HIPHOP chemogenomics database

YNR005C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YNR005C / YNR005C

Click on Significant Values for Screen Details

Top fitness defect scores for YNR005C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2582	agaric acid	10.70	100.0 µM	8.25E-22	redox potentiating	52	3.27E-27
2	SGTC_1844	rapamycin	8.90	4.0 nM	1.45E-15		46	2.86E-19
3	SGTC_2679	rapamycin	5.97	1.0 nM	5.58E-8		77	1.19E-9
4	SGTC_227	fluconazole	5.51	33.5 µM	4.74E-7	azole & statin	47	1.78E-8
5	SGTC_1680	diphenhydramine	5.51	100.0 µM	4.83E-7	NEO1	8	1.83E-8
6	SGTC_1071	trifluoperazine	5.30	6.3 µM	1.19E-6		12	5.68E-8
7	SGTC_1658	st012944	5.28	20.0 µM	1.31E-6	iron homeostasis	41	6.41E-8
8	SGTC_2005	4024620	5.21	188.0 µM	1.79E-6		5	9.55E-8
9	SGTC_525	k781-2675	5.02	26.7 µM	3.95E-6	redox potentiating	32	2.59E-7
10	SGTC_1873	rapamycin	4.76	2.0 nM	1.13E-5		53	9.72E-7
11	SGTC_50	0929-0078	4.70	56.4 µM	1.41E-5		34	1.29E-6
12	SGTC_2584	androsterone	4.44	48.7 µM	3.85E-5	cell wall	96	4.54E-6
13	SGTC_3175	9106517	4.37	49.5 µM	4.87E-5	iron homeostasis	13	6.10E-6
14	SGTC_73	0327-0325	4.33	16.2 µM	5.74E-5	DNA damage response	37	7.50E-6
15	SGTC_358	0075-0058	4.33	9.4 µM	5.82E-5		49	7.62E-6
16	SGTC_1605	st000082	4.28	49.1 µM	6.77E-5	60S ribosome export	9	9.22E-6
17	SGTC_754	3474-0146	4.27	171.0 µM	7.20E-5	copper-dependent oxidative stress	19	9.97E-6
18	SGTC_919	tnp00227	4.22	403.6 nM	8.43E-5	RNA pol III & RNase P/MRP	26	1.21E-5
19	SGTC_817	1391-0715	4.16	46.0 µM	1.04E-4		14	1.57E-5
20	SGTC_1495	4469-0029	4.12	237.0 µM	1.22E-4		102	1.94E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.277	3.24E-60	YKR035W-A	DID2	hom	Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors
0.244	1.16E-46	YKL203C	TOR2	het	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.235	2.05E-43	YJR066W	TOR1	hom	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.232	2.63E-42	YNL106C	INP52	hom	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.231	6.40E-42	YLR119W	SRN2	hom	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.226	3.83E-40	YLR384C	IKI3	hom	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.223	8.18E-39	YNR006W	VPS27	hom	Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.221	2.02E-38	YPR173C	VPS4	hom	AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
0.215	2.34E-36	YHR186C	KOG1	het	Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.211	5.30E-35	YGR200C	ELP2	hom	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
0.208	3.21E-34	YAL002W	VPS8	hom	Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.207	9.26E-34	YGR206W	MVB12	hom	ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.206	2.41E-33	YKR035C_d	OPI8_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A
0.200	1.01E-31	YDL172C_d	YDL172C_d	hom	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.197	9.31E-31	YCL008C	STP22	hom	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype