YNR017W / TIM23

Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel

Zygosity: Heterozygous strain
fixedexpanded
Profile for YNR017W / TIM23

Click on Significant Values for Screen Details ID:SGTC_208|Compound:k072-0098|FD-Score:-3.92|P-value:4.92E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.44|P-value:3.14E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.35|P-value:4.41E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.15|P-value:8.81E-4 ID:SGTC_510|Compound:ag-490|FD-Score:3.30|P-value:5.23E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-5.97|P-value:1.51E-9 ID:SGTC_551|Compound:k048-0028|FD-Score:4.27|P-value:1.08E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.49|P-value:2.61E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.28|P-value:5.62E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.12|P-value:9.60E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-4.21|P-value:1.44E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:3.45|P-value:3.08E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.13|P-value:2.03E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.58|P-value:1.91E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.46|P-value:2.89E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.62|P-value:1.59E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.27|P-value:5.73E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.47|P-value:2.78E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.05|P-value:2.89E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.74|P-value:5.99E-9 ID:SGTC_1905|Compound:st060207|FD-Score:3.24|P-value:6.46E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-6.51|P-value:4.97E-11 ID:SGTC_1975|Compound:st070967|FD-Score:3.37|P-value:4.12E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.23|P-value:1.29E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.22|P-value:6.95E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.34|P-value:4.46E-4 ID:SGTC_2118|Compound:5526350|FD-Score:5.61|P-value:1.27E-8 ID:SGTC_2160|Compound:5660466|FD-Score:3.82|P-value:7.47E-5 ID:SGTC_2332|Compound:7982454|FD-Score:4.02|P-value:3.26E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.25|P-value:6.19E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.68|P-value:1.26E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.75|P-value:5.48E-9 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.31|P-value:9.16E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.52|P-value:2.36E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.20|P-value:7.46E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.73|P-value:1.04E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.06|P-value:2.70E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.17|P-value:8.10E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-4.13|P-value:2.02E-5 ID:SGTC_2787|Compound:5284540|FD-Score:3.11|P-value:9.90E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.53|P-value:3.45E-6 ID:SGTC_2846|Compound:9008642|FD-Score:3.77|P-value:9.00E-5 ID:SGTC_2893|Compound:9048488|FD-Score:3.94|P-value:4.60E-5 ID:SGTC_2905|Compound:7799065|FD-Score:-3.47|P-value:2.78E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-7.68|P-value:1.21E-14 ID:SGTC_2928|Compound:9011484|FD-Score:-5.18|P-value:1.29E-7 ID:SGTC_2965|Compound:9082772|FD-Score:-5.23|P-value:1.03E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-4.15|P-value:1.84E-5 ID:SGTC_2993|Compound:9054257|FD-Score:4.06|P-value:2.79E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.83|P-value:7.13E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-4.42|P-value:5.63E-6 ID:SGTC_3067|Compound:9117431|FD-Score:3.34|P-value:4.47E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.93|P-value:4.71E-5 ID:SGTC_3173|Compound:9105693|FD-Score:-3.38|P-value:3.88E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-3.19|P-value:7.55E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.90|P-value:5.26E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-6.44|P-value:7.67E-11 ID:SGTC_3353|Compound:9151644|FD-Score:3.33|P-value:4.74E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.92|P-value:4.92E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.44|P-value:3.14E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-3.35|P-value:4.41E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.15|P-value:8.81E-4 ID:SGTC_510|Compound:ag-490|FD-Score:3.30|P-value:5.23E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-5.97|P-value:1.51E-9 ID:SGTC_551|Compound:k048-0028|FD-Score:4.27|P-value:1.08E-5 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.49|P-value:2.61E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.28|P-value:5.62E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-3.12|P-value:9.60E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:-4.21|P-value:1.44E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:3.45|P-value:3.08E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:4.13|P-value:2.03E-5 ID:SGTC_1036|Compound:k216-0215|FD-Score:-3.58|P-value:1.91E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.46|P-value:2.89E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.62|P-value:1.59E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.27|P-value:5.73E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-3.47|P-value:2.78E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-4.05|P-value:2.89E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.74|P-value:5.99E-9 ID:SGTC_1905|Compound:st060207|FD-Score:3.24|P-value:6.46E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-6.51|P-value:4.97E-11 ID:SGTC_1975|Compound:st070967|FD-Score:3.37|P-value:4.12E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-4.23|P-value:1.29E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.22|P-value:6.95E-4 ID:SGTC_2100|Compound:5377183|FD-Score:3.34|P-value:4.46E-4 ID:SGTC_2118|Compound:5526350|FD-Score:5.61|P-value:1.27E-8 ID:SGTC_2160|Compound:5660466|FD-Score:3.82|P-value:7.47E-5 ID:SGTC_2332|Compound:7982454|FD-Score:4.02|P-value:3.26E-5 ID:SGTC_2394|Compound:5221648|FD-Score:3.25|P-value:6.19E-4 ID:SGTC_2400|Compound:5203494|FD-Score:-3.68|P-value:1.26E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-5.75|P-value:5.48E-9 ID:SGTC_2418|Compound:pentamidine|FD-Score:-4.31|P-value:9.16E-6 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.52|P-value:2.36E-4 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.20|P-value:7.46E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.73|P-value:1.04E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.06|P-value:2.70E-5 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.17|P-value:8.10E-4 ID:SGTC_2781|Compound:5567276|FD-Score:-4.13|P-value:2.02E-5 ID:SGTC_2787|Compound:5284540|FD-Score:3.11|P-value:9.90E-4 ID:SGTC_2838|Compound:9002687|FD-Score:4.53|P-value:3.45E-6 ID:SGTC_2846|Compound:9008642|FD-Score:3.77|P-value:9.00E-5 ID:SGTC_2893|Compound:9048488|FD-Score:3.94|P-value:4.60E-5 ID:SGTC_2905|Compound:7799065|FD-Score:-3.47|P-value:2.78E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-7.68|P-value:1.21E-14 ID:SGTC_2928|Compound:9011484|FD-Score:-5.18|P-value:1.29E-7 ID:SGTC_2965|Compound:9082772|FD-Score:-5.23|P-value:1.03E-7 ID:SGTC_2980|Compound:9014342|FD-Score:-4.15|P-value:1.84E-5 ID:SGTC_2993|Compound:9054257|FD-Score:4.06|P-value:2.79E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.83|P-value:7.13E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-4.42|P-value:5.63E-6 ID:SGTC_3067|Compound:9117431|FD-Score:3.34|P-value:4.47E-4 ID:SGTC_3081|Compound:9117243|FD-Score:3.93|P-value:4.71E-5 ID:SGTC_3173|Compound:9105693|FD-Score:-3.38|P-value:3.88E-4 ID:SGTC_3235|Compound:9132602|FD-Score:-3.19|P-value:7.55E-4 ID:SGTC_3350|Compound:9150499|FD-Score:-3.90|P-value:5.26E-5 ID:SGTC_3351|Compound:9150312|FD-Score:-6.44|P-value:7.67E-11 ID:SGTC_3353|Compound:9151644|FD-Score:3.33|P-value:4.74E-4

Top fitness defect scores for YNR017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2118 5526350 5.61 200.0 µM 1.27E-8 1 1.03E-8 0.70
2 SGTC_2838 9002687 4.53 71.4 µM 3.45E-6 fatty acid desaturase (OLE1) 10 3.00E-6 0.08
3 SGTC_551 k048-0028 4.27 34.9 µM 1.08E-5 5 9.58E-6 0.10
4 SGTC_1035 k081-0041 4.13 55.2 µM 2.03E-5 Golgi 5 1.81E-5 0.01
5 SGTC_2757 clomiphene 4.06 4.2 µM 2.70E-5 fatty acid desaturase (OLE1) 10 2.42E-5 0.12
6 SGTC_2993 9054257 4.06 71.4 µM 2.79E-5 fatty acid desaturase (OLE1) 29 2.49E-5 0.07
7 SGTC_2332 7982454 4.02 138.9 µM 3.26E-5 11 2.92E-5 0.41
8 SGTC_2893 9048488 3.94 26.0 µM 4.60E-5 fatty acid desaturase (OLE1) 11 4.14E-5 0.02
9 SGTC_3081 9117243 3.93 49.5 µM 4.71E-5 fatty acid desaturase (OLE1) 27 4.24E-5 0.00
10 SGTC_2160 5660466 3.82 132.9 µM 7.47E-5 60S ribosome export 16 6.76E-5 0.03
11 SGTC_2846 9008642 3.77 19.5 µM 9.00E-5 8 8.17E-5 0.05
12 SGTC_2725 haloperidol 3.73 53.2 µM 1.04E-4 plasma membrane duress 20 9.43E-5 0.03
13 SGTC_1230 0170-0365 3.62 3.8 µM 1.59E-4 endomembrane recycling 26 1.45E-4 0.08
14 SGTC_2597 laccaic acid a 3.52 100.0 µM 2.36E-4 9 2.17E-4 0.04
15 SGTC_1214 0358-0031 3.46 63.7 µM 2.89E-4 12 2.66E-4 0.19
16 SGTC_909 3448-9333 3.45 149.0 µM 3.08E-4 4 2.83E-4 0.23
17 SGTC_1975 st070967 3.37 30.8 µM 4.12E-4 19 3.81E-4 0.11
18 SGTC_2100 5377183 3.34 190.0 µM 4.46E-4 60S ribosome export 15 4.13E-4 0.00
19 SGTC_3067 9117431 3.34 49.5 µM 4.47E-4 14 4.14E-4 0.06
20 SGTC_3353 9151644 3.33 39.3 µM 4.74E-4 7 4.39E-4 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.266 1.43E-55 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.195 3.54E-30 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.194 6.22E-30 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.164 1.03E-21 YPR103W PRE2 het Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
0.161 6.59E-21 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.148 6.38E-18 YHR005C-A TIM10 het Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
0.143 1.06E-16 YER022W SRB4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination
0.126 2.40E-13 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.125 4.38E-13 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.123 8.31E-13 YAL003W EFB1 het Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
0.122 1.41E-12 YMR314W PRE5 het Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.119 4.17E-12 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.119 4.79E-12 YDL165W CDC36 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.118 6.09E-12 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.118 6.09E-12 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle