YNR025C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR025C / YNR025C

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:3.77|P-value:3.52E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:4.71|P-value:3.33E-7 ID:SGTC_180|Compound:1486-1293|FD-Score:3.51|P-value:1.10E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.36|P-value:2.01E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.65|P-value:6.06E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:3.90|P-value:1.93E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.14|P-value:3.71E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.84|P-value:2.62E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.90|P-value:1.95E-5 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.08|P-value:4.73E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.76|P-value:2.69E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.12|P-value:4.02E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.09|P-value:4.49E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:4.06|P-value:9.34E-6 ID:SGTC_500|Compound:h-89|FD-Score:3.11|P-value:5.31E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.16|P-value:3.48E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:5.29|P-value:1.13E-8 ID:SGTC_756|Compound:0508-1999|FD-Score:4.01|P-value:1.15E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:4.24|P-value:3.79E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:4.37|P-value:1.97E-6 ID:SGTC_881|Compound:0833-0569|FD-Score:3.00|P-value:8.06E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.25|P-value:3.07E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.02|P-value:7.43E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:5.27|P-value:1.25E-8 ID:SGTC_934|Compound:2950-0684|FD-Score:3.82|P-value:2.88E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:5.79|P-value:4.66E-10 ID:SGTC_938|Compound:3126-1755|FD-Score:3.79|P-value:3.22E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.36|P-value:1.56E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.95|P-value:8.55E-8 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.18|P-value:3.21E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.36|P-value:2.04E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.47|P-value:1.29E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.04|P-value:7.01E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.04|P-value:6.91E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.16|P-value:4.46E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.05|P-value:6.72E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-2.93|P-value:8.15E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.02|P-value:7.45E-4 ID:SGTC_1644|Compound:st010134|FD-Score:4.11|P-value:7.23E-6 ID:SGTC_1659|Compound:st012954|FD-Score:3.31|P-value:2.48E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.22|P-value:3.52E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.53|P-value:9.94E-5 ID:SGTC_2104|Compound:5389443|FD-Score:-5.48|P-value:2.34E-9 ID:SGTC_2113|Compound:5491891|FD-Score:-3.55|P-value:6.80E-5 ID:SGTC_2117|Compound:5521686|FD-Score:4.35|P-value:2.18E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.28|P-value:2.78E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.57|P-value:8.59E-5 ID:SGTC_2191|Compound:5911152|FD-Score:3.39|P-value:1.76E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.33|P-value:2.30E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.78|P-value:3.40E-5 ID:SGTC_2452|Compound:5863136|FD-Score:-2.88|P-value:9.69E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.47|P-value:1.30E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.67|P-value:4.19E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.41|P-value:1.25E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-5.40|P-value:3.89E-9 ID:SGTC_2835|Compound:9006588|FD-Score:4.52|P-value:8.99E-7 ID:SGTC_2981|Compound:9013952|FD-Score:-4.78|P-value:1.54E-7 ID:SGTC_3038|Compound:9091290|FD-Score:3.97|P-value:1.39E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.09|P-value:5.77E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.42|P-value:1.60E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.02|P-value:7.38E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.77|P-value:3.52E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:4.71|P-value:3.33E-7 ID:SGTC_180|Compound:1486-1293|FD-Score:3.51|P-value:1.10E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.36|P-value:2.01E-4 ID:SGTC_210|Compound:3551-0445|FD-Score:3.65|P-value:6.06E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:3.90|P-value:1.93E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.14|P-value:3.71E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.84|P-value:2.62E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:3.90|P-value:1.95E-5 ID:SGTC_399|Compound:oxolinic acid|FD-Score:-3.08|P-value:4.73E-4 ID:SGTC_401|Compound:neomycin|FD-Score:-3.76|P-value:2.69E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:-3.12|P-value:4.02E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.09|P-value:4.49E-4 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:4.06|P-value:9.34E-6 ID:SGTC_500|Compound:h-89|FD-Score:3.11|P-value:5.31E-4 ID:SGTC_572|Compound:0960-0087|FD-Score:-3.16|P-value:3.48E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:5.29|P-value:1.13E-8 ID:SGTC_756|Compound:0508-1999|FD-Score:4.01|P-value:1.15E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:4.24|P-value:3.79E-6 ID:SGTC_870|Compound:0573-2213|FD-Score:4.37|P-value:1.97E-6 ID:SGTC_881|Compound:0833-0569|FD-Score:3.00|P-value:8.06E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:3.25|P-value:3.07E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:3.02|P-value:7.43E-4 ID:SGTC_930|Compound:2810-3379|FD-Score:5.27|P-value:1.25E-8 ID:SGTC_934|Compound:2950-0684|FD-Score:3.82|P-value:2.88E-5 ID:SGTC_937|Compound:3122-0005|FD-Score:5.79|P-value:4.66E-10 ID:SGTC_938|Compound:3126-1755|FD-Score:3.79|P-value:3.22E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:-3.36|P-value:1.56E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.95|P-value:8.55E-8 ID:SGTC_1319|Compound:1306-0155|FD-Score:-3.18|P-value:3.21E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.36|P-value:2.04E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.47|P-value:1.29E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:3.04|P-value:7.01E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:3.04|P-value:6.91E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.16|P-value:4.46E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:3.05|P-value:6.72E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:-2.93|P-value:8.15E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.02|P-value:7.45E-4 ID:SGTC_1644|Compound:st010134|FD-Score:4.11|P-value:7.23E-6 ID:SGTC_1659|Compound:st012954|FD-Score:3.31|P-value:2.48E-4 ID:SGTC_2011|Compound:4012611|FD-Score:3.22|P-value:3.52E-4 ID:SGTC_2033|Compound:5192550|FD-Score:3.53|P-value:9.94E-5 ID:SGTC_2104|Compound:5389443|FD-Score:-5.48|P-value:2.34E-9 ID:SGTC_2113|Compound:5491891|FD-Score:-3.55|P-value:6.80E-5 ID:SGTC_2117|Compound:5521686|FD-Score:4.35|P-value:2.18E-6 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.28|P-value:2.78E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.57|P-value:8.59E-5 ID:SGTC_2191|Compound:5911152|FD-Score:3.39|P-value:1.76E-4 ID:SGTC_2261|Compound:9010538|FD-Score:3.33|P-value:2.30E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.78|P-value:3.40E-5 ID:SGTC_2452|Compound:5863136|FD-Score:-2.88|P-value:9.69E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:3.47|P-value:1.30E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:-3.67|P-value:4.19E-5 ID:SGTC_2812|Compound:7970281|FD-Score:-3.41|P-value:1.25E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-5.40|P-value:3.89E-9 ID:SGTC_2835|Compound:9006588|FD-Score:4.52|P-value:8.99E-7 ID:SGTC_2981|Compound:9013952|FD-Score:-4.78|P-value:1.54E-7 ID:SGTC_3038|Compound:9091290|FD-Score:3.97|P-value:1.39E-5 ID:SGTC_3067|Compound:9117431|FD-Score:3.09|P-value:5.77E-4 ID:SGTC_3113|Compound:9123498|FD-Score:3.42|P-value:1.60E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.02|P-value:7.38E-4

Top fitness defect scores for YNR025C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_937 3122-0005 5.79 46.7 µM 4.66E-10 7 3.57E-9
2 SGTC_617 3770-0098 5.29 35.0 µM 1.13E-8 exosome 6 6.13E-8
3 SGTC_930 2810-3379 5.27 265.0 µM 1.25E-8 1 6.70E-8
4 SGTC_1133 3473-0247 4.95 50.0 µM 8.55E-8 RSC complex & mRNA processing 21 3.74E-7
5 SGTC_178 4092-0806 4.71 87.5 µM 3.33E-7 ergosterol depletion effects on membrane 62 1.26E-6
6 SGTC_2835 9006588 4.52 71.4 µM 8.99E-7 27 3.06E-6
7 SGTC_870 0573-2213 4.37 57.6 µM 1.97E-6 ERG2 12 6.17E-6
8 SGTC_2117 5521686 4.35 200.0 µM 2.18E-6 8 6.75E-6
9 SGTC_858 0438-0351 4.24 2.8 µM 3.79E-6 copper-dependent oxidative stress 15 1.11E-5
10 SGTC_1644 st010134 4.11 20.9 µM 7.23E-6 mitochondrial processes 12 1.98E-5
11 SGTC_414 piperonyl butoxide 4.06 100.0 µM 9.34E-6 5 2.48E-5
12 SGTC_756 0508-1999 4.01 28.3 µM 1.15E-5 RPP1 & pyrimidine depletion 22 3.00E-5
13 SGTC_3038 9091290 3.97 49.5 µM 1.39E-5 13 3.55E-5
14 SGTC_362 0310-0100 3.90 9.0 µM 1.93E-5 RPP1 & pyrimidine depletion 35 4.75E-5
15 SGTC_382 3229-0966 3.90 23.2 µM 1.95E-5 22 4.81E-5
16 SGTC_369 0957-0393 3.84 4.5 µM 2.62E-5 cell wall signaling 27 6.26E-5
17 SGTC_934 2950-0684 3.82 338.0 µM 2.88E-5 25 6.80E-5
18 SGTC_938 3126-1755 3.79 342.0 µM 3.22E-5 14 7.52E-5
19 SGTC_2282 7944268 3.78 200.0 µM 3.40E-5 RPP1 & pyrimidine depletion 37 7.91E-5
20 SGTC_87 0100-0052 3.77 35.5 µM 3.52E-5 120 8.16E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 6.19E-19 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.129 5.20E-14 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.126 2.13E-13 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.109 2.28E-10 YDR510W SMT3 het Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
0.105 9.51E-10 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.096 2.44E-8 YDR026C NSI1 hom RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication
0.096 2.79E-8 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.091 1.34E-7 YDR308C SRB7 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
0.090 1.88E-7 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.089 2.57E-7 YBR277C_d YBR277C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W
0.087 4.54E-7 YIL146C ATG32 hom Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane
0.086 6.83E-7 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.081 2.89E-6 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.080 3.33E-6 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.080 3.52E-6 YDL167C NRP1 hom Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis