HIPHOP chemogenomics database

YNR014W_p

Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YNR014W / YNR014W

Click on Significant Values for Screen Details

Top fitness defect scores for YNR014W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2975	9084847	5.21	53.7 µM	5.66E-7		4	9.42E-8
2	SGTC_807	1315-0151	5.03	48.0 µM	1.29E-6		12	2.42E-7
3	SGTC_835	0312-0010	5.02	67.2 µM	1.38E-6		3	2.61E-7
4	SGTC_43	0570-0105	4.65	72.5 µM	6.90E-6	ERG2	62	1.63E-6
5	SGTC_3207	9114163	4.59	49.5 µM	8.92E-6		16	2.19E-6
6	SGTC_2957	9076800	4.50	11.5 µM	1.31E-5		16	3.39E-6
7	SGTC_1060	3448-7350	4.24	82.0 µM	3.74E-5	Golgi	27	1.12E-5
8	SGTC_1723	st034307	4.00	2.5 µM	9.34E-5	mitochondrial processes	29	3.17E-5
9	SGTC_2795	7780010	3.94	54.5 µM	1.15E-4		29	4.01E-5
10	SGTC_624	k048-0052	3.94	28.0 µM	1.17E-4	Golgi	15	4.10E-5
11	SGTC_451	chloral hydrate	3.93	100.0 µM	1.19E-4		51	4.18E-5
12	SGTC_2334	9017922	3.92	200.0 µM	1.24E-4		25	4.38E-5
13	SGTC_1182	1222-0449	3.86	220.0 µM	1.54E-4		21	5.58E-5
14	SGTC_2592	piperlongumine	3.85	83.3 µM	1.60E-4	TSC3-RPN4	42	5.84E-5
15	SGTC_1150	3909-7983	3.81	10.9 µM	1.87E-4		29	6.99E-5
16	SGTC_2349	9023730	3.74	187.1 µM	2.40E-4		29	9.26E-5
17	SGTC_2963	9082507	3.73	9.0 µM	2.45E-4		31	9.47E-5
18	SGTC_280	3448-3607	3.70	3.0 µM	2.73E-4	60S ribosome export	13	1.07E-4
19	SGTC_1029	k015-0030	3.69	64.7 µM	2.79E-4		36	1.10E-4
20	SGTC_382	3229-0966	3.68	23.2 µM	2.89E-4		30	1.14E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.111	1.37E-10	YKL202W_d	YKL202W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108	3.36E-10	YML087C	AIM33	hom	Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.095	3.95E-8	YNL001W	DOM34	hom	Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.093	6.00E-8	YGR205W	TDA10	hom	ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
0.090	1.74E-7	YPR176C	BET2	het	Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.089	2.76E-7	YER163C	GCG1	hom	Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle
0.088	2.89E-7	YBL070C_d	YBL070C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.082	1.73E-6	YOL013W-B_d	YOL013W-B_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element
0.081	2.93E-6	YNL268W	LYP1	hom	Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.080	3.83E-6	YER001W	MNN1	hom	Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.079	5.18E-6	YPL270W	MDL2	hom	Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
0.078	5.53E-6	YMR117C	SPC24	het	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.076	9.72E-6	YDR416W	SYF1	het	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.075	1.40E-5	YKL137W	CMC1	hom	Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
0.074	1.63E-5	YCL028W	RNQ1	hom	[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate