HIPHOP chemogenomics database
YNL313C / EMW1 
Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YNL313C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.141 | 2.49E-16 | YJR117W | STE24 | hom | Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans |
| 0.137 | 1.99E-15 | YPL010W | RET3 | het | Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER |
| 0.116 | 1.39E-11 | YNL232W | CSL4 | het | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) |
| 0.114 | 3.98E-11 | YCR095W-A_p | YCR095W-A_p | hom | Putative protein of unknown function |
| 0.113 | 5.58E-11 | YLL001W | DNM1 | hom | Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance |
| 0.106 | 6.98E-10 | YMR185W | RTP1 | het | Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene |
| 0.106 | 8.20E-10 | YDR249C_p | YDR249C_p | hom | Putative protein of unknown function |
| 0.102 | 2.84E-9 | YKR045C_p | YKR045C_p | hom | Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm |
| 0.100 | 6.95E-9 | YMR155W_p | YMR155W_p | hom | Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen |
| 0.098 | 1.48E-8 | YDL208W | NHP2 | het | Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing |
| 0.096 | 2.85E-8 | YAL024C | LTE1 | hom | Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures |
| 0.096 | 2.96E-8 | YDR530C | APA2 | hom | Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication |
| 0.094 | 5.50E-8 | YOR262W | GPN2 | het | Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion |
| 0.091 | 1.41E-7 | YOR116C | RPO31 | het | RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 |
| 0.090 | 1.78E-7 | YDR219C | MFB1 | hom | Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding |