YNR021W_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR021W / YNR021W

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:3.23|P-value:2.64E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.35|P-value:4.35E-12 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.93|P-value:1.04E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:2.98|P-value:6.92E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.58|P-value:6.07E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:2.95|P-value:7.81E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.73|P-value:1.58E-7 ID:SGTC_429|Compound:1112-0049|FD-Score:-2.97|P-value:6.40E-4 ID:SGTC_469|Compound:w7|FD-Score:-2.97|P-value:6.38E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.47|P-value:7.77E-7 ID:SGTC_657|Compound:3534-0529|FD-Score:3.26|P-value:2.32E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.62|P-value:4.41E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:-2.89|P-value:8.72E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.21|P-value:2.84E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.77|P-value:2.59E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.29|P-value:1.82E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:2.88|P-value:9.87E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:2.96|P-value:7.44E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.63|P-value:4.81E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.28|P-value:2.19E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.22|P-value:2.97E-6 ID:SGTC_1747|Compound:st037496|FD-Score:-3.38|P-value:1.27E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.03|P-value:5.78E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.87|P-value:1.38E-5 ID:SGTC_2301|Compound:7769476|FD-Score:-2.89|P-value:8.53E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.15|P-value:3.27E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.50|P-value:7.53E-5 ID:SGTC_2402|Compound:5553605|FD-Score:3.68|P-value:3.82E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.59|P-value:5.14E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.75|P-value:2.42E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.64|P-value:4.61E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-3.66|P-value:3.68E-5 ID:SGTC_2970|Compound:9090938|FD-Score:4.16|P-value:4.00E-6 ID:SGTC_2986|Compound:9022445|FD-Score:3.03|P-value:5.71E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.52|P-value:7.88E-5 ID:SGTC_3301|Compound:9125354|FD-Score:-3.37|P-value:1.29E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.43|P-value:1.01E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.23|P-value:2.64E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.35|P-value:4.35E-12 ID:SGTC_177|Compound:1327-0068|FD-Score:-3.93|P-value:1.04E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:2.98|P-value:6.92E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.58|P-value:6.07E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:2.95|P-value:7.81E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.73|P-value:1.58E-7 ID:SGTC_429|Compound:1112-0049|FD-Score:-2.97|P-value:6.40E-4 ID:SGTC_469|Compound:w7|FD-Score:-2.97|P-value:6.38E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.47|P-value:7.77E-7 ID:SGTC_657|Compound:3534-0529|FD-Score:3.26|P-value:2.32E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.62|P-value:4.41E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:-2.89|P-value:8.72E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.21|P-value:2.84E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.77|P-value:2.59E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.29|P-value:1.82E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:2.88|P-value:9.87E-4 ID:SGTC_1166|Compound:k206-0078|FD-Score:2.96|P-value:7.44E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:3.63|P-value:4.81E-5 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.28|P-value:2.19E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.22|P-value:2.97E-6 ID:SGTC_1747|Compound:st037496|FD-Score:-3.38|P-value:1.27E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.03|P-value:5.78E-4 ID:SGTC_2294|Compound:7971431|FD-Score:-3.87|P-value:1.38E-5 ID:SGTC_2301|Compound:7769476|FD-Score:-2.89|P-value:8.53E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.15|P-value:3.27E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-3.50|P-value:7.53E-5 ID:SGTC_2402|Compound:5553605|FD-Score:3.68|P-value:3.82E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:-3.59|P-value:5.14E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:-3.75|P-value:2.42E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:3.64|P-value:4.61E-5 ID:SGTC_2813|Compound:7971799|FD-Score:-3.66|P-value:3.68E-5 ID:SGTC_2970|Compound:9090938|FD-Score:4.16|P-value:4.00E-6 ID:SGTC_2986|Compound:9022445|FD-Score:3.03|P-value:5.71E-4 ID:SGTC_3010|Compound:9080089|FD-Score:3.52|P-value:7.88E-5 ID:SGTC_3301|Compound:9125354|FD-Score:-3.37|P-value:1.29E-4 ID:SGTC_3304|Compound:9125678|FD-Score:-3.43|P-value:1.01E-4

Top fitness defect scores for YNR021W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 6.35 51.8 µM 4.35E-12 ERAD & cell cycle 71 1.10E-10
2 SGTC_556 4058-0063 4.47 51.5 µM 7.77E-7 18 3.89E-6
3 SGTC_1716 st033144 4.22 30.6 µM 2.97E-6 15 1.25E-5
4 SGTC_2970 9090938 4.16 41.9 µM 4.00E-6 RNA processing & uracil transport 32 1.62E-5
5 SGTC_1106 tegaserod maleate 3.77 11.7 µM 2.59E-5 26 8.18E-5
6 SGTC_2402 5553605 3.68 200.0 µM 3.82E-5 37 1.15E-4
7 SGTC_2584 androsterone 3.64 48.7 µM 4.61E-5 cell wall 146 1.35E-4
8 SGTC_1258 0671-0043 3.63 57.1 µM 4.81E-5 36 1.40E-4
9 SGTC_188 3229-0966 3.58 278.5 µM 6.07E-5 35 1.72E-4
10 SGTC_3010 9080089 3.52 71.4 µM 7.88E-5 25 2.16E-4
11 SGTC_1259 0671-0132 3.28 43.0 µM 2.19E-4 54 5.27E-4
12 SGTC_657 3534-0529 3.26 86.7 µM 2.32E-4 30 5.53E-4
13 SGTC_61 0978-8327 3.23 98.6 µM 2.64E-4 ergosterol biosynthesis 58 6.19E-4
14 SGTC_1012 4112-3522 3.21 18.0 µM 2.84E-4 46 6.61E-4
15 SGTC_2986 9022445 3.03 71.4 µM 5.71E-4 53 0.00121
16 SGTC_1938 st074717 3.03 56.4 µM 5.78E-4 37 0.00123
17 SGTC_184 1494-0393 2.98 24.7 µM 6.92E-4 114 0.00144
18 SGTC_1166 k206-0078 2.96 225.0 µM 7.44E-4 63 0.00153
19 SGTC_286 k060-0067 2.95 22.9 µM 7.81E-4 tubulin folding & SWR complex 55 0.00160
20 SGTC_1157 4092-0394 2.88 27.6 µM 9.87E-4 92 0.00196

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 5.80E-27 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.166 4.93E-22 YDL122W UBP1 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
0.158 4.38E-20 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.141 2.11E-16 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication
0.134 7.18E-15 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication
0.126 2.45E-13 YMR276W DSK2 hom Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress
0.125 4.19E-13 YER027C GAL83 hom One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain
0.123 8.77E-13 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.120 3.52E-12 YBR085C-A YBR085C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress
0.120 3.70E-12 YKL031W_d YKL031W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
0.119 4.81E-12 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.118 5.78E-12 YPL117C IDI1 het Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
0.118 5.91E-12 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.117 8.82E-12 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.115 2.23E-11 YNL149C PGA2 het Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect