YNR020C / ATP23

Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR020C / ATP23

Click on Significant Values for Screen Details ID:SGTC_80|Compound:0159-0065|FD-Score:-3.37|P-value:9.77E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:14.20|P-value:4.00E-39 ID:SGTC_311|Compound:1315-0136|FD-Score:3.57|P-value:5.15E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:5.74|P-value:6.95E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:3.59|P-value:4.85E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.45|P-value:7.57E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:4.53|P-value:1.62E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:3.67|P-value:3.81E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.93|P-value:1.51E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:6.65|P-value:5.25E-10 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.82|P-value:2.28E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.70|P-value:3.45E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.76|P-value:2.77E-4 ID:SGTC_1713|Compound:st033146|FD-Score:4.32|P-value:3.58E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.40|P-value:8.96E-4 ID:SGTC_1990|Compound:st072050|FD-Score:4.41|P-value:2.52E-5 ID:SGTC_2004|Compound:4023728|FD-Score:-3.39|P-value:9.24E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.58|P-value:1.28E-5 ID:SGTC_2023|Compound:5144124|FD-Score:4.81|P-value:4.97E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.58|P-value:5.13E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.77|P-value:2.72E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.58|P-value:4.99E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.55|P-value:5.58E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.66|P-value:9.23E-16 ID:SGTC_2692|Compound:st077426|FD-Score:-5.26|P-value:6.96E-7 ID:SGTC_2693|Compound:st077581|FD-Score:-9.67|P-value:3.51E-19 ID:SGTC_2886|Compound:9058944|FD-Score:-3.63|P-value:4.28E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.38|P-value:9.47E-4 ID:SGTC_80|Compound:0159-0065|FD-Score:-3.37|P-value:9.77E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:14.20|P-value:4.00E-39 ID:SGTC_311|Compound:1315-0136|FD-Score:3.57|P-value:5.15E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:5.74|P-value:6.95E-8 ID:SGTC_386|Compound:1509-0011|FD-Score:3.59|P-value:4.85E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:3.45|P-value:7.57E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:4.53|P-value:1.62E-5 ID:SGTC_963|Compound:1269-2853|FD-Score:3.67|P-value:3.81E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.93|P-value:1.51E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:6.65|P-value:5.25E-10 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.82|P-value:2.28E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:-3.70|P-value:3.45E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:3.76|P-value:2.77E-4 ID:SGTC_1713|Compound:st033146|FD-Score:4.32|P-value:3.58E-5 ID:SGTC_1728|Compound:st035614|FD-Score:3.40|P-value:8.96E-4 ID:SGTC_1990|Compound:st072050|FD-Score:4.41|P-value:2.52E-5 ID:SGTC_2004|Compound:4023728|FD-Score:-3.39|P-value:9.24E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.58|P-value:1.28E-5 ID:SGTC_2023|Compound:5144124|FD-Score:4.81|P-value:4.97E-6 ID:SGTC_2326|Compound:6164455|FD-Score:3.58|P-value:5.13E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.77|P-value:2.72E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.58|P-value:4.99E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-3.55|P-value:5.58E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.66|P-value:9.23E-16 ID:SGTC_2692|Compound:st077426|FD-Score:-5.26|P-value:6.96E-7 ID:SGTC_2693|Compound:st077581|FD-Score:-9.67|P-value:3.51E-19 ID:SGTC_2886|Compound:9058944|FD-Score:-3.63|P-value:4.28E-4 ID:SGTC_2956|Compound:9076196|FD-Score:3.38|P-value:9.47E-4

Top fitness defect scores for YNR020C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 14.20 5.3 µM 4.00E-39 114 5.00E-46
2 SGTC_2688 kanamycin b 8.66 96.7 µM 9.23E-16 calcium & mitochondrial duress 48 2.36E-18
3 SGTC_1057 3448-5381 6.65 134.0 µM 5.25E-10 calcium & mitochondrial duress 6 1.51E-11
4 SGTC_385 1494-0393 5.74 12.4 µM 6.95E-8 2 4.85E-9
5 SGTC_2023 5144124 4.81 124.0 µM 4.97E-6 12 7.46E-7
6 SGTC_2018 5133068 4.58 143.0 µM 1.28E-5 10 2.29E-6
7 SGTC_962 1254-0300 4.53 21.5 µM 1.62E-5 12 3.01E-6
8 SGTC_1990 st072050 4.41 59.8 µM 2.52E-5 10 5.06E-6
9 SGTC_1713 st033146 4.32 12.8 µM 3.58E-5 19 7.63E-6
10 SGTC_1046 2001-0062 3.93 216.0 µM 1.51E-4 19 4.16E-5
11 SGTC_1159 4092-0538 3.82 61.2 µM 2.28E-4 34 6.73E-5
12 SGTC_2416 tofa 3.77 880.0 nM 2.72E-4 sphingolipid biosynthesis & PDR1 57 8.29E-5
13 SGTC_1568 digitonin 3.76 820.0 nM 2.77E-4 sphingolipid biosynthesis & PDR1 39 8.45E-5
14 SGTC_963 1269-2853 3.67 151.0 µM 3.81E-4 34 1.23E-4
15 SGTC_386 1509-0011 3.59 3.1 µM 4.85E-4 163 1.64E-4
16 SGTC_2459 5811157 3.58 9.2 µM 4.99E-4 mitochondrial processes 24 1.69E-4
17 SGTC_2326 6164455 3.58 177.6 µM 5.13E-4 mitochondrial processes 36 1.75E-4
18 SGTC_311 1315-0136 3.57 58.0 µM 5.15E-4 17 1.75E-4
19 SGTC_539 4859-0462 3.45 2.5 µM 7.57E-4 RNA pol III & RNase P/MRP 41 2.76E-4
20 SGTC_1728 st035614 3.40 33.8 µM 8.96E-4 82 3.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.419 5.25E-143 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.415 1.47E-139 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.409 2.04E-135 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.403 5.22E-131 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.377 7.84E-114 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.376 9.67E-113 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.370 4.53E-109 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.367 2.60E-107 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.358 7.55E-102 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.354 9.70E-100 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.353 8.11E-99 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.352 1.81E-98 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.352 1.71E-98 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.346 6.84E-95 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.345 1.76E-94 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit