YNR028W / CPR8

Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR028W / CPR8

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-4.46|P-value:1.27E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.12|P-value:4.26E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:2.91|P-value:9.43E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.16|P-value:3.74E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.34|P-value:1.85E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:3.33|P-value:1.93E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.71|P-value:3.78E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:3.47|P-value:1.09E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.35|P-value:1.77E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:4.03|P-value:8.75E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.94|P-value:1.63E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:2.96|P-value:7.84E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.20|P-value:3.80E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.16|P-value:4.70E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.66|P-value:4.44E-7 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.97|P-value:7.62E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.80|P-value:1.58E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.62|P-value:5.69E-5 ID:SGTC_1668|Compound:st014914|FD-Score:-3.19|P-value:3.96E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.11|P-value:4.54E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-3.07|P-value:6.32E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.75|P-value:3.23E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.07|P-value:6.29E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.06|P-value:6.57E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.01|P-value:7.70E-4 ID:SGTC_2117|Compound:5521686|FD-Score:2.92|P-value:9.19E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-5.72|P-value:7.69E-10 ID:SGTC_2140|Compound:5586273|FD-Score:-3.56|P-value:9.03E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.38|P-value:1.56E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.08|P-value:6.81E-6 ID:SGTC_2379|Compound:9035213|FD-Score:3.35|P-value:1.78E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-2.95|P-value:9.64E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.71|P-value:4.69E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.65|P-value:4.89E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:2.99|P-value:7.05E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.37|P-value:1.61E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.99|P-value:5.55E-8 ID:SGTC_2833|Compound:9001315|FD-Score:8.38|P-value:2.66E-19 ID:SGTC_2834|Compound:9001755|FD-Score:-7.91|P-value:3.25E-17 ID:SGTC_2933|Compound:9026794|FD-Score:-3.85|P-value:2.52E-5 ID:SGTC_2942|Compound:9052777|FD-Score:2.91|P-value:9.33E-4 ID:SGTC_3240|Compound:9133527|FD-Score:-2.97|P-value:9.07E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-4.46|P-value:1.27E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:3.12|P-value:4.26E-4 ID:SGTC_189|Compound:3970-0742|FD-Score:2.91|P-value:9.43E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:3.16|P-value:3.74E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:4.34|P-value:1.85E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:3.33|P-value:1.93E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.71|P-value:3.78E-5 ID:SGTC_544|Compound:k015-0020|FD-Score:3.47|P-value:1.09E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.35|P-value:1.77E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:4.03|P-value:8.75E-6 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.94|P-value:1.63E-5 ID:SGTC_996|Compound:3970-0799|FD-Score:2.96|P-value:7.84E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:-3.20|P-value:3.80E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.16|P-value:4.70E-6 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.66|P-value:4.44E-7 ID:SGTC_1114|Compound:scopoletin|FD-Score:2.97|P-value:7.62E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.80|P-value:1.58E-7 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.62|P-value:5.69E-5 ID:SGTC_1668|Compound:st014914|FD-Score:-3.19|P-value:3.96E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.11|P-value:4.54E-4 ID:SGTC_1886|Compound:st057356|FD-Score:-3.07|P-value:6.32E-4 ID:SGTC_1891|Compound:st059073|FD-Score:3.75|P-value:3.23E-5 ID:SGTC_2003|Compound:4023581|FD-Score:-3.07|P-value:6.29E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.06|P-value:6.57E-4 ID:SGTC_2089|Compound:5281248|FD-Score:-3.01|P-value:7.70E-4 ID:SGTC_2117|Compound:5521686|FD-Score:2.92|P-value:9.19E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:-5.72|P-value:7.69E-10 ID:SGTC_2140|Compound:5586273|FD-Score:-3.56|P-value:9.03E-5 ID:SGTC_2253|Compound:7938677|FD-Score:3.38|P-value:1.56E-4 ID:SGTC_2375|Compound:9072683|FD-Score:4.08|P-value:6.81E-6 ID:SGTC_2379|Compound:9035213|FD-Score:3.35|P-value:1.78E-4 ID:SGTC_2441|Compound:5730946|FD-Score:-2.95|P-value:9.64E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.71|P-value:4.69E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.65|P-value:4.89E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:2.99|P-value:7.05E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.37|P-value:1.61E-4 ID:SGTC_2832|Compound:7992762|FD-Score:4.99|P-value:5.55E-8 ID:SGTC_2833|Compound:9001315|FD-Score:8.38|P-value:2.66E-19 ID:SGTC_2834|Compound:9001755|FD-Score:-7.91|P-value:3.25E-17 ID:SGTC_2933|Compound:9026794|FD-Score:-3.85|P-value:2.52E-5 ID:SGTC_2942|Compound:9052777|FD-Score:2.91|P-value:9.33E-4 ID:SGTC_3240|Compound:9133527|FD-Score:-2.97|P-value:9.07E-4

Top fitness defect scores for YNR028W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2833 9001315 8.38 45.5 µM 2.66E-19 amide catabolism 5 2.61E-17
2 SGTC_2832 7992762 4.99 52.0 µM 5.55E-8 11 3.08E-7
3 SGTC_1122 capsaicin 4.80 818.6 nM 1.58E-7 14 7.82E-7
4 SGTC_359 0081-0058 4.34 15.9 µM 1.85E-6 60S ribosome export 31 7.00E-6
5 SGTC_1033 k072-0102 4.16 21.3 µM 4.70E-6 60S ribosome export 16 1.61E-5
6 SGTC_2375 9072683 4.08 200.0 µM 6.81E-6 mitochondrial processes 17 2.23E-5
7 SGTC_847 0342-0274 4.03 5.5 µM 8.75E-6 17 2.79E-5
8 SGTC_1891 st059073 3.75 26.2 µM 3.23E-5 TSC3-RPN4 26 8.93E-5
9 SGTC_515 4092-1064 3.71 102.0 µM 3.78E-5 plasma membrane duress 66 1.03E-4
10 SGTC_2589 lobaric acid 3.65 100.0 µM 4.89E-5 31 1.29E-4
11 SGTC_1134 3477-0009 3.62 42.5 µM 5.69E-5 55 1.48E-4
12 SGTC_544 k015-0020 3.47 52.4 µM 1.09E-4 21 2.64E-4
13 SGTC_2253 7938677 3.38 135.8 µM 1.56E-4 28 3.63E-4
14 SGTC_2821 7996764 3.37 71.4 µM 1.61E-4 62 3.73E-4
15 SGTC_669 0108-0021 3.35 26.2 µM 1.77E-4 fatty acid desaturase (OLE1) 122 4.07E-4
16 SGTC_2379 9035213 3.35 200.0 µM 1.78E-4 46 4.08E-4
17 SGTC_368 fentichlor 3.33 4.6 µM 1.93E-4 46 4.39E-4
18 SGTC_201 4262-0159 3.16 12.8 µM 3.74E-4 ergosterol depletion effects on membrane 74 7.92E-4
19 SGTC_188 3229-0966 3.12 278.5 µM 4.26E-4 75 8.92E-4
20 SGTC_1779 st039427 3.11 55.0 µM 4.54E-4 66 9.44E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 2.46E-48 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.198 7.18E-31 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.195 5.75E-30 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.191 4.74E-29 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.184 4.97E-27 YDL012C YDL012C hom Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication
0.173 4.19E-24 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.166 5.07E-22 YKL168C KKQ8 hom Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication
0.165 7.39E-22 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.162 4.79E-21 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.161 6.49E-21 YER176W ECM32 hom DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
0.160 1.22E-20 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.157 5.93E-20 YMR122C_d YMR122C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.154 3.08E-19 YJR108W ABM1 hom Protein of unknown function, required for normal microtubule organization
0.151 1.48E-18 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.150 2.85E-18 YJR130C STR2 hom Cystathionine gamma-synthase, converts cysteine into cystathionine