YNL329C / PEX6

AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol

Zygosity: Homozygous strain
fixedexpanded
Profile for YNL329C / PEX6

Click on Significant Values for Screen Details ID:SGTC_88|Compound:0180-0332|FD-Score:3.23|P-value:9.58E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.29|P-value:8.15E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.42|P-value:5.29E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.70|P-value:1.93E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:4.84|P-value:1.71E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:3.22|P-value:9.80E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:5.40|P-value:1.09E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:4.45|P-value:9.71E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:5.20|P-value:3.02E-7 ID:SGTC_834|Compound:0312-0008|FD-Score:3.27|P-value:8.53E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.79|P-value:1.38E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.62|P-value:2.57E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.92|P-value:8.44E-5 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.69|P-value:2.38E-8 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.27|P-value:8.32E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.91|P-value:8.58E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.72|P-value:1.79E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.07|P-value:4.73E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.28|P-value:8.21E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.50|P-value:3.89E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.28|P-value:8.11E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.61|P-value:2.78E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.97|P-value:6.79E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.51|P-value:3.77E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.57|P-value:3.00E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.49|P-value:4.11E-4 ID:SGTC_1724|Compound:st037281|FD-Score:6.45|P-value:3.06E-10 ID:SGTC_1780|Compound:st038448|FD-Score:4.45|P-value:9.68E-6 ID:SGTC_1832|Compound:st054113|FD-Score:3.60|P-value:2.76E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-3.48|P-value:4.30E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.87|P-value:1.03E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.39|P-value:5.61E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.40|P-value:5.69E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.43|P-value:4.96E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.00|P-value:8.13E-7 ID:SGTC_2184|Compound:6075246|FD-Score:5.40|P-value:1.11E-7 ID:SGTC_2478|Compound:5763493|FD-Score:-4.01|P-value:6.18E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-4.21|P-value:2.72E-5 ID:SGTC_2487|Compound:5918373|FD-Score:-4.44|P-value:1.05E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.12|P-value:3.75E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:5.15|P-value:3.79E-7 ID:SGTC_2760|Compound:etidronate|FD-Score:3.63|P-value:2.42E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.14|P-value:3.47E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.77|P-value:1.49E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-3.82|P-value:1.26E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.57|P-value:3.02E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.80|P-value:1.32E-4 ID:SGTC_88|Compound:0180-0332|FD-Score:3.23|P-value:9.58E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.29|P-value:8.15E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:-3.42|P-value:5.29E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.70|P-value:1.93E-4 ID:SGTC_356|Compound:1634-0012|FD-Score:4.84|P-value:1.71E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:3.22|P-value:9.80E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:5.40|P-value:1.09E-7 ID:SGTC_674|Compound:0498-0004|FD-Score:4.45|P-value:9.71E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:5.20|P-value:3.02E-7 ID:SGTC_834|Compound:0312-0008|FD-Score:3.27|P-value:8.53E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.79|P-value:1.38E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.62|P-value:2.57E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.92|P-value:8.44E-5 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.69|P-value:2.38E-8 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.27|P-value:8.32E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.91|P-value:8.58E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.72|P-value:1.79E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:4.07|P-value:4.73E-5 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.28|P-value:8.21E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.50|P-value:3.89E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.28|P-value:8.11E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:-3.61|P-value:2.78E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.97|P-value:6.79E-5 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.51|P-value:3.77E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:3.57|P-value:3.00E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.49|P-value:4.11E-4 ID:SGTC_1724|Compound:st037281|FD-Score:6.45|P-value:3.06E-10 ID:SGTC_1780|Compound:st038448|FD-Score:4.45|P-value:9.68E-6 ID:SGTC_1832|Compound:st054113|FD-Score:3.60|P-value:2.76E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-3.48|P-value:4.30E-4 ID:SGTC_1923|Compound:st058458|FD-Score:3.87|P-value:1.03E-4 ID:SGTC_1927|Compound:st060202|FD-Score:3.39|P-value:5.61E-4 ID:SGTC_2064|Compound:5220758|FD-Score:-3.40|P-value:5.69E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.43|P-value:4.96E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:5.00|P-value:8.13E-7 ID:SGTC_2184|Compound:6075246|FD-Score:5.40|P-value:1.11E-7 ID:SGTC_2478|Compound:5763493|FD-Score:-4.01|P-value:6.18E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-4.21|P-value:2.72E-5 ID:SGTC_2487|Compound:5918373|FD-Score:-4.44|P-value:1.05E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:4.12|P-value:3.75E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:5.15|P-value:3.79E-7 ID:SGTC_2760|Compound:etidronate|FD-Score:3.63|P-value:2.42E-4 ID:SGTC_2932|Compound:9016711|FD-Score:4.14|P-value:3.47E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.77|P-value:1.49E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-3.82|P-value:1.26E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.57|P-value:3.02E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.80|P-value:1.32E-4

Top fitness defect scores for YNL329C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1724 st037281 6.45 8.3 µM 3.06E-10 8 5.70E-11
2 SGTC_1001 4048-4355 5.69 44.4 µM 2.38E-8 copper-dependent oxidative stress 14 6.39E-9
3 SGTC_547 1120-0019 5.40 610.0 nM 1.09E-7 azole & statin 11 3.31E-8
4 SGTC_2184 6075246 5.40 200.0 µM 1.11E-7 7 3.39E-8
5 SGTC_690 glyoxal 5.20 20.3 µM 3.02E-7 58 1.01E-7
6 SGTC_2756 carbadox 5.15 75.1 µM 3.79E-7 30 1.28E-7
7 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 5.00 49.5 µM 8.13E-7 7 2.94E-7
8 SGTC_356 1634-0012 4.84 32.5 µM 1.71E-6 11 6.57E-7
9 SGTC_1780 st038448 4.45 24.5 µM 9.68E-6 iron homeostasis 7 4.29E-6
10 SGTC_674 0498-0004 4.45 451.0 µM 9.71E-6 heme requiring 13 4.31E-6
11 SGTC_2932 9016711 4.14 44.5 µM 3.47E-5 43 1.71E-5
12 SGTC_2753 fluvastatin 4.12 17.1 µM 3.75E-5 azole & statin 32 1.86E-5
13 SGTC_1166 k206-0078 4.07 225.0 µM 4.73E-5 17 2.39E-5
14 SGTC_1451 4152-0210 3.97 104.0 µM 6.79E-5 26 3.53E-5
15 SGTC_990 3985-0011 3.92 41.3 µM 8.44E-5 amide catabolism 21 4.47E-5
16 SGTC_1099 5-nonyloxytryptamine 3.91 2.9 µM 8.58E-5 21 4.55E-5
17 SGTC_1923 st058458 3.87 19.1 µM 1.03E-4 35 5.55E-5
18 SGTC_3306 9127676 3.80 59.8 µM 1.32E-4 26 7.23E-5
19 SGTC_881 0833-0569 3.79 170.0 µM 1.38E-4 36 7.61E-5
20 SGTC_3044 9093193 3.77 49.5 µM 1.49E-4 29 8.28E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 8.29E-15 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.116 1.73E-11 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.102 2.62E-9 YDL195W SEC31 het Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
0.097 2.01E-8 YIL098C FMC1 hom Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
0.089 2.61E-7 YPL245W_p YPL245W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.086 5.93E-7 YOR339C UBC11 hom Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2
0.085 7.28E-7 YJL128C PBS2 hom MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition
0.083 1.44E-6 YDR513W GRX2 hom Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has a paralog, GRX1, that arose from the whole genome duplication
0.083 1.68E-6 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.081 2.61E-6 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.081 2.64E-6 YMR068W AVO2 hom Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
0.080 3.45E-6 YHR083W SAM35 het Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
0.080 3.95E-6 YJL110C GZF3 hom GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication
0.079 4.37E-6 YFR043C IRC6 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
0.077 8.06E-6 YBR236C ABD1 het Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA