YNR033W / ABZ1

Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR033W / ABZ1

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:-4.18|P-value:1.48E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:3.18|P-value:1.87E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.44|P-value:6.04E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:5.59|P-value:2.00E-10 ID:SGTC_702|Compound:1488-0190|FD-Score:2.80|P-value:8.52E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.05|P-value:3.19E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:11.10|P-value:1.47E-35 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.31|P-value:1.07E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:2.92|P-value:5.46E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.84|P-value:7.63E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.37|P-value:8.27E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.20|P-value:3.07E-9 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.96|P-value:4.64E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.81|P-value:1.01E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:2.93|P-value:5.34E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:2.90|P-value:5.82E-4 ID:SGTC_2119|Compound:5528445|FD-Score:2.78|P-value:9.39E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.06|P-value:3.09E-4 ID:SGTC_2308|Compound:7584454|FD-Score:5.15|P-value:4.35E-9 ID:SGTC_2310|Compound:7668677|FD-Score:8.22|P-value:1.92E-20 ID:SGTC_2315|Compound:7733312|FD-Score:-4.32|P-value:6.81E-7 ID:SGTC_2570|Compound:licareol|FD-Score:4.26|P-value:9.56E-7 ID:SGTC_2623|Compound:humulene|FD-Score:-2.81|P-value:8.54E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.31|P-value:1.08E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.24|P-value:1.46E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.11|P-value:2.54E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.15|P-value:2.13E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.61|P-value:2.74E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.50|P-value:4.56E-5 ID:SGTC_3006|Compound:9075424|FD-Score:3.22|P-value:1.60E-4 ID:SGTC_3011|Compound:9081274|FD-Score:2.97|P-value:4.49E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-3.06|P-value:3.14E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.46|P-value:5.63E-5 ID:SGTC_3195|Compound:9113082|FD-Score:3.04|P-value:3.40E-4 ID:SGTC_3245|Compound:9134821|FD-Score:2.78|P-value:9.37E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.35|P-value:8.84E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:-4.18|P-value:1.48E-6 ID:SGTC_431|Compound:k089-0097|FD-Score:3.18|P-value:1.87E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:3.44|P-value:6.04E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:5.59|P-value:2.00E-10 ID:SGTC_702|Compound:1488-0190|FD-Score:2.80|P-value:8.52E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.05|P-value:3.19E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:11.10|P-value:1.47E-35 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.31|P-value:1.07E-4 ID:SGTC_1126|Compound:isoteolin|FD-Score:2.92|P-value:5.46E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:-2.84|P-value:7.63E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.37|P-value:8.27E-5 ID:SGTC_1171|Compound:0368-0077|FD-Score:5.20|P-value:3.07E-9 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.96|P-value:4.64E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.81|P-value:1.01E-5 ID:SGTC_1467|Compound:k284-1082|FD-Score:2.93|P-value:5.34E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:2.90|P-value:5.82E-4 ID:SGTC_2119|Compound:5528445|FD-Score:2.78|P-value:9.39E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.06|P-value:3.09E-4 ID:SGTC_2308|Compound:7584454|FD-Score:5.15|P-value:4.35E-9 ID:SGTC_2310|Compound:7668677|FD-Score:8.22|P-value:1.92E-20 ID:SGTC_2315|Compound:7733312|FD-Score:-4.32|P-value:6.81E-7 ID:SGTC_2570|Compound:licareol|FD-Score:4.26|P-value:9.56E-7 ID:SGTC_2623|Compound:humulene|FD-Score:-2.81|P-value:8.54E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.31|P-value:1.08E-4 ID:SGTC_2705|Compound:st078069|FD-Score:-3.24|P-value:1.46E-4 ID:SGTC_2787|Compound:5284540|FD-Score:3.11|P-value:2.54E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.15|P-value:2.13E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.61|P-value:2.74E-5 ID:SGTC_2921|Compound:7974240|FD-Score:3.50|P-value:4.56E-5 ID:SGTC_3006|Compound:9075424|FD-Score:3.22|P-value:1.60E-4 ID:SGTC_3011|Compound:9081274|FD-Score:2.97|P-value:4.49E-4 ID:SGTC_3017|Compound:9080681|FD-Score:-3.06|P-value:3.14E-4 ID:SGTC_3074|Compound:9116018|FD-Score:-3.46|P-value:5.63E-5 ID:SGTC_3195|Compound:9113082|FD-Score:3.04|P-value:3.40E-4 ID:SGTC_3245|Compound:9134821|FD-Score:2.78|P-value:9.37E-4 ID:SGTC_3278|Compound:9139605|FD-Score:3.35|P-value:8.84E-5

Top fitness defect scores for YNR033W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_996 3970-0799 11.10 1.8 µM 1.47E-35 11 7.66E-29
2 SGTC_2310 7668677 8.22 200.0 µM 1.92E-20 1 1.01E-16
3 SGTC_611 3453-1652 5.59 23.7 µM 2.00E-10 4 1.12E-8
4 SGTC_1171 0368-0077 5.20 21.4 µM 3.07E-9 8 1.01E-7
5 SGTC_2308 7584454 5.15 197.6 µM 4.35E-9 8 1.33E-7
6 SGTC_2570 licareol 4.26 100.0 µM 9.56E-7 23 1.03E-5
7 SGTC_1243 0416-0003 3.96 5.7 µM 4.64E-6 PDR1 30 3.69E-5
8 SGTC_1378 2093-0007 3.81 380.0 nM 1.01E-5 25 6.90E-5
9 SGTC_2849 9019321 3.61 13.0 µM 2.74E-5 42 1.55E-4
10 SGTC_2921 7974240 3.50 10.7 µM 4.56E-5 72 2.34E-4
11 SGTC_559 1550-0661 3.44 158.0 µM 6.04E-5 17 2.94E-4
12 SGTC_1167 k781-0610 3.37 148.0 µM 8.27E-5 RNA processing & uracil transport 48 3.79E-4
13 SGTC_3278 9139605 3.35 49.5 µM 8.84E-5 32 4.00E-4
14 SGTC_1003 4049-0218 3.31 100.0 µM 1.07E-4 42 4.67E-4
15 SGTC_2639 lactacystin 3.31 53.0 µM 1.08E-4 48 4.70E-4
16 SGTC_3006 9075424 3.22 71.4 µM 1.60E-4 36 6.47E-4
17 SGTC_431 k089-0097 3.18 107.0 µM 1.87E-4 iron homeostasis 80 7.33E-4
18 SGTC_2787 5284540 3.11 71.4 µM 2.54E-4 62 9.43E-4
19 SGTC_2126 5251174 3.06 33.9 µM 3.09E-4 90 0.00110
20 SGTC_832 4083-0019 3.05 164.0 µM 3.19E-4 translation 187 0.00113

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.438 8.51E-157 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.353 8.40E-99 YDL099W BUG1 hom Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
0.309 3.65E-75 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.287 9.07E-65 YGL040C HEM2 het Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus
0.283 5.95E-63 YGL222C EDC1 hom RNA-binding protein that activates mRNA decapping directly; binds to the mRNA substrate and enhances the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress
0.277 3.60E-60 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)
0.267 7.14E-56 YGL205W POX1 hom Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
0.244 1.41E-46 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.236 1.05E-43 YGR035C_p YGR035C_p hom Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.231 9.27E-42 YGL083W SCY1 hom Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase
0.224 3.26E-39 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.223 8.11E-39 YJR014W TMA22 hom Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress
0.215 2.62E-36 YJL149W DAS1 hom Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C
0.213 1.11E-35 YGL096W TOS8 hom Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication
0.208 5.33E-34 YJL087C TRL1 het tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes