YNL305C / BXI1

Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL305C / BXI1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.82|P-value:4.43E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:-3.13|P-value:9.12E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.41|P-value:2.27E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.65|P-value:8.70E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:5.08|P-value:1.01E-7 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.13|P-value:6.38E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.41|P-value:2.24E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.92|P-value:4.47E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-5.72|P-value:4.80E-9 ID:SGTC_526|Compound:4469-0568|FD-Score:-5.56|P-value:1.29E-8 ID:SGTC_527|Compound:4476-4215|FD-Score:-7.03|P-value:7.98E-13 ID:SGTC_529|Compound:4076-0302|FD-Score:-4.21|P-value:1.31E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:4.51|P-value:1.92E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:5.01|P-value:1.44E-7 ID:SGTC_633|Compound:0437-0093|FD-Score:-4.73|P-value:1.12E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:-4.18|P-value:1.48E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:4.01|P-value:1.92E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.56|P-value:1.52E-14 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-10.40|P-value:3.92E-26 ID:SGTC_1109|Compound:tnp00067|FD-Score:-6.01|P-value:8.34E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-9.07|P-value:3.47E-20 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.61|P-value:1.05E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-4.12|P-value:1.91E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.17|P-value:8.00E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.35|P-value:4.29E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.49|P-value:3.58E-6 ID:SGTC_1716|Compound:st033144|FD-Score:3.01|P-value:9.75E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.41|P-value:2.30E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.68|P-value:1.24E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.39|P-value:3.72E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-4.35|P-value:7.02E-6 ID:SGTC_2172|Compound:5754775|FD-Score:-3.92|P-value:4.51E-5 ID:SGTC_2317|Compound:5986382|FD-Score:3.05|P-value:8.36E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.99|P-value:2.12E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.32|P-value:2.71E-8 ID:SGTC_2711|Compound:st079103|FD-Score:-3.19|P-value:7.64E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.86|P-value:3.71E-5 ID:SGTC_2945|Compound:9067681|FD-Score:3.85|P-value:3.89E-5 ID:SGTC_2947|Compound:9072639|FD-Score:4.09|P-value:1.35E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.43|P-value:2.06E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.17|P-value:5.52E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.38|P-value:3.85E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.22|P-value:4.65E-4 ID:SGTC_3349|Compound:9149703|FD-Score:4.96|P-value:1.91E-7 ID:SGTC_3355|Compound:9151058|FD-Score:4.91|P-value:2.55E-7 ID:SGTC_6|Compound:0844-0013|FD-Score:3.82|P-value:4.43E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:-3.13|P-value:9.12E-4 ID:SGTC_338|Compound:4055-0136|FD-Score:3.41|P-value:2.27E-4 ID:SGTC_342|Compound:k048-0088|FD-Score:3.65|P-value:8.70E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:5.08|P-value:1.01E-7 ID:SGTC_403|Compound:arphamenine a|FD-Score:3.13|P-value:6.38E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.41|P-value:2.24E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.92|P-value:4.47E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:-5.72|P-value:4.80E-9 ID:SGTC_526|Compound:4469-0568|FD-Score:-5.56|P-value:1.29E-8 ID:SGTC_527|Compound:4476-4215|FD-Score:-7.03|P-value:7.98E-13 ID:SGTC_529|Compound:4076-0302|FD-Score:-4.21|P-value:1.31E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:4.51|P-value:1.92E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:5.01|P-value:1.44E-7 ID:SGTC_633|Compound:0437-0093|FD-Score:-4.73|P-value:1.12E-6 ID:SGTC_902|Compound:1120-0002|FD-Score:-4.18|P-value:1.48E-5 ID:SGTC_912|Compound:3474-0017|FD-Score:4.01|P-value:1.92E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.56|P-value:1.52E-14 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-10.40|P-value:3.92E-26 ID:SGTC_1109|Compound:tnp00067|FD-Score:-6.01|P-value:8.34E-10 ID:SGTC_1111|Compound:tnp00062|FD-Score:-9.07|P-value:3.47E-20 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.61|P-value:1.05E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:-4.12|P-value:1.91E-5 ID:SGTC_1505|Compound:k297-0037|FD-Score:-3.17|P-value:8.00E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.35|P-value:4.29E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-4.49|P-value:3.58E-6 ID:SGTC_1716|Compound:st033144|FD-Score:3.01|P-value:9.75E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.41|P-value:2.30E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.68|P-value:1.24E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.39|P-value:3.72E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-4.35|P-value:7.02E-6 ID:SGTC_2172|Compound:5754775|FD-Score:-3.92|P-value:4.51E-5 ID:SGTC_2317|Compound:5986382|FD-Score:3.05|P-value:8.36E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.99|P-value:2.12E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.32|P-value:2.71E-8 ID:SGTC_2711|Compound:st079103|FD-Score:-3.19|P-value:7.64E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.86|P-value:3.71E-5 ID:SGTC_2945|Compound:9067681|FD-Score:3.85|P-value:3.89E-5 ID:SGTC_2947|Compound:9072639|FD-Score:4.09|P-value:1.35E-5 ID:SGTC_3046|Compound:9092212|FD-Score:3.43|P-value:2.06E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.17|P-value:5.52E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.38|P-value:3.85E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.22|P-value:4.65E-4 ID:SGTC_3349|Compound:9149703|FD-Score:4.96|P-value:1.91E-7 ID:SGTC_3355|Compound:9151058|FD-Score:4.91|P-value:2.55E-7

Top fitness defect scores for YNL305C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.32 3.7 µM 2.71E-8 23 5.30E-8
2 SGTC_356 1634-0012 5.08 32.5 µM 1.01E-7 9 1.89E-7
3 SGTC_536 3852-0578 5.01 10.6 µM 1.44E-7 9 2.66E-7
4 SGTC_3349 9149703 4.96 23.0 µM 1.91E-7 5 3.51E-7
5 SGTC_3355 9151058 4.91 44.0 µM 2.55E-7 RNA processing & uracil transport 3 4.64E-7
6 SGTC_535 2293-4129 4.51 48.2 µM 1.92E-6 NEO1 49 3.25E-6
7 SGTC_2947 9072639 4.09 7.7 µM 1.35E-5 tubulin folding & SWR complex 38 2.14E-5
8 SGTC_912 3474-0017 4.01 2.2 µM 1.92E-5 21 3.01E-5
9 SGTC_2319 6033012 3.99 152.6 µM 2.12E-5 tubulin folding & SWR complex 31 3.32E-5
10 SGTC_2713 st079149 3.86 53.4 µM 3.71E-5 21 5.69E-5
11 SGTC_2945 9067681 3.85 61.8 µM 3.89E-5 16 5.96E-5
12 SGTC_6 0844-0013 3.82 19.8 µM 4.43E-5 99 6.75E-5
13 SGTC_342 k048-0088 3.65 23.3 µM 8.70E-5 RSC & ERG11 27 1.29E-4
14 SGTC_1203 3992-3522 3.61 103.0 µM 1.05E-4 50 1.55E-4
15 SGTC_3046 9092212 3.43 49.5 µM 2.06E-4 17 2.97E-4
16 SGTC_408 cantharidin 3.41 100.0 µM 2.24E-4 cell wall signaling 37 3.23E-4
17 SGTC_338 4055-0136 3.41 114.0 µM 2.27E-4 21 3.25E-4
18 SGTC_1913 st060213 3.41 96.1 µM 2.30E-4 56 3.30E-4
19 SGTC_3203 9113543 3.22 49.5 µM 4.65E-4 67 6.51E-4
20 SGTC_3120 9124077 3.17 49.5 µM 5.52E-4 39 7.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 6.88E-43 YLL051C FRE6 hom Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
0.181 3.18E-26 YGL086W MAD1 hom Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
0.173 6.59E-24 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.172 1.44E-23 YLR407W_p YLR407W_p hom Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
0.170 4.76E-23 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.165 5.78E-22 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.158 4.29E-20 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.158 4.25E-20 YER030W CHZ1 hom Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.155 1.70E-19 YJL130C URA2 hom Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
0.154 2.69E-19 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.152 8.94E-19 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.151 1.34E-18 YIR038C GTT1 hom ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
0.149 4.48E-18 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.148 5.91E-18 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.148 6.98E-18 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery