YNR014W_p

Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR014W / YNR014W

Click on Significant Values for Screen Details ID:SGTC_43|Compound:0570-0105|FD-Score:4.65|P-value:6.90E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:3.70|P-value:2.73E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.68|P-value:2.89E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.93|P-value:1.19E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.94|P-value:1.17E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.72|P-value:2.51E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:5.03|P-value:1.29E-6 ID:SGTC_835|Compound:0312-0010|FD-Score:5.02|P-value:1.38E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.69|P-value:2.79E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.52|P-value:5.01E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.24|P-value:3.74E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.81|P-value:1.87E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.86|P-value:1.54E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.49|P-value:5.57E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.36|P-value:8.43E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.45|P-value:6.33E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-5.43|P-value:1.95E-7 ID:SGTC_1723|Compound:st034307|FD-Score:4.00|P-value:9.34E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.66|P-value:3.15E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.65|P-value:3.27E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.41|P-value:7.22E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.92|P-value:1.24E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.74|P-value:2.40E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-5.87|P-value:2.11E-8 ID:SGTC_2556|Compound:citropten|FD-Score:-3.66|P-value:3.16E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.85|P-value:1.60E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.94|P-value:1.15E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.53|P-value:4.86E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.68|P-value:2.94E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.50|P-value:1.31E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.73|P-value:2.45E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.67|P-value:3.00E-4 ID:SGTC_2975|Compound:9084847|FD-Score:5.21|P-value:5.66E-7 ID:SGTC_3207|Compound:9114163|FD-Score:4.59|P-value:8.92E-6 ID:SGTC_43|Compound:0570-0105|FD-Score:4.65|P-value:6.90E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:3.70|P-value:2.73E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.68|P-value:2.89E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.93|P-value:1.19E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.94|P-value:1.17E-4 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.72|P-value:2.51E-4 ID:SGTC_807|Compound:1315-0151|FD-Score:5.03|P-value:1.29E-6 ID:SGTC_835|Compound:0312-0010|FD-Score:5.02|P-value:1.38E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.69|P-value:2.79E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:-3.52|P-value:5.01E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.24|P-value:3.74E-5 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.81|P-value:1.87E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.86|P-value:1.54E-4 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.49|P-value:5.57E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:3.36|P-value:8.43E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.45|P-value:6.33E-4 ID:SGTC_1713|Compound:st033146|FD-Score:-5.43|P-value:1.95E-7 ID:SGTC_1723|Compound:st034307|FD-Score:4.00|P-value:9.34E-5 ID:SGTC_1895|Compound:st058434|FD-Score:3.66|P-value:3.15E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.65|P-value:3.27E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.41|P-value:7.22E-4 ID:SGTC_2334|Compound:9017922|FD-Score:3.92|P-value:1.24E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.74|P-value:2.40E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-5.87|P-value:2.11E-8 ID:SGTC_2556|Compound:citropten|FD-Score:-3.66|P-value:3.16E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.85|P-value:1.60E-4 ID:SGTC_2795|Compound:7780010|FD-Score:3.94|P-value:1.15E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-3.53|P-value:4.86E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.68|P-value:2.94E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.50|P-value:1.31E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.73|P-value:2.45E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.67|P-value:3.00E-4 ID:SGTC_2975|Compound:9084847|FD-Score:5.21|P-value:5.66E-7 ID:SGTC_3207|Compound:9114163|FD-Score:4.59|P-value:8.92E-6

Top fitness defect scores for YNR014W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2975 9084847 5.21 53.7 µM 5.66E-7 4 9.42E-8
2 SGTC_807 1315-0151 5.03 48.0 µM 1.29E-6 12 2.42E-7
3 SGTC_835 0312-0010 5.02 67.2 µM 1.38E-6 3 2.61E-7
4 SGTC_43 0570-0105 4.65 72.5 µM 6.90E-6 ERG2 62 1.63E-6
5 SGTC_3207 9114163 4.59 49.5 µM 8.92E-6 16 2.19E-6
6 SGTC_2957 9076800 4.50 11.5 µM 1.31E-5 16 3.39E-6
7 SGTC_1060 3448-7350 4.24 82.0 µM 3.74E-5 Golgi 27 1.12E-5
8 SGTC_1723 st034307 4.00 2.5 µM 9.34E-5 mitochondrial processes 29 3.17E-5
9 SGTC_2795 7780010 3.94 54.5 µM 1.15E-4 29 4.01E-5
10 SGTC_624 k048-0052 3.94 28.0 µM 1.17E-4 Golgi 15 4.10E-5
11 SGTC_451 chloral hydrate 3.93 100.0 µM 1.19E-4 51 4.18E-5
12 SGTC_2334 9017922 3.92 200.0 µM 1.24E-4 25 4.38E-5
13 SGTC_1182 1222-0449 3.86 220.0 µM 1.54E-4 21 5.58E-5
14 SGTC_2592 piperlongumine 3.85 83.3 µM 1.60E-4 TSC3-RPN4 42 5.84E-5
15 SGTC_1150 3909-7983 3.81 10.9 µM 1.87E-4 29 6.99E-5
16 SGTC_2349 9023730 3.74 187.1 µM 2.40E-4 29 9.26E-5
17 SGTC_2963 9082507 3.73 9.0 µM 2.45E-4 31 9.47E-5
18 SGTC_280 3448-3607 3.70 3.0 µM 2.73E-4 60S ribosome export 13 1.07E-4
19 SGTC_1029 k015-0030 3.69 64.7 µM 2.79E-4 36 1.10E-4
20 SGTC_382 3229-0966 3.68 23.2 µM 2.89E-4 30 1.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.37E-10 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 3.36E-10 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.095 3.95E-8 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.093 6.00E-8 YGR205W TDA10 hom ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
0.090 1.74E-7 YPR176C BET2 het Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.089 2.76E-7 YER163C GCG1 hom Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle
0.088 2.89E-7 YBL070C_d YBL070C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.082 1.73E-6 YOL013W-B_d YOL013W-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element
0.081 2.93E-6 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.080 3.83E-6 YER001W MNN1 hom Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.079 5.18E-6 YPL270W MDL2 hom Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis
0.078 5.53E-6 YMR117C SPC24 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.076 9.72E-6 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.075 1.40E-5 YKL137W CMC1 hom Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif
0.074 1.63E-5 YCL028W RNQ1 hom [PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate