.10 71.4 µM 2.24E-7 8 1.71E-7
2 SGTC_2961 9083290 5.07 32.5 µM 2.55E-7 6 1.95E-7
3 SGTC_3212 9128307 3.82 49.5 µM 7.97E-5 49 6.66E-5
4 SGTC_2787 5284540 3.70 71.4 µM 1.26E-4 35 1.06E-4
5 SGTC_506 n9-isopropylolomoucine 3.62 153.0 µM 1.76E-4 14 1.49E-4
6 SGTC_398 bronopol 3.51 33.3 µM 2.67E-4 RNA processing & uracil transport 31 2.27E-4
7 SGTC_2804 7954240 3.44 19.5 µM 3.43E-4 51 2.94E-4
8 SGTC_3079 9117512 3.43 49.5 µM 3.47E-4 5 2.97E-4
9 SGTC_357 1325-0123 3.43 420.0 µM 3.55E-4 15 3.04E-4
10 SGTC_2012 4023501 3.35 200.0 µM 4.72E-4 55 4.06E-4
11 SGTC_2769 toremifene 3.32 3.7 µM 5.24E-4 44 4.52E-4
12 SGTC_1928 4'-methoxychalcone 3.32 40.3 µM 5.26E-4 30 4.53E-4
13 SGTC_795 0685-0265 3.30 78.0 µM 5.62E-4 excess fatty acid 50 4.85E-4
14 SGTC_1842 st055362 3.24 61.2 µM 6.93E-4 35 6.00E-4
15 SGTC_3326 9140064 3.21 16.4 µM 7.67E-4 41 6.65E-4
16 SGTC_3134 9127454 3.11 49.5 µM 0.00106 31 9.26E-4
17 SGTC_394 menadione 3.06 8.3 µM 0.00126 superoxide 68 0.00111
18 SGTC_2762 leflunomide 2.99 42.1 µM 0.00160 76 0.00141
19 SGTC_2051 5263410 2.95 176.0 µM 0.00179 56 0.00158
20 SGTC_6 0844-0013 2.90 19.8 µM 0.00211 229 0.00186

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.34E-12 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.114 3.51E-11 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.108 3.80E-10 YOR095C RKI1 het Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
0.104 1.71E-9 YML042W CAT2 hom Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
0.103 1.84E-9 YDL055C PSA1 het GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
0.097 1.95E-8 YKL214C YRA2 hom Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
0.096 2.80E-8 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.096 2.89E-8 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.092 8.63E-8 YGR100W MDR1 hom Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function
0.092 1.05E-7 YJR107W_p YJR107W_p hom Putative lipase
0.088 3.52E-7 YKL184W SPE1 hom Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
0.086 5.54E-7 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.084 1.15E-6 YOL048C RRT8 hom Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress
0.081 2.94E-6 YEL072W RMD6 hom Protein required for sporulation
0.080 3.14E-6 YHL032C GUT1 hom Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p