HIPHOP chemogenomics database

YNR020C / ATP23

Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p

Zygosity: Homozygous strain

fixedexpanded
Profile for YNR020C / ATP23

Click on Significant Values for Screen Details

Top fitness defect scores for YNR020C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	14.20	5.3 µM	4.00E-39		114	5.00E-46
2	SGTC_2688	kanamycin b	8.66	96.7 µM	9.23E-16	calcium & mitochondrial duress	48	2.36E-18
3	SGTC_1057	3448-5381	6.65	134.0 µM	5.25E-10	calcium & mitochondrial duress	6	1.51E-11
4	SGTC_385	1494-0393	5.74	12.4 µM	6.95E-8		2	4.85E-9
5	SGTC_2023	5144124	4.81	124.0 µM	4.97E-6		12	7.46E-7
6	SGTC_2018	5133068	4.58	143.0 µM	1.28E-5		10	2.29E-6
7	SGTC_962	1254-0300	4.53	21.5 µM	1.62E-5		12	3.01E-6
8	SGTC_1990	st072050	4.41	59.8 µM	2.52E-5		10	5.06E-6
9	SGTC_1713	st033146	4.32	12.8 µM	3.58E-5		19	7.63E-6
10	SGTC_1046	2001-0062	3.93	216.0 µM	1.51E-4		19	4.16E-5
11	SGTC_1159	4092-0538	3.82	61.2 µM	2.28E-4		34	6.73E-5
12	SGTC_2416	tofa	3.77	880.0 nM	2.72E-4	sphingolipid biosynthesis & PDR1	57	8.29E-5
13	SGTC_1568	digitonin	3.76	820.0 nM	2.77E-4	sphingolipid biosynthesis & PDR1	39	8.45E-5
14	SGTC_963	1269-2853	3.67	151.0 µM	3.81E-4		34	1.23E-4
15	SGTC_386	1509-0011	3.59	3.1 µM	4.85E-4		163	1.64E-4
16	SGTC_2459	5811157	3.58	9.2 µM	4.99E-4	mitochondrial processes	24	1.69E-4
17	SGTC_2326	6164455	3.58	177.6 µM	5.13E-4	mitochondrial processes	36	1.75E-4
18	SGTC_311	1315-0136	3.57	58.0 µM	5.15E-4		17	1.75E-4
19	SGTC_539	4859-0462	3.45	2.5 µM	7.57E-4	RNA pol III & RNase P/MRP	41	2.76E-4
20	SGTC_1728	st035614	3.40	33.8 µM	8.96E-4		82	3.36E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.419	5.25E-143	YHR050W-A_p	YHR050W-A_p	hom	Protein of unknown function; identified by expression profiling and mass spectrometry
0.415	1.47E-139	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.409	2.04E-135	YJR120W	YJR120W	hom	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.403	5.22E-131	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.377	7.84E-114	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.376	9.67E-113	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.370	4.53E-109	YGL237C	HAP2	hom	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.367	2.60E-107	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.358	7.55E-102	YHR116W	COX23	hom	Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.354	9.70E-100	YGL107C	RMD9	hom	Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.353	8.11E-99	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.352	1.81E-98	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.352	1.71E-98	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.346	6.84E-95	YJL022W_d	YJL022W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.345	1.76E-94	YMR286W	MRPL33	hom	Mitochondrial ribosomal protein of the large subunit