YNR039C / ZRG17

Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency

Zygosity: Homozygous strain
fixedexpanded
Profile for YNR039C / ZRG17

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:6.31|P-value:1.48E-12 ID:SGTC_76|Compound:0433-0009|FD-Score:-2.96|P-value:6.05E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:2.81|P-value:8.94E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-2.91|P-value:7.16E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.08|P-value:3.73E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.33|P-value:8.39E-7 ID:SGTC_379|Compound:3970-0972|FD-Score:3.28|P-value:1.40E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-2.94|P-value:6.41E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.85|P-value:3.92E-8 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.10|P-value:3.41E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.28|P-value:1.37E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-2.95|P-value:6.15E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.01|P-value:4.83E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.00|P-value:5.67E-6 ID:SGTC_1115|Compound:galangin|FD-Score:3.47|P-value:5.89E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.27|P-value:1.67E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.73|P-value:1.84E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.28|P-value:1.40E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:2.80|P-value:9.51E-4 ID:SGTC_1705|Compound:st027868|FD-Score:2.91|P-value:6.12E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.49|P-value:5.39E-5 ID:SGTC_2103|Compound:5378138|FD-Score:3.36|P-value:9.65E-5 ID:SGTC_2143|Compound:5623677|FD-Score:2.98|P-value:4.74E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.33|P-value:1.34E-4 ID:SGTC_2625|Compound:euphol|FD-Score:4.26|P-value:1.21E-6 ID:SGTC_2795|Compound:7780010|FD-Score:-3.01|P-value:4.90E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.44|P-value:6.92E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.94|P-value:6.37E-6 ID:SGTC_2970|Compound:9090938|FD-Score:4.12|P-value:2.52E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-4.32|P-value:1.05E-6 ID:SGTC_3297|Compound:9117502|FD-Score:2.97|P-value:4.91E-4 ID:SGTC_3315|Compound:9136395|FD-Score:2.89|P-value:6.60E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.31|P-value:1.48E-12 ID:SGTC_76|Compound:0433-0009|FD-Score:-2.96|P-value:6.05E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:2.81|P-value:8.94E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-2.91|P-value:7.16E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.08|P-value:3.73E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:4.33|P-value:8.39E-7 ID:SGTC_379|Compound:3970-0972|FD-Score:3.28|P-value:1.40E-4 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:-2.94|P-value:6.41E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:4.85|P-value:3.92E-8 ID:SGTC_613|Compound:3914-0030|FD-Score:-3.10|P-value:3.41E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:3.28|P-value:1.37E-4 ID:SGTC_771|Compound:0250-0039|FD-Score:-2.95|P-value:6.15E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-3.01|P-value:4.83E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.00|P-value:5.67E-6 ID:SGTC_1115|Compound:galangin|FD-Score:3.47|P-value:5.89E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.27|P-value:1.67E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.73|P-value:1.84E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.28|P-value:1.40E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:2.80|P-value:9.51E-4 ID:SGTC_1705|Compound:st027868|FD-Score:2.91|P-value:6.12E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.49|P-value:5.39E-5 ID:SGTC_2103|Compound:5378138|FD-Score:3.36|P-value:9.65E-5 ID:SGTC_2143|Compound:5623677|FD-Score:2.98|P-value:4.74E-4 ID:SGTC_2484|Compound:5809818|FD-Score:-3.33|P-value:1.34E-4 ID:SGTC_2625|Compound:euphol|FD-Score:4.26|P-value:1.21E-6 ID:SGTC_2795|Compound:7780010|FD-Score:-3.01|P-value:4.90E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.44|P-value:6.92E-5 ID:SGTC_2808|Compound:7946468|FD-Score:3.94|P-value:6.37E-6 ID:SGTC_2970|Compound:9090938|FD-Score:4.12|P-value:2.52E-6 ID:SGTC_3206|Compound:9114350|FD-Score:-4.32|P-value:1.05E-6 ID:SGTC_3297|Compound:9117502|FD-Score:2.97|P-value:4.91E-4 ID:SGTC_3315|Compound:9136395|FD-Score:2.89|P-value:6.60E-4

Top fitness defect scores for YNR039C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 6.31 9.0 µM 1.48E-12 cell wall 192 1.36E-10
2 SGTC_612 0302-0167 4.85 22.4 µM 3.92E-8 copper-dependent oxidative stress 14 6.06E-7
3 SGTC_304 1310-0298 4.33 97.0 µM 8.39E-7 cell wall 52 7.62E-6
4 SGTC_2625 euphol 4.26 100.0 µM 1.21E-6 25 1.03E-5
5 SGTC_2970 9090938 4.12 41.9 µM 2.52E-6 RNA processing & uracil transport 33 1.89E-5
6 SGTC_2808 7946468 3.94 45.5 µM 6.37E-6 22 4.07E-5
7 SGTC_1251 0490-5699 3.73 265.0 µM 1.84E-5 40 9.76E-5
8 SGTC_1736 st036774 3.49 51.0 µM 5.39E-5 51 2.38E-4
9 SGTC_1115 galangin 3.47 695.7 nM 5.89E-5 RPP1 & pyrimidine depletion 26 2.56E-4
10 SGTC_2807 7945238 3.44 52.0 µM 6.92E-5 47 2.93E-4
11 SGTC_2103 5378138 3.36 10.0 µM 9.65E-5 37 3.86E-4
12 SGTC_763 3453-1109 3.28 128.0 µM 1.37E-4 39 5.17E-4
13 SGTC_1379 2144-0755 3.28 36.5 µM 1.40E-4 44 5.25E-4
14 SGTC_379 3970-0972 3.28 5.9 µM 1.40E-4 tubulin folding & SWR complex 63 5.25E-4
15 SGTC_2143 5623677 2.98 140.5 µM 4.74E-4 27 0.00144
16 SGTC_3297 9117502 2.97 71.4 µM 4.91E-4 37 0.00149
17 SGTC_1705 st027868 2.91 56.3 µM 6.12E-4 50 0.00179
18 SGTC_3315 9136395 2.89 68.5 µM 6.60E-4 50 0.00190
19 SGTC_122 0236-0016 2.81 402.4 µM 8.94E-4 RNA processing & uracil transport 117 0.00244
20 SGTC_1445 4239-0156 2.80 97.7 µM 9.51E-4 95 0.00257

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.277 7.05E-60 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.270 6.47E-57 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.265 5.17E-55 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.240 3.00E-45 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.240 3.63E-45 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.236 9.13E-44 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.236 1.42E-43 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.233 1.12E-42 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.230 1.24E-41 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.228 6.65E-41 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.227 1.88E-40 YPR023C EAF3 hom Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
0.213 1.20E-35 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.211 5.19E-35 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.209 1.64E-34 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.208 4.13E-34 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex