HIPHOP chemogenomics database

YNL306W / MRPS18

Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins

Zygosity: Heterozygous strain

fixedexpanded
Profile for YNL306W / MRPS18

Click on Significant Values for Screen Details

Top fitness defect scores for YNL306W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_1013	4112-3890	5.11	241.0 µM	1.51E-9	TSC3-RPN4	3	1.65E-7	0.54
2	SGTC_2505	galangin	3.95	7.9 µM	2.26E-6	RPP1 & pyrimidine depletion	7	3.84E-5	0.31
3	SGTC_1017	4239-0030	3.81	168.0 µM	5.01E-6		3	6.96E-5	0.30
4	SGTC_1570	verbenone	3.77	133.0 µM	6.07E-6		5	8.04E-5	0.14
5	SGTC_2504	purpurogallin	3.65	52.3 µM	1.19E-5	RPP1 & pyrimidine depletion	5	1.33E-4	0.10
6	SGTC_795	0685-0265	3.65	78.0 µM	1.19E-5	excess fatty acid	25	1.33E-4	0.03
7	SGTC_2793	7325131	3.61	81.8 µM	1.41E-5		11	1.51E-4	0.25
8	SGTC_152	4469-0003	3.61	551.2 µM	1.41E-5		18	1.51E-4	0.12
9	SGTC_522	1273-0010	3.57	11.6 µM	1.73E-5	60S ribosome export	9	1.76E-4	0.16
10	SGTC_2107	5363541	3.52	170.2 µM	2.28E-5		11	2.17E-4	0.00
11	SGTC_67	0335-0847	3.47	266.0 µM	2.96E-5	ubiquinone biosynthesis & proteasome	30	2.64E-4	0.00
12	SGTC_1010	4112-3296	3.35	15.2 µM	5.15E-5		10	3.99E-4	0.02
13	SGTC_3328	9140624	3.10	29.0 µM	1.66E-4		11	9.66E-4	0.01
14	SGTC_1169	aniline yellow	3.05	25.8 µM	2.06E-4		7	0.00113	0.05
15	SGTC_2550	chrysin dimethyl ether	3.03	71.9 µM	2.24E-4		4	0.00121	0.22
16	SGTC_136	0097-0015	3.02	404.5 µM	2.34E-4	60S ribosome export	15	0.00125	0.11
17	SGTC_1930	st074634	3.01	34.3 µM	2.45E-4	RNA pol III & RNase P/MRP	27	0.00129	0.00
18	SGTC_2491	paeonol	2.87	100.0 µM	4.44E-4		5	0.00203	0.06
19	SGTC_2574	2',4'-dihydroxychalcone	2.87	14.6 µM	4.53E-4		27	0.00206	0.02
20	SGTC_2557	derrustone	2.86	83.8 µM	4.70E-4		12	0.00212	0.06

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.156	1.17E-19	YJL028W	YJL028W	hom	Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.147	1.04E-17	YNL203C_d	YNL203C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.136	2.24E-15	YLR414C	PUN1	hom	Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.136	3.34E-15	YPR024W	YME1	hom	Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.132	1.37E-14	YJL058C	BIT61	hom	Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.127	1.31E-13	YKL024C	URA6	het	Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.119	4.22E-12	YMR110C	HFD1	hom	Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.112	9.25E-11	YGL004C	RPN14	hom	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.104	1.69E-9	YBR205W	KTR3	hom	Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress
0.102	2.73E-9	YDR344C_d	YDR344C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.102	2.81E-9	YCL049C_p	YCL049C_p	hom	Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene
0.095	3.08E-8	YCR083W	TRX3	hom	Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p
0.095	3.60E-8	YGR048W	UFD1	het	Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
0.095	3.74E-8	YKL111C_d	YKL111C_d	het	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1
0.094	5.11E-8	YOR248W_d	YOR248W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data