YNL314W / DAL82

Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL314W / DAL82

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:19.30|P-value:2.63E-91 ID:SGTC_66|Compound:0109-0187|FD-Score:-6.48|P-value:4.26E-12 ID:SGTC_138|Compound:0850-0259|FD-Score:5.20|P-value:2.94E-8 ID:SGTC_146|Compound:3448-8650|FD-Score:3.47|P-value:1.53E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.98|P-value:1.28E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:2.98|P-value:9.75E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.87|P-value:2.82E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.31|P-value:3.58E-6 ID:SGTC_606|Compound:k015-0008|FD-Score:3.96|P-value:1.87E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.52|P-value:1.24E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-3.19|P-value:3.71E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.31|P-value:2.36E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.14|P-value:5.38E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.71|P-value:5.70E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:3.76|P-value:4.55E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.25|P-value:3.67E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.35|P-value:2.47E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.67|P-value:6.53E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:3.53|P-value:1.19E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.30|P-value:2.97E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.46|P-value:1.56E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.10|P-value:9.73E-6 ID:SGTC_937|Compound:3122-0005|FD-Score:3.93|P-value:2.11E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.38|P-value:2.23E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.12|P-value:5.91E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.24|P-value:3.71E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.34|P-value:2.54E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.23|P-value:3.96E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.04|P-value:7.79E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:5.55|P-value:3.51E-9 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.63|P-value:7.06E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.29|P-value:2.55E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.11|P-value:5.01E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.80|P-value:3.73E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.00|P-value:9.12E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:2.99|P-value:9.43E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.64|P-value:5.91E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.23|P-value:3.86E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.98|P-value:1.70E-5 ID:SGTC_1772|Compound:st048439|FD-Score:2.99|P-value:9.33E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.24|P-value:3.81E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.03|P-value:8.19E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.09|P-value:6.58E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.10|P-value:6.33E-4 ID:SGTC_1916|Compound:st067606|FD-Score:6.56|P-value:3.75E-12 ID:SGTC_2064|Compound:5220758|FD-Score:3.16|P-value:5.15E-4 ID:SGTC_2162|Compound:5663267|FD-Score:4.75|P-value:3.59E-7 ID:SGTC_2178|Compound:5812956|FD-Score:4.87|P-value:1.92E-7 ID:SGTC_2268|Compound:7933382|FD-Score:3.64|P-value:7.47E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-3.76|P-value:3.54E-5 ID:SGTC_2330|Compound:7979373|FD-Score:4.29|P-value:3.82E-6 ID:SGTC_2427|Compound:5545055|FD-Score:-3.38|P-value:1.74E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.00|P-value:1.58E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.19|P-value:4.62E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.14|P-value:5.42E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.08|P-value:5.57E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:3.43|P-value:1.81E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.95|P-value:1.92E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.13|P-value:5.59E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.27|P-value:1.96E-8 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.19|P-value:4.49E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.78|P-value:4.14E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.78|P-value:4.21E-5 ID:SGTC_2874|Compound:9043904|FD-Score:4.30|P-value:3.72E-6 ID:SGTC_2909|Compound:7941780|FD-Score:4.49|P-value:1.43E-6 ID:SGTC_2912|Compound:7964298|FD-Score:3.31|P-value:2.90E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.00|P-value:7.38E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.46|P-value:1.62E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.12|P-value:8.70E-6 ID:SGTC_3146|Compound:9095609|FD-Score:3.44|P-value:1.75E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.09|P-value:6.69E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.92|P-value:2.18E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.44|P-value:1.73E-4 ID:SGTC_3311|Compound:9131146|FD-Score:8.58|P-value:1.53E-19 ID:SGTC_3321|Compound:9137793|FD-Score:5.29|P-value:1.69E-8 ID:SGTC_3351|Compound:9150312|FD-Score:4.54|P-value:1.10E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:19.30|P-value:2.63E-91 ID:SGTC_66|Compound:0109-0187|FD-Score:-6.48|P-value:4.26E-12 ID:SGTC_138|Compound:0850-0259|FD-Score:5.20|P-value:2.94E-8 ID:SGTC_146|Compound:3448-8650|FD-Score:3.47|P-value:1.53E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-3.98|P-value:1.28E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:2.98|P-value:9.75E-4 ID:SGTC_399|Compound:oxolinic acid|FD-Score:3.87|P-value:2.82E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:4.31|P-value:3.58E-6 ID:SGTC_606|Compound:k015-0008|FD-Score:3.96|P-value:1.87E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.52|P-value:1.24E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-3.19|P-value:3.71E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:-3.31|P-value:2.36E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.14|P-value:5.38E-4 ID:SGTC_782|Compound:0083-0095|FD-Score:3.71|P-value:5.70E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:3.76|P-value:4.55E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.25|P-value:3.67E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:3.35|P-value:2.47E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:3.67|P-value:6.53E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:3.53|P-value:1.19E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.30|P-value:2.97E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.46|P-value:1.56E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.10|P-value:9.73E-6 ID:SGTC_937|Compound:3122-0005|FD-Score:3.93|P-value:2.11E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:3.38|P-value:2.23E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:3.12|P-value:5.91E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:3.24|P-value:3.71E-4 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.34|P-value:2.54E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.23|P-value:3.96E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.04|P-value:7.79E-4 ID:SGTC_1164|Compound:k060-0068|FD-Score:5.55|P-value:3.51E-9 ID:SGTC_1213|Compound:1315-0166|FD-Score:4.63|P-value:7.06E-7 ID:SGTC_1245|Compound:0418-0076|FD-Score:-3.29|P-value:2.55E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:-3.11|P-value:5.01E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:3.80|P-value:3.73E-5 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.00|P-value:9.12E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:2.99|P-value:9.43E-4 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.64|P-value:5.91E-5 ID:SGTC_1712|Compound:st032288|FD-Score:3.23|P-value:3.86E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.98|P-value:1.70E-5 ID:SGTC_1772|Compound:st048439|FD-Score:2.99|P-value:9.33E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.24|P-value:3.81E-4 ID:SGTC_1833|Compound:st055984|FD-Score:3.03|P-value:8.19E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.09|P-value:6.58E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.10|P-value:6.33E-4 ID:SGTC_1916|Compound:st067606|FD-Score:6.56|P-value:3.75E-12 ID:SGTC_2064|Compound:5220758|FD-Score:3.16|P-value:5.15E-4 ID:SGTC_2162|Compound:5663267|FD-Score:4.75|P-value:3.59E-7 ID:SGTC_2178|Compound:5812956|FD-Score:4.87|P-value:1.92E-7 ID:SGTC_2268|Compound:7933382|FD-Score:3.64|P-value:7.47E-5 ID:SGTC_2273|Compound:7815444|FD-Score:-3.76|P-value:3.54E-5 ID:SGTC_2330|Compound:7979373|FD-Score:4.29|P-value:3.82E-6 ID:SGTC_2427|Compound:5545055|FD-Score:-3.38|P-value:1.74E-4 ID:SGTC_2435|Compound:5706476|FD-Score:4.00|P-value:1.58E-5 ID:SGTC_2486|Compound:5283202|FD-Score:3.19|P-value:4.62E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.14|P-value:5.42E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.08|P-value:5.57E-4 ID:SGTC_2545|Compound:solidagenone|FD-Score:3.43|P-value:1.81E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.95|P-value:1.92E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.13|P-value:5.59E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.27|P-value:1.96E-8 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:3.19|P-value:4.49E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:3.78|P-value:4.14E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:3.78|P-value:4.21E-5 ID:SGTC_2874|Compound:9043904|FD-Score:4.30|P-value:3.72E-6 ID:SGTC_2909|Compound:7941780|FD-Score:4.49|P-value:1.43E-6 ID:SGTC_2912|Compound:7964298|FD-Score:3.31|P-value:2.90E-4 ID:SGTC_2920|Compound:7982904|FD-Score:-3.00|P-value:7.38E-4 ID:SGTC_3025|Compound:9087895|FD-Score:3.46|P-value:1.62E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.12|P-value:8.70E-6 ID:SGTC_3146|Compound:9095609|FD-Score:3.44|P-value:1.75E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.09|P-value:6.69E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.92|P-value:2.18E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.44|P-value:1.73E-4 ID:SGTC_3311|Compound:9131146|FD-Score:8.58|P-value:1.53E-19 ID:SGTC_3321|Compound:9137793|FD-Score:5.29|P-value:1.69E-8 ID:SGTC_3351|Compound:9150312|FD-Score:4.54|P-value:1.10E-6

Top fitness defect scores for YNL314W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 19.30 9.0 µM 2.63E-91 cell wall 13 2.07E-83
2 SGTC_3311 9131146 8.58 2.9 µM 1.53E-19 cell wall 25 4.94E-18
3 SGTC_1916 st067606 6.56 49.2 µM 3.75E-12 6 2.77E-11
4 SGTC_1164 k060-0068 5.55 93.7 µM 3.51E-9 7 1.45E-8
5 SGTC_3321 9137793 5.29 26.8 µM 1.69E-8 cell wall 38 6.08E-8
6 SGTC_2584 androsterone 5.27 48.7 µM 1.96E-8 cell wall 73 6.98E-8
7 SGTC_138 0850-0259 5.20 40.9 µM 2.94E-8 cell wall 137 1.01E-7
8 SGTC_2178 5812956 4.87 200.0 µM 1.92E-7 4 5.66E-7
9 SGTC_2162 5663267 4.75 200.0 µM 3.59E-7 6 1.00E-6
10 SGTC_1213 1315-0166 4.63 115.0 µM 7.06E-7 15 1.87E-6
11 SGTC_3351 9150312 4.54 21.6 µM 1.10E-6 cell wall 26 2.81E-6
12 SGTC_2909 7941780 4.49 10.5 µM 1.43E-6 9 3.57E-6
13 SGTC_514 4466-0038 4.31 2.6 nM 3.58E-6 cell wall 133 8.27E-6
14 SGTC_2874 9043904 4.30 71.4 µM 3.72E-6 6 8.56E-6
15 SGTC_2330 7979373 4.29 200.0 µM 3.82E-6 60S ribosome export 25 8.77E-6
16 SGTC_3143 9086658 4.12 49.5 µM 8.70E-6 37 1.87E-5
17 SGTC_928 2764-0428 4.10 58.7 µM 9.73E-6 cell wall 54 2.07E-5
18 SGTC_2435 5706476 4.00 10.6 µM 1.58E-5 24 3.23E-5
19 SGTC_1719 st032227 3.98 49.2 µM 1.70E-5 21 3.45E-5
20 SGTC_606 k015-0008 3.96 38.6 µM 1.87E-5 13 3.78E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.467 1.66E-181 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.428 1.93E-149 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.403 5.81E-131 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.395 5.55E-126 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.391 3.09E-123 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.384 2.62E-118 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.384 3.72E-118 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.369 1.41E-108 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.365 1.91E-106 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.362 3.29E-104 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.359 2.03E-102 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.354 8.50E-100 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.348 2.47E-96 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.347 2.77E-95 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.346 7.41E-95 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene