HIPHOP chemogenomics database

YNL305C / BXI1

Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p

Zygosity: Homozygous strain

fixedexpanded
Profile for YNL305C / BXI1

Click on Significant Values for Screen Details

Top fitness defect scores for YNL305C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2494	18-aminoabieta-8,11,13-triene sulfate	5.32	3.7 µM	2.71E-8		23	5.30E-8
2	SGTC_356	1634-0012	5.08	32.5 µM	1.01E-7		9	1.89E-7
3	SGTC_536	3852-0578	5.01	10.6 µM	1.44E-7		9	2.66E-7
4	SGTC_3349	9149703	4.96	23.0 µM	1.91E-7		5	3.51E-7
5	SGTC_3355	9151058	4.91	44.0 µM	2.55E-7	RNA processing & uracil transport	3	4.64E-7
6	SGTC_535	2293-4129	4.51	48.2 µM	1.92E-6	NEO1	49	3.25E-6
7	SGTC_2947	9072639	4.09	7.7 µM	1.35E-5	tubulin folding & SWR complex	38	2.14E-5
8	SGTC_912	3474-0017	4.01	2.2 µM	1.92E-5		21	3.01E-5
9	SGTC_2319	6033012	3.99	152.6 µM	2.12E-5	tubulin folding & SWR complex	31	3.32E-5
10	SGTC_2713	st079149	3.86	53.4 µM	3.71E-5		21	5.69E-5
11	SGTC_2945	9067681	3.85	61.8 µM	3.89E-5		16	5.96E-5
12	SGTC_6	0844-0013	3.82	19.8 µM	4.43E-5		99	6.75E-5
13	SGTC_342	k048-0088	3.65	23.3 µM	8.70E-5	RSC & ERG11	27	1.29E-4
14	SGTC_1203	3992-3522	3.61	103.0 µM	1.05E-4		50	1.55E-4
15	SGTC_3046	9092212	3.43	49.5 µM	2.06E-4		17	2.97E-4
16	SGTC_408	cantharidin	3.41	100.0 µM	2.24E-4	cell wall signaling	37	3.23E-4
17	SGTC_338	4055-0136	3.41	114.0 µM	2.27E-4		21	3.25E-4
18	SGTC_1913	st060213	3.41	96.1 µM	2.30E-4		56	3.30E-4
19	SGTC_3203	9113543	3.22	49.5 µM	4.65E-4		67	6.51E-4
20	SGTC_3120	9124077	3.17	49.5 µM	5.52E-4		39	7.67E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.234	6.88E-43	YLL051C	FRE6	hom	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels
0.181	3.18E-26	YGL086W	MAD1	hom	Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
0.173	6.59E-24	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.172	1.44E-23	YLR407W_p	YLR407W_p	hom	Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
0.170	4.76E-23	YLR288C	MEC3	hom	DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.165	5.78E-22	YGL017W	ATE1	hom	Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.158	4.29E-20	YDL110C	TMA17	hom	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.158	4.25E-20	YER030W	CHZ1	hom	Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress
0.155	1.70E-19	YJL130C	URA2	hom	Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
0.154	2.69E-19	YOR298C-A	MBF1	hom	Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.152	8.94E-19	YER067C-A_d	YER067C-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.151	1.34E-18	YIR038C	GTT1	hom	ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
0.149	4.48E-18	YMR173W	DDR48	hom	DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.148	5.91E-18	YDL049C	KNH1	hom	Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.148	6.98E-18	YBL086C_p	YBL086C_p	hom	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery